SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [Homo sapiens (human)]
| Gene Symbol | SDHB |
| Entrez Gene ID | 6390 |
| Full Name | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| Synonyms | FLJ92337, IP, PGL4, SDH, SDH1, SDH2, SDHIP |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36.1-p35 |
| Summary | Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]. |
| Disorder | MIM: 185470 Paraganglioma, familial chromaffin, 4, 115310 (3); Pheochromocytoma, |
| mRNA | NM_003000, 115387093 |
| Protein | NP_002991, 115387094 |
| Product | succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor |
| RefSeq Status | REVIEWED |
| hsa05010 | Alzheimer's disease |
| hsa00190 | Oxidative phosphorylation |
| hsa00020 | Citrate cycle (TCA cycle) |
| hsa01100 | Metabolic pathways |
| hsa05016 | Huntington's disease |
| hsa05012 | Parkinson's disease |
WikiPathways
| WP78 | TCA Cycle |
| WP111 | Electron Transport Chain |
BIOCYC
| META_PWY-5690 | TCA cycle variation III (eukaryotic) |
Reactome
| REACT_1046 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| REACT_6305 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| REACT_22393 | Respiratory electron transport |
| REACT_1785 | Citric acid cycle (TCA cycle) |
| Homo sapiens (human) | SDHB | NP_002991.2 |
| Pan troglodytes (chimpanzee) | SDHB | XP_001155328.1 |
| Canis lupus familiaris (dog) | SDHB | XP_535392.1 |
| Canis lupus familiaris (dog) | SDHB | XP_850262.1 |
| Bos taurus (cattle) | SDHB | NP_001035573.1 |
| Mus musculus (house mouse) | Sdhb | NP_075863.2 |
| Rattus norvegicus (Norway rat) | Sdhb | XP_216558.3 |
| Gallus gallus (chicken) | SDHB | XP_001232709.1 |
| Danio rerio (zebrafish) | sdhb | NP_001092210.1 |
| Drosophila melanogaster (fruit fly) | SdhB | NP_477101.1 |
| Caenorhabditis elegans | sdhb-1 | NP_495992.1 |
| Arabidopsis thaliana (thale cress) | SDH2-3 | NP_680465.2 |
| ID | Name | Evidence |
| GO:0006099 | tricarboxylic acid cycle | TAS |
| GO:0006105 | succinate metabolic process | IEA |
| GO:0006810 | transport | IEA |
| GO:0009060 | aerobic respiration | TAS |
| GO:0022904 | respiratory electron transport chain | TAS |
Component
| ID | Name | Evidence |
| GO:0005739 | mitochondrion | IDA |
| GO:0005743 | mitochondrial inner membrane | EXP |
| GO:0005743 | mitochondrial inner membrane | ISS |
| GO:0005749 | mitochondrial respiratory chain complex II | ISS |
| GO:0016020 | membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
| GO:0008177 | succinate dehydrogenase (ubiquinone) activity | IEA |
| GO:0009055 | electron carrier activity | IEA |
| GO:0016491 | oxidoreductase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
| GO:0048039 | ubiquinone binding | ISS |
| GO:0051537 | 2 iron, 2 sulfur cluster binding | ISS |
| GO:0051538 | 3 iron, 4 sulfur cluster binding | ISS |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | ISS |
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