CCL13 chemokine (C-C motif) ligand 13 [Homo sapiens (human)]
| Gene Symbol | CCL13 |
| Entrez Gene ID | 6357 |
| Full Name | chemokine (C-C motif) ligand 13 |
| Synonyms | CKb10, MCP-4, MGC17134, NCC-1, NCC1, SCYA13, SCYL1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q11.2 |
| Summary | This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq]. |
| Disorder | MIM: 601391 |
| mRNA | NM_005408, 22538799 |
| Protein | NP_005399, 4885587 |
| Product | C-C motif chemokine 13 precursor |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | CCL13 | NP_005399.1 |
| Pan troglodytes (chimpanzee) | CCL13 | XP_001174525.1 |
| Canis lupus familiaris (dog) | CCL13 | NP_001003966.1 |
| Mus musculus (house mouse) | Ccl2 | NP_035463.1 |
| Rattus norvegicus (Norway rat) | Ccl2 | NP_113718.1 |
| ID | Name | Evidence |
| GO:0006874 | cellular calcium ion homeostasis | TAS |
| GO:0006935 | chemotaxis | IEA |
| GO:0006954 | inflammatory response | IEA |
| GO:0006955 | immune response | IEA |
| GO:0007165 | signal transduction | NAS |
| GO:0007267 | cell-cell signaling | TAS |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005615 | extracellular space | IEA |
Function
| ID | Name | Evidence |
| GO:0004871 | signal transducer activity | NAS |
| GO:0005102 | receptor binding | TAS |
| GO:0008009 | chemokine activity | IEA |
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