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SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003000 Homo sapiens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein, mRNA. GenEZ ORF Cloning On-demand $449.00 14

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Gene Symbol SDHB
Entrez Gene ID 6390
Full Name succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Synonyms FLJ92337, IP, PGL4, SDH, SDH1, SDH2, SDHIP
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.1-p35

Summary Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 185470

Paraganglioma, familial chromaffin, 4, 115310 (3); Pheochromocytoma,

mRNA Protein Product Sequence Price Select
NM_003000, 115387093 NP_002991, 115387094 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor ORF Sequence $300.00
KEGG
hsa05012Parkinson's disease
hsa_M00148Succinate dehydrogenase (ubiquinone)
hsa05010Alzheimer's disease
hsa_M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
hsa00190Oxidative phosphorylation
hsa00020Citrate cycle (TCA cycle)
hsa05016Huntington's disease
WikiPathways
WP78TCA Cycle
WP111Electron Transport Chain
BIOCYC
HUMAN_PWY-5690TCA cycle II (eukaryotic)
Reactome
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
REACT_1785Citric acid cycle (TCA cycle)
REACT_22393Respiratory electron transport
REACT_111217Metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_6305Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Homo sapiens (human)SDHBNP_002991.2
Pan troglodytes (chimpanzee)SDHBXP_001155516.1
Macaca mulatta (Rhesus monkey)SDHBXP_001088349.1
Canis lupus familiaris (dog)SDHBNP_001239146.1
Bos taurus (cattle)SDHBNP_001035573.1
Mus musculus (house mouse)SdhbNP_075863.2
Rattus norvegicus (Norway rat)SdhbNP_001094009.1
Gallus gallus (chicken)LOC100859720XP_003642552.1
Gallus gallus (chicken)SDHBNP_001074344.1
Danio rerio (zebrafish)sdhbNP_001092210.1
Drosophila melanogaster (fruit fly)SdhBNP_477101.1
Caenorhabditis eleganssdhb-1NP_495992.1
Arabidopsis thaliana (thale cress)SDH2-3NP_680465.2
GeneCards SDHB
UniProt P21912
MIM 185470
Ensembl ENSG00000117118
HGNC 10681
HPRD 01707

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
iron-sulfur subunit of complex II
NP_002991.2

Interactant



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