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ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_022436 Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
XM_005264480 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005264481 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006712073 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006712074 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Related Services

Gene Symbol ABCG5
Entrez Gene ID 64240
Full Name ATP-binding cassette, sub-family G (WHITE), member 5
Synonyms STSL
General protein information
Preferred Names
ATP-binding cassette sub-family G member 5
Names
ATP-binding cassette sub-family G member 5
sterolin 1
sterolin-1
ATP-binding cassette, subfamily G, member 5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p21

Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605459

Sitosterolemia, 210250 (3)

mRNA Protein Product Sequence Price Select
NM_022436, 14141174 NP_071881, 11967969 ATP-binding cassette sub-family G member 5 ORF Sequence $490.00
XM_005264480, 530367935 XP_005264537, 530367936 ATP-binding cassette sub-family G member 5 isoform X1 ORF Sequence $550.00
XM_005264481, 530367937 XP_005264538, 530367938 ATP-binding cassette sub-family G member 5 isoform X2 ORF Sequence $550.00
XM_006712073, 578803087 XP_006712136, 578803088 ATP-binding cassette sub-family G member 5 isoform X3 ORF Sequence $700.00
XM_006712074, 578803089 XP_006712137, 578803090 ATP-binding cassette sub-family G member 5 isoform X4 ORF Sequence $400.00
KEGG
hsa02010ABC transporters
hsa04975Fat digestion and absorption
hsa04976Bile secretion
WikiPathways
WP716Vitamin A and carotenoid metabolism
WP430Statin Pathway
WP299Nuclear receptors in lipid metabolism and toxicity
Reactome
REACT_602Lipid digestion, mobilization, and transport
REACT_13781Trafficking of dietary sterols
REACT_15480ABC-family proteins mediated transport
REACT_15518Transmembrane transport of small molecules
REACT_22258Metabolism of lipids and lipoproteins
REACT_111158ABCA transporters in lipid homeostasis
REACT_111217Metabolism
Homo sapiens (human)ABCG5NP_071881.1
Pan troglodytes (chimpanzee)ABCG5XP_003309098.1
Macaca mulatta (Rhesus monkey)ABCG5XP_001111277.1
Canis lupus familiaris (dog)ABCG5XP_538475.1
Bos taurus (cattle)ABCG5NP_001019718.1
Mus musculus (house mouse)Abcg5NP_114090.1
Rattus norvegicus (Norway rat)Abcg5NP_446206.2
Gallus gallus (chicken)ABCG5XP_419457.3
Danio rerio (zebrafish)abcg5NP_001122162.1
Drosophila melanogaster (fruit fly)CG11069NP_651307.2
Xenopus (Silurana) tropicalis (western clawed frog)abcg5NP_001120613.1
Process
IDNameEvidence
GO:0006200ATP catabolic processIDA
GO:0006200ATP catabolic processIEA
GO:0007584response to nutrientIEA
GO:0007588excretionIGI
GO:0010212response to ionizing radiationIEA
GO:0010949negative regulation of intestinal phytosterol absorptionIMP
GO:0015918sterol transportTAS
GO:0030299intestinal cholesterol absorptionIC
GO:0033344cholesterol effluxIGI
GO:0042493response to drugIEA
GO:0042632cholesterol homeostasisIMP
GO:0044281small molecule metabolic processTAS
GO:0045796negative regulation of intestinal cholesterol absorptionIMP
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIEA
GO:0016324apical plasma membraneIMP
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0016887ATPase activityIDA
GO:0017127cholesterol transporter activityIGI
GO:0046982protein heterodimerization activityIPI
GeneCards ABCG5
UniProt Q9H222
Vega OTTHUMG00000128758
MIM 605459
Ensembl ENSG00000138075
HGNC 13886
HPRD 05678

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the ABCG5 gene?

The ABCG5 gene provides instructions for making sterolin-1, which makes up half of a protein called sterolin. The other half of the sterolin protein, sterolin-2, is produced from a gene called ABCG8. Sterolin is involved in eliminating plant sterols, which are fatty components of plant-based foods that cannot be used by human cells.

Sterolin is a transporter protein, which is a type of protein that moves substances across cell membranes. It is found mostly in cells of the intestines and liver and transports plant sterols. After plant sterols are absorbed from food into intestinal cells, the sterolin transporters in these cells pump them back into the intestinal tract. Sterolin transporters in liver cells pump the plant sterols into a fluid called bile that is released into the intestine. From the intestine, the plant sterols are eliminated with the feces. This process removes most of the dietary plant sterols, and allows only about 5 percent of these substances to get into the bloodstream. Sterolin also helps regulate levels of cholesterol, another fatty substance found in animal products, in a similar fashion; normally about 50 percent of cholesterol in the diet is absorbed by the body.

Interactant

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