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SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28692 NM_004168 Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu28693 NM_001294332 Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu39347 XM_005248329 PREDICTED: Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu39348 XM_005248331 PREDICTED: Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu28692C NM_004168 Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu28693C NM_001294332 Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu39347C XM_005248329 PREDICTED: Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu39348C XM_005248331 PREDICTED: Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol SDHA
Entrez Gene ID 6389
Full Name succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms CMD1GG, FP, PGL5, SDH1, SDH2, SDHF
General protein information
Preferred Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
flavoprotein subunit of complex II
succinate dehydrogenase complex flavoprotein subunit
NP_004159.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5p15

Summary This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014].
Disorder

MIM: 600857

Leigh syndrome, 256000 (3); Mitochondrial respiratory chain complex

mRNA Protein Product Sequence Price Select
NM_001294332, 661567359 NP_001281261, 661567360 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 2 ORF Sequence $700.00
NM_004168, 661567358 NP_004159, 156416003 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform 1 ORF Sequence $700.00
XM_005248329, 530378870 XP_005248386, 530378871 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 ORF Sequence $700.00
XM_005248331, 530378874 XP_005248388, 530378875 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X3 ORF Sequence $700.00
KEGG
hsa00020Citrate cycle (TCA cycle)
hsa00190Oxidative phosphorylation
hsa05016Huntington's disease
hsa05012Parkinson's disease
hsa05010Alzheimer's disease
hsa_M00148Succinate dehydrogenase (ubiquinone)
hsa_M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa01200Carbon metabolism
hsa_M00009Citrate cycle (TCA cycle, Krebs cycle)
hsa04932Non-alcoholic fatty liver disease (NAFLD)
WikiPathways
WP78TCA Cycle
WP111Electron Transport Chain
BIOCYC
HUMAN_PWY-5690TCA cycle II (eukaryotic)
META_PWY66-398TCA cycle VIII (metazoan)
Reactome
REACT_6305Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
REACT_1785Citric acid cycle (TCA cycle)
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_22393Respiratory electron transport
REACT_111217Metabolism
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
Homo sapiens (human)SDHANP_004159.2
Pan troglodytes (chimpanzee)SDHAXP_003310656.1
Macaca mulatta (Rhesus monkey)LOC708018XP_001094170.2
Canis lupus familiaris (dog)SDHAXP_535807.4
Bos taurus (cattle)SDHANP_776603.1
Mus musculus (house mouse)SdhaNP_075770.1
Rattus norvegicus (Norway rat)SdhaNP_569112.1
Gallus gallus (chicken)SDHANP_001264327.1
Danio rerio (zebrafish)sdhaNP_957204.1
Drosophila melanogaster (fruit fly)SdhANP_725882.1
Caenorhabditis eleganssdha-1NP_509446.1
Caenorhabditis eleganssdha-2NP_492798.1
Arabidopsis thaliana (thale cress)SDH1-1NP_201477.1
Xenopus (Silurana) tropicalis (western clawed frog)sdhaNP_001015989.1
Process
IDNameEvidence
GO:0006099tricarboxylic acid cycleIEA
GO:0006099tricarboxylic acid cycleTAS
GO:0006105succinate metabolic processIDA
GO:0007399nervous system developmentIMP
GO:0022904respiratory electron transport chainIDA
GO:0022904respiratory electron transport chainTAS
GO:0044237cellular metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIDA
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005743mitochondrial inner membraneISS
GO:0005743mitochondrial inner membraneTAS
GO:0005749mitochondrial respiratory chain complex IIISS
GO:0005749mitochondrial respiratory chain complex IITAS
Function
IDNameEvidence
GO:0000104succinate dehydrogenase activityIMP
GO:0005515protein bindingIPI
GO:0008177succinate dehydrogenase (ubiquinone) activityIEA
GO:0050660flavin adenine dinucleotide bindingIEA
GeneCards SDHA
UniProt D6RFM5, P31040
Vega OTTHUMG00000090275
MIM 600857
Ensembl ENSG00000073578
HGNC 10680
HPRD 02914

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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