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SFTPC surfactant protein C [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001172357 Homo sapiens surfactant protein C (SFTPC), transcript variant 3, mRNA. ORF Sequence $167.04
Peptide Services
Antibody Services
Protein Services
NM_001172410 Homo sapiens surfactant protein C (SFTPC), transcript variant 2, mRNA. ORF Sequence $172.26
Peptide Services
Antibody Services
Protein Services
NM_003018 Homo sapiens surfactant protein C (SFTPC), transcript variant 1, mRNA. ORF Sequence $172.26
Peptide Services
Antibody Services
Protein Services


Gene Symbol SFTPC
Entrez Gene ID 6440
Full Name surfactant protein C
Synonyms PSP-C, SFTP2, SMDP2, SP-C
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p21

Summary This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010].
Disorder

MIM: 178620

Surfactant metabolism dysfunction, pulmonary, 2, 610913 (3)

mRNA Protein Product Sequence Price Select
NM_001172357, 288915542 NP_001165828, 288915543 pulmonary surfactant-associated protein C isoform 2 proprotein Full Length $344.23
ORF Sequence $167.04
NM_001172410, 288915520 NP_001165881, 288915521 pulmonary surfactant-associated protein C isoform 1 proprotein Full Length $287.39
ORF Sequence $172.26
NM_003018, 149999607 NP_003009, 149999608 pulmonary surfactant-associated protein C isoform 1 proprotein Full Length $286.81
ORF Sequence $172.26
Homo sapiens (human)SFTPCNP_003009.2
Pan troglodytes (chimpanzee)SFTPCXP_519645.2
Macaca mulatta (Rhesus monkey)SFTPCNP_001036224.1
Canis lupus familiaris (dog)SFTPCXP_534578.3
Bos taurus (cattle)SFTPCNP_776887.1
Mus musculus (house mouse)SftpcNP_035489.2
Rattus norvegicus (Norway rat)SftpcNP_059038.1
GeneCards SFTPC
PDB 2YAD
UniProt E9PGX3, P11686
MIM 178620
Ensembl ENSG00000168484
HGNC 10802
HPRD 01520

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
pulmonary surfactant-associated protein C
Names
pulmonary surfactant-associated protein C
SP5
BRICHOS domain containing 6
pulmonary surfactant apoprotein-2 SP-C
pulmonary surfactant-associated proteolipid SPL(Val)

Interactant

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