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SFTPB surfactant protein B [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_198843 Homo sapiens surfactant protein B (SFTPB), transcript variant 2, mRNA. Full Length $827.66
ORF Sequence $342.78
NM_000542 Homo sapiens surfactant protein B (SFTPB), transcript variant 1, mRNA. Full Length $1288.35
ORF Sequence $342.78


Gene Symbol SFTPB
Entrez Gene ID 6439
Full Name surfactant protein B
Synonyms PSP-B, SFTB3, SFTP3, SMDP1, SP-B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p12-p11.2
Summary This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
Disorder

MIM: 178640

Surfactant metabolism dysfunction, pulmonary, 1, 265120 (3)
mRNA NM_198843, 288856296
Protein NP_942140, 288856297
Product pulmonary surfactant-associated protein B precursor
RefSeq Status REVIEWED
mRNA NM_000542, 288856298
Protein NP_000533, 288856299
Product pulmonary surfactant-associated protein B precursor
RefSeq Status REVIEWED
Homo sapiens (human)SFTPBNP_942140.2
Pan troglodytes (chimpanzee)SFTPBXP_001168379.1
Bos taurus (cattle)SFTPBNP_001068779.1
Mus musculus (house mouse)SftpbNP_680088.1
Rattus norvegicus (Norway rat)SftpbNP_620197.1
Process
IDNameEvidence
GO:0001666response to hypoxiaIEA
GO:0006629lipid metabolic processIEA
GO:0006665sphingolipid metabolic processIEA
GO:0007585respiratory gaseous exchangeIEA
GO:0007623circadian rhythmIEA
GO:0009749response to glucose stimulusIEA
GO:0009887organ morphogenesisTAS
GO:0032496response to lipopolysaccharideIEA
GO:0033189response to vitamin AIEA
GO:0051384response to glucocorticoid stimulusIEA
GO:0055093response to hyperoxiaIEA
GO:0070741response to interleukin-6IEA
GO:0070849response to epidermal growth factor stimulusIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0071732cellular response to nitric oxideIEA
Component
IDNameEvidence
GO:0005576extracellular regionIEA
GO:0005615extracellular spaceIEA
GO:0005737cytoplasmIEA
GO:0005764lysosomeIEA
GO:0005771multivesicular bodyIEA
GO:0042599lamellar bodyIEA
GeneCards SFTPB
PDB 1SSZ, 1RG3, 1DFW, 1RG4, 2JOU, 2DWF, 1KMR
UniProt P07988, D6W5L6
MIM 178640
Ensembl ENSG00000168878
HGNC 10801
HPRD 01523

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