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SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_004168 Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), nuclear gene encoding mitochondrial protein, mRNA. ORF Sequence $578.55
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Gene Symbol SDHA
Entrez Gene ID 6389
Full Name succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms CMD1GG, FP, SDH1, SDH2, SDHF
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5p15

Summary This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600857

Leigh syndrome, 256000 (3); Mitochondrial respiratory chain complex

mRNA Protein Product Sequence Price Select
NM_004168, 156416002 NP_004159, 156416003 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Full Length $697.45
ORF Sequence $578.55
KEGG
hsa_M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa00020Citrate cycle (TCA cycle)
hsa_M00148Succinate dehydrogenase (ubiquinone)
hsa05016Huntington's disease
hsa05012Parkinson's disease
hsa05010Alzheimer's disease
hsa00190Oxidative phosphorylation
WikiPathways
WP78TCA Cycle
WP111Electron Transport Chain
BIOCYC
HUMAN_PWY-5690TCA cycle II (eukaryotic)
Reactome
REACT_1785Citric acid cycle (TCA cycle)
REACT_6305Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
REACT_22393Respiratory electron transport
REACT_111217Metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
Homo sapiens (human)SDHANP_004159.2
Pan troglodytes (chimpanzee)LOC100608629XP_003310656.1
Macaca mulatta (Rhesus monkey)LOC708018XP_001094170.2
Canis lupus familiaris (dog)SDHAXP_535807.3
Bos taurus (cattle)SDHANP_776603.1
Mus musculus (house mouse)SdhaNP_075770.1
Rattus norvegicus (Norway rat)SdhaNP_569112.1
Gallus gallus (chicken)SDHAXP_419054.2
Danio rerio (zebrafish)sdhaNP_957204.1
Drosophila melanogaster (fruit fly)SdhANP_725882.1
Caenorhabditis eleganssdha-1NP_509446.1
Caenorhabditis eleganssdha-2NP_492798.1
Arabidopsis thaliana (thale cress)SDH1-1NP_201477.1
GeneCards SDHA
UniProt P31040
MIM 600857
Ensembl ENSG00000073578
HGNC 10680
HPRD 02914

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
flavoprotein subunit of complex II
succinate dehydrogenase complex flavoprotein subunit
NP_004159.2

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