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NOD2 nucleotide-binding oligomerization domain containing 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001293557 Homo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_022162 Homo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005256084 PREDICTED: Homo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_006721242 PREDICTED: Homo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006721243 PREDICTED: Homo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol NOD2
Entrez Gene ID 64127
Full Name nucleotide-binding oligomerization domain containing 2
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014].

MIM: 605956

{Inflammatory bowel disease 1}, 266600 (3); Blau syndrome, 186580

mRNA Protein Product Sequence Price Select
NM_001293557, 649572335 NP_001280486, 649572336 nucleotide-binding oligomerization domain-containing protein 2 isoform 2 ORF Sequence $1500.00
NM_022162, 649572334 NP_071445, 11545912 nucleotide-binding oligomerization domain-containing protein 2 isoform 1 ORF Sequence $1500.00
XM_005256084, 530424183 XP_005256141, 530424184 nucleotide-binding oligomerization domain-containing protein 2 isoform X1 ORF Sequence $1500.00
XM_006721242, 578829111 XP_006721305, 578829112 nucleotide-binding oligomerization domain-containing protein 2 isoform X2 ORF Sequence $750.00
XM_006721243, 578829115 XP_006721306, 578829116 nucleotide-binding oligomerization domain-containing protein 2 isoform X3 ORF Sequence $750.00
hsa04621NOD-like receptor signaling pathway
hsa05321Inflammatory bowel disease (IBD)
hsa04668TNF signaling pathway
WP1433NOD pathway
Pathway Interaction Database
nfkappabcanonicalpathwayCanonical NF-kappaB pathway
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_6809MyD88-independent cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_6966Toll-Like Receptors Cascades
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_22232Signaling by Interleukins
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_22442Interleukin-1 signaling
REACT_21308MAP kinase activation in TLR cascade
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_75776NOD1/2 Signaling Pathway
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75790Cytokine Signaling in Immune system
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
Homo sapiens (human)NOD2NP_071445.1
Pan troglodytes (chimpanzee)NOD2NP_001098710.1
Macaca mulatta (Rhesus monkey)NOD2XP_001084287.1
Canis lupus familiaris (dog)NOD2XP_005617627.1
Bos taurus (cattle)NOD2NP_001002889.1
Mus musculus (house mouse)Nod2NP_665856.2
Rattus norvegicus (Norway rat)Nod2NP_001099642.1
Danio rerio (zebrafish)nod2XP_697924.3
GO:0000187activation of MAPK activityTAS
GO:0002224toll-like receptor signaling pathwayTAS
GO:0002227innate immune response in mucosaIEA
GO:0002282microglial cell activation involved in immune responseIEA
GO:0002367cytokine production involved in immune responseIMP
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune responseIEA
GO:0002606positive regulation of dendritic cell antigen processing and presentationISS
GO:0002710negative regulation of T cell mediated immunityIEA
GO:0002732positive regulation of dendritic cell cytokine productionIEA
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTAS
GO:0002756MyD88-independent toll-like receptor signaling pathwayTAS
GO:0002830positive regulation of type 2 immune responseIMP
GO:0002862negative regulation of inflammatory response to antigenic stimulusIEA
GO:0002925positive regulation of humoral immune response mediated by circulating immunoglobulinIEA
GO:0006952defense responseTAS
GO:0006965positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteriaIEA
GO:0007254JNK cascadeTAS
GO:0007584response to nutrientIEA
GO:0009595detection of biotic stimulusTAS
GO:0016045detection of bacteriumIDA
GO:0030277maintenance of gastrointestinal epitheliumIMP
GO:0032088negative regulation of NF-kappaB transcription factor activityIEA
GO:0032495response to muramyl dipeptideIDA
GO:0032496response to lipopolysaccharideIEA
GO:0032498detection of muramyl dipeptideIDA
GO:0032689negative regulation of interferon-gamma productionIEA
GO:0032695negative regulation of interleukin-12 productionIEA
GO:0032701negative regulation of interleukin-18 productionIEA
GO:0032703negative regulation of interleukin-2 productionIEA
GO:0032720negative regulation of tumor necrosis factor productionIEA
GO:0032731positive regulation of interleukin-1 beta productionIMP
GO:0032733positive regulation of interleukin-10 productionISS
GO:0032735positive regulation of interleukin-12 productionIEA
GO:0032740positive regulation of interleukin-17 productionIMP
GO:0032755positive regulation of interleukin-6 productionIDA
GO:0032760positive regulation of tumor necrosis factor productionIDA
GO:0032760positive regulation of tumor necrosis factor productionIMP
GO:0032874positive regulation of stress-activated MAPK cascadeIDA
GO:0034134toll-like receptor 2 signaling pathwayTAS
GO:0034136negative regulation of toll-like receptor 2 signaling pathwayIEA
GO:0034138toll-like receptor 3 signaling pathwayTAS
GO:0034142toll-like receptor 4 signaling pathwayTAS
GO:0034146toll-like receptor 5 signaling pathwayTAS
GO:0034162toll-like receptor 9 signaling pathwayTAS
GO:0034166toll-like receptor 10 signaling pathwayTAS
GO:0035419activation of MAPK activity involved in innate immune responseISS
GO:0035556intracellular signal transductionIDA
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTAS
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTAS
GO:0038123toll-like receptor TLR1:TLR2 signaling pathwayTAS
GO:0038124toll-like receptor TLR6:TLR2 signaling pathwayTAS
GO:0042742defense response to bacteriumIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDA
GO:0043330response to exogenous dsRNAIEA
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityISS
GO:0044130negative regulation of growth of symbiont in hostIEA
GO:0045087innate immune responseIDA
GO:0045087innate immune responseNAS
GO:0045087innate immune responseTAS
GO:0045747positive regulation of Notch signaling pathwayISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046330positive regulation of JNK cascadeIDA
GO:0046645positive regulation of gamma-delta T cell activationISS
GO:0050679positive regulation of epithelial cell proliferationISS
GO:0050718positive regulation of interleukin-1 beta secretionIDA
GO:0050727regulation of inflammatory responseIC
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA
GO:0050766positive regulation of phagocytosisIEA
GO:0050830defense response to Gram-positive bacteriumIEA
GO:0050871positive regulation of B cell activationIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityTAS
GO:0051259protein oligomerizationTAS
GO:0051353positive regulation of oxidoreductase activityISS
GO:0051403stress-activated MAPK cascadeTAS
GO:0051770positive regulation of nitric-oxide synthase biosynthetic processISS
GO:0052033pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEA
GO:0060585positive regulation of prostaglandin-endoperoxide synthase activityISS
GO:0070374positive regulation of ERK1 and ERK2 cascadeISS
GO:0070423nucleotide-binding oligomerization domain containing signaling pathwayTAS
GO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathwayIDA
GO:0071224cellular response to peptidoglycanIEA
GO:0071225cellular response to muramyl dipeptideIDA
GO:0071608macrophage inflammatory protein-1 alpha productionIEA
GO:0090022regulation of neutrophil chemotaxisIEA
GO:2000110negative regulation of macrophage apoptotic processISS
GO:2000363positive regulation of prostaglandin-E synthase activityISS
GO:0005886plasma membraneIDA
GO:0008180COP9 signalosomeIDA
GO:0009986cell surfaceIDA
GO:0043234protein complexIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019899enzyme bindingIPI
GO:0019901protein kinase bindingIPI
GO:0032500muramyl dipeptide bindingIDA
GO:0042834peptidoglycan bindingIDA
GO:0050700CARD domain bindingIPI
GeneCards NOD2
UniProt Q9HC29
Vega OTTHUMG00000133171
MIM 605956
Ensembl ENSG00000167207
HGNC 5331
HPRD 05810

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the NOD2 gene?

The NOD2 gene provides instructions for making a protein that plays an important role in immune system function. The NOD2 protein is active in some types of immune system cells (including monocytes, macrophages, and dendritic cells), which help protect the body against foreign invaders such as viruses and bacteria. The protein is also active in several types of epithelial cells, including Paneth cells, which are found in the lining of the intestine. These cells help defend the intestinal wall against bacterial infection.

The NOD2 protein has several critical functions in defending the body against foreign invaders. The protein is involved in recognizing certain bacteria and stimulating the immune system to respond properly. When triggered by specific substances produced by bacteria, the NOD2 protein turns on (activates) a protein complex called nuclear factor-kappa-B. This protein complex regulates the activity of multiple genes, including genes that control immune responses and inflammatory reactions. An inflammatory reaction occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair.

The NOD2 protein also appears to play a role in a process called autophagy, which cells use to surround and destroy bacteria and viruses. In addition to protecting cells from infection, autophagy is used to recycle worn-out cell parts and break down certain proteins when they are no longer needed. This process is also involved in the self-destruction of cells (apoptosis).


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