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NOD2 nucleotide-binding oligomerization domain containing 2 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_022162 Homo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), mRNA. ORF Sequence $1093.05
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Gene Symbol NOD2
Entrez Gene ID 64127
Full Name nucleotide-binding oligomerization domain containing 2
Synonyms ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q21

Summary This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605956

{Inflammatory bowel disease 1}, 266600 (3); Blau syndrome, 186580

mRNA Protein Product Sequence Price Select
NM_022162, 11545911 NP_071445, 11545912 nucleotide-binding oligomerization domain-containing protein 2 Full Length $1569.75
ORF Sequence $1093.05
KEGG
hsa05131Shigellosis
hsa05152Tuberculosis
hsa04621NOD-like receptor signaling pathway
WikiPathways
WP1433NOD pathway
Pathway Interaction Database
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
Reactome
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6900Immune System
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_22232Signaling by Interleukins
REACT_21308MAP kinase activation in TLR cascade
REACT_6966Toll Receptor Cascades
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_25281NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_75776NOD1/2 Signaling Pathway
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_75790Cytokine Signaling in Immune system
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_6802Innate Immune System
REACT_6809MyD88-independent cascade
REACT_6890Activated TLR4 signalling
REACT_22442Interleukin-1 signaling
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Homo sapiens (human)NOD2NP_071445.1
Pan troglodytes (chimpanzee)NOD2NP_001098710.1
Macaca mulatta (Rhesus monkey)NOD2XP_001084287.1
Canis lupus familiaris (dog)NOD2XP_544412.3
Bos taurus (cattle)NOD2NP_001002889.1
Mus musculus (house mouse)Nod2NP_665856.2
Rattus norvegicus (Norway rat)Nod2NP_001099642.1
Danio rerio (zebrafish)nod2XP_697924.3
GeneCards NOD2
UniProt Q9HC29
MIM 605956
Ensembl ENSG00000167207
HGNC 5331
HPRD 05810

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant

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