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ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24808 NM_022436 Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu35542 XM_006712073 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu35543 XM_005264480 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu35544 XM_005264481 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu35545 XM_006712074 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu24808C NM_022436 Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), mRNA. Customized vector In-stock 5-7 $149.00
OHu35542C XM_006712073 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X3, mRNA. Customized vector On-demand 7-9 $269.00
OHu35543C XM_005264480 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu35544C XM_005264481 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00
OHu35545C XM_006712074 PREDICTED: Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5), transcript variant X4, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol ABCG5
Entrez Gene ID 64240
Full Name ATP-binding cassette, sub-family G (WHITE), member 5
Synonyms STSL
General protein information
Preferred Names
ATP-binding cassette sub-family G member 5
Names
ATP-binding cassette sub-family G member 5
sterolin 1
sterolin-1
ATP-binding cassette, subfamily G, member 5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p21

Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008].
Disorder

MIM: 605459

Sitosterolemia, 210250 (3)

mRNA Protein Product Sequence Price Select
NM_022436, 14141174 NP_071881, 11967969 ATP-binding cassette sub-family G member 5 ORF Sequence $490.00
XM_005264480, 530367935 XP_005264537, 530367936 ATP-binding cassette sub-family G member 5 isoform X1 ORF Sequence $550.00
XM_005264481, 530367937 XP_005264538, 530367938 ATP-binding cassette sub-family G member 5 isoform X2 ORF Sequence $550.00
XM_006712073, 578803087 XP_006712136, 578803088 ATP-binding cassette sub-family G member 5 isoform X3 ORF Sequence $700.00
XM_006712074, 578803089 XP_006712137, 578803090 ATP-binding cassette sub-family G member 5 isoform X4 ORF Sequence $400.00
KEGG
hsa02010ABC transporters
hsa04975Fat digestion and absorption
hsa04976Bile secretion
WikiPathways
WP716Vitamin A and carotenoid metabolism
WP430Statin Pathway
WP299Nuclear receptors in lipid metabolism and toxicity
Reactome
REACT_602Lipid digestion, mobilization, and transport
REACT_13781Trafficking of dietary sterols
REACT_15480ABC-family proteins mediated transport
REACT_15518Transmembrane transport of small molecules
REACT_22258Metabolism of lipids and lipoproteins
REACT_111158ABCA transporters in lipid homeostasis
REACT_111217Metabolism
Homo sapiens (human)ABCG5NP_071881.1
Pan troglodytes (chimpanzee)ABCG5XP_003309098.1
Macaca mulatta (Rhesus monkey)ABCG5XP_001111277.1
Canis lupus familiaris (dog)ABCG5XP_538475.1
Bos taurus (cattle)ABCG5NP_001019718.1
Mus musculus (house mouse)Abcg5NP_114090.1
Rattus norvegicus (Norway rat)Abcg5NP_446206.2
Gallus gallus (chicken)ABCG5XP_419457.3
Danio rerio (zebrafish)abcg5NP_001122162.1
Drosophila melanogaster (fruit fly)CG11069NP_651307.2
Xenopus (Silurana) tropicalis (western clawed frog)abcg5NP_001120613.1
Process
IDNameEvidence
GO:0006200ATP catabolic processIDA
GO:0006200ATP catabolic processIEA
GO:0007584response to nutrientIEA
GO:0007588excretionIGI
GO:0010212response to ionizing radiationIEA
GO:0010949negative regulation of intestinal phytosterol absorptionIMP
GO:0015918sterol transportTAS
GO:0030299intestinal cholesterol absorptionIC
GO:0033344cholesterol effluxIGI
GO:0042493response to drugIEA
GO:0042632cholesterol homeostasisIMP
GO:0044281small molecule metabolic processTAS
GO:0045796negative regulation of intestinal cholesterol absorptionIMP
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIEA
GO:0016324apical plasma membraneIMP
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0016887ATPase activityIDA
GO:0017127cholesterol transporter activityIGI
GO:0046982protein heterodimerization activityIPI
GeneCards ABCG5
UniProt Q9H222
Vega OTTHUMG00000128758
MIM 605459
Ensembl ENSG00000138075
HGNC 13886
HPRD 05678

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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