CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) [Homo sapiens (human)]
| Gene Symbol | CCL18 |
| Entrez Gene ID | 6362 |
| Full Name | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| Synonyms | AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q11.2 |
| Summary | This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq]. |
| Disorder | MIM: 603757 |
| mRNA | NM_002988, 22547150 |
| Protein | NP_002979, 4506831 |
| Product | C-C motif chemokine 18 precursor |
| RefSeq Status | VALIDATED |
| Homo sapiens (human) | CCL18 | NP_002979.1 |
| Pan troglodytes (chimpanzee) | CCL18 | XP_523615.1 |
| ID | Name | Evidence |
| GO:0006935 | chemotaxis | IEA |
| GO:0006954 | inflammatory response | IEA |
| GO:0006955 | immune response | IEA |
| GO:0007154 | cell communication | TAS |
| GO:0007165 | signal transduction | TAS |
| GO:0007267 | cell-cell signaling | TAS |
| GO:0009607 | response to biotic stimulus | TAS |
Component
| ID | Name | Evidence |
| GO:0005576 | extracellular region | IEA |
| GO:0005615 | extracellular space | IEA |
Function
| ID | Name | Evidence |
| GO:0008009 | chemokine activity | IEA |
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