• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000232 Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10
XM_006714046 PREDICTED: Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006714047 PREDICTED: Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006714048 PREDICTED: Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006714049 PREDICTED: Homo sapiens sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $399.00 14

*Business Day

Related Services

Gene Symbol SGCB
Entrez Gene ID 6443
Full Name sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Synonyms A3b, LGMD2E, SGC
General protein information
Preferred Names
beta-sarcoglycan
Names
beta-sarcoglycan
43DAG
beta-SG
43 kDa dystrophin-associated glycoprotein
limb girdle muscular dystrophy 2E (non-linked families)
beta-sarcoglycan(43kD dystrophin-associated glycoprotein)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q12

Summary This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008].
Disorder

MIM: 600900

Muscular dystrophy, limb-girdle, type 2E, 604286 (3)

mRNA Protein Product Sequence Price Select
NM_000232, 209693454 NP_000223, 4506913 beta-sarcoglycan ORF Sequence $269.00
XM_006714046, 578808651 XP_006714109, 578808652 beta-sarcoglycan isoform X1 ORF Sequence $300.00
XM_006714047, 578808653 XP_006714110, 578808654 beta-sarcoglycan isoform X2 ORF Sequence $300.00
XM_006714048, 578808655 XP_006714111, 578808656 beta-sarcoglycan isoform X3 ORF Sequence $300.00
XM_006714049, 578808657 XP_006714112, 578808658 beta-sarcoglycan isoform X4 ORF Sequence $250.00
KEGG
hsa05416Viral myocarditis
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
WikiPathways
WP2118Arrhythmogenic right ventricular cardiomyopathy
Homo sapiens (human)SGCBNP_000223.1
Pan troglodytes (chimpanzee)SGCBXP_517299.2
Macaca mulatta (Rhesus monkey)SGCBXP_001090970.1
Canis lupus familiaris (dog)SGCBXP_853790.1
Bos taurus (cattle)SGCBNP_001095658.1
Mus musculus (house mouse)SgcbNP_036020.1
Rattus norvegicus (Norway rat)SgcbNP_001177997.1
Gallus gallus (chicken)SGCBNP_001026326.1
Danio rerio (zebrafish)sgcbNP_001030145.1
Xenopus (Silurana) tropicalis (western clawed frog)sgcbNP_001135484.1
Process
IDNameEvidence
GO:0007517muscle organ developmentIEA
GO:0035051cardiocyte differentiationIEA
Component
IDNameEvidence
GO:0005737cytoplasmIEA
GO:0005856cytoskeletonIEA
GO:0005887integral component of plasma membraneTAS
GO:0016010dystrophin-associated glycoprotein complexIDA
GO:0016012sarcoglycan complexIEA
GO:0042383sarcolemmaIEA
GeneCards SGCB
UniProt Q16585, Q5U0N0
Vega OTTHUMG00000128697
MIM 600900
Ensembl ENSG00000163069
HGNC 10806
HPRD 02942

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SGCB gene?

The SGCB gene provides instructions for making the beta component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.