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SDHD succinate dehydrogenase complex, subunit D, integral membrane protein [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001276503 Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $299.00 14
NM_001276504 Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD), nuclear gene encoding mitochondrial protein, transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $299.00 14
NM_001276506 Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD), nuclear gene encoding mitochondrial protein, transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $299.00 14
NM_003002 Homo sapiens succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

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Gene Symbol SDHD
Entrez Gene ID 6392
Full Name succinate dehydrogenase complex, subunit D, integral membrane protein
Synonyms CBT1, PGL, PGL1, SDH4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23

Summary This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Disorder

MIM: 602690

Paragangliomas, familial nonchromaffin, 1, with or without deafness,

mRNA Protein Product Sequence Price Select
NM_001276503, 452405464 NP_001263432, 452405465 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform b precursor ORF Sequence $150.00
NM_001276504, 452405677 NP_001263433, 452405678 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform c precursor ORF Sequence $150.00
NM_001276506, 452406067 NP_001263435, 452406068 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform d precursor ORF Sequence $150.00
NM_003002, 452405284 NP_002993, 4506865 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform a precursor ORF Sequence $159.00
KEGG
hsa05010Alzheimer's disease
hsa00020Citrate cycle (TCA cycle)
hsa_M00148Succinate dehydrogenase (ubiquinone)
hsa05016Huntington's disease
hsa05012Parkinson's disease
hsa00190Oxidative phosphorylation
hsa_M00011Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
WikiPathways
WP78TCA Cycle
WP111Electron Transport Chain
BIOCYC
HUMAN_PWY-5690TCA cycle II (eukaryotic)
Reactome
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_111217Metabolism
REACT_1785Citric acid cycle (TCA cycle)
REACT_6305Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
REACT_22393Respiratory electron transport
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
Homo sapiens (human)SDHDNP_002993.1
Pan troglodytes (chimpanzee)SDHDXP_508756.1
Macaca mulatta (Rhesus monkey)SDHDXP_001093794.1
Macaca mulatta (Rhesus monkey)SDHDXP_001107882.1
Canis lupus familiaris (dog)SDHDXP_536573.3
Bos taurus (cattle)SDHDNP_776604.1
Mus musculus (house mouse)SdhdNP_080124.1
Rattus norvegicus (Norway rat)SdhdNP_942083.1
Gallus gallus (chicken)SDHDNP_001006321.1
Danio rerio (zebrafish)sdhdaNP_001002489.1
Danio rerio (zebrafish)sdhdbNP_001004004.1
Drosophila melanogaster (fruit fly)CG10219NP_651181.1
GeneCards SDHD
UniProt O14521, E9PQI9, E9PIC0, E9PIG3
MIM 602690
Ensembl ENSG00000204370
HGNC 10683
HPRD 04069

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Names
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
succinate-ubiquinone reductase membrane anchor subunit
succinate-ubiquinone oxidoreductase cytochrome b small subunit

Interactant



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