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SFTPC surfactant protein C [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001172357 Homo sapiens surfactant protein C (SFTPC), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001172410 Homo sapiens surfactant protein C (SFTPC), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_003018 Homo sapiens surfactant protein C (SFTPC), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_005273598 PREDICTED: Homo sapiens surfactant protein C (SFTPC), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006716379 PREDICTED: Homo sapiens surfactant protein C (SFTPC), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006716380 PREDICTED: Homo sapiens surfactant protein C (SFTPC), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol SFTPC
Entrez Gene ID 6440
Full Name surfactant protein C
Synonyms BRICD6, PSP-C, SFTP2, SMDP2, SP-C
General protein information
Preferred Names
pulmonary surfactant-associated protein C
Names
pulmonary surfactant-associated protein C
SP5
BRICHOS domain containing 6
pulmonary surfactant apoprotein-2 SP-C
pulmonary surfactant-associated proteolipid SPL(Val)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p21

Summary This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010].
Disorder

MIM: 178620

Surfactant metabolism dysfunction, pulmonary, 2, 610913 (3)

mRNA Protein Product Sequence Price Select
NM_001172357, 288915542 NP_001165828, 288915543 pulmonary surfactant-associated protein C isoform 2 proprotein ORF Sequence $250.00
NM_001172410, 288915520 NP_001165881, 288915521 pulmonary surfactant-associated protein C isoform 1 proprotein ORF Sequence $250.00
NM_003018, 149999607 NP_003009, 149999608 pulmonary surfactant-associated protein C isoform 1 proprotein ORF Sequence $250.00
XM_005273598, 530387965 XP_005273655, 530387966 pulmonary surfactant-associated protein C isoform X1 ORF Sequence $300.00
XM_006716379, 578815432 XP_006716442, 578815433 pulmonary surfactant-associated protein C isoform X2 ORF Sequence $250.00
XM_006716380, 578815434 XP_006716443, 578815435 pulmonary surfactant-associated protein C isoform X3 ORF Sequence $250.00
Homo sapiens (human)SFTPCNP_001165881.1
Pan troglodytes (chimpanzee)SFTPCXP_519645.2
Macaca mulatta (Rhesus monkey)SFTPCNP_001036224.1
Canis lupus familiaris (dog)SFTPCXP_534578.4
Bos taurus (cattle)SFTPCNP_776887.1
Mus musculus (house mouse)SftpcNP_035489.2
Rattus norvegicus (Norway rat)SftpcNP_059038.1
Xenopus (Silurana) tropicalis (western clawed frog)sftpcNP_001122132.2
Process
IDNameEvidence
GO:0007585respiratory gaseous exchangeIEA
GO:0007623circadian rhythmIEA
GO:0009749response to glucoseIEA
GO:0032496response to lipopolysaccharideIEA
GO:0032526response to retinoic acidIEA
GO:0033189response to vitamin AIEA
GO:0051260protein homooligomerizationIEA
GO:0051384response to glucocorticoidIEA
GO:0051591response to cAMPIEA
GO:0055093response to hyperoxiaIEA
GO:0070741response to interleukin-6IEA
GO:0070848response to growth factorIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0071732cellular response to nitric oxideIEA
Component
IDNameEvidence
GO:0005615extracellular spaceIEA
GO:0005771multivesicular bodyIEA
GO:0097208alveolar lamellar bodyIEA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0042803protein homodimerization activityIEA
GeneCards SFTPC
PDB 2YAD
UniProt P11686
Vega OTTHUMG00000163775
MIM 178620
Ensembl ENSG00000168484
HGNC 10802
HPRD 01520

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SFTPC gene?

The SFTPC gene provides instructions for making a protein called surfactant protein-C (SP-C). This protein is one of four proteins (each produced from a different gene) in surfactant, a mixture of certain fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. Without normal surfactant, the tissue surrounding the air sacs in the lungs (the alveoli) sticks together after exhalation (because of a force called surface tension), causing the alveoli to collapse. As a result, filling the lungs with air on each breath becomes very difficult, and the delivery of oxygen to the body is impaired. Surfactant lowers surface tension, easing breathing and avoiding lung collapse. The SP-C protein helps spread the surfactant across the surface of the lung tissue, aiding in the surface tension-lowering property of surfactant.

The phospholipids and proteins that make up surfactant are packaged in cellular structures known as lamellar bodies, which are found in specialized lung cells. The surfactant proteins must go through several processing steps to mature and become functional; some of these steps occur in lamellar bodies.

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