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Sequence in raw or FASTA format:

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SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000231 Homo sapiens sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (SGCG), mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005266505 PREDICTED: Homo sapiens sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (SGCG), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006719861 PREDICTED: Homo sapiens sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (SGCG), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $449.00 14

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Related Services

Gene Symbol SGCG
Entrez Gene ID 6445
Full Name sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
Synonyms A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, TYPE
General protein information
Preferred Names
gamma-sarcoglycan
Names
gamma-sarcoglycan
35DAG
gamma-SG
gamma sarcoglycan
35kD dystrophin-associated glycoprotein
35 kDa dystrophin-associated glycoprotein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q12

Summary This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008].
Disorder

MIM: 608896

Muscular dystrophy, limb-girdle, type 2C, 253700 (3)

mRNA Protein Product Sequence Price Select
NM_000231, 209529740 NP_000222, 4557847 gamma-sarcoglycan ORF Sequence $300.00
XM_005266505, 530402603 XP_005266562, 530402604 gamma-sarcoglycan isoform X1 ORF Sequence $300.00
XM_006719861, 578824991 XP_006719924, 578824992 gamma-sarcoglycan isoform X2 ORF Sequence $300.00
KEGG
hsa05416Viral myocarditis
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05410Hypertrophic cardiomyopathy (HCM)
WikiPathways
WP2118Arrhythmogenic right ventricular cardiomyopathy
Homo sapiens (human)SGCGNP_000222.1
Pan troglodytes (chimpanzee)SGCGXP_001151216.1
Macaca mulatta (Rhesus monkey)LOC721411XP_001117551.2
Canis lupus familiaris (dog)SGCGNP_001014298.1
Bos taurus (cattle)SGCGNP_001068712.1
Mus musculus (house mouse)SgcgNP_036022.1
Rattus norvegicus (Norway rat)SgcgNP_001006994.1
Gallus gallus (chicken)SGCGXP_417139.2
Danio rerio (zebrafish)sgcgNP_001003748.1
Danio rerio (zebrafish)LOC100538014XP_003200060.1
Xenopus (Silurana) tropicalis (western clawed frog)sgcgNP_001072908.1
Process
IDNameEvidence
GO:0007517muscle organ developmentTAS
Component
IDNameEvidence
GO:0005737cytoplasmIEA
GO:0005856cytoskeletonIEA
GO:0005886plasma membraneTAS
GO:0016012sarcoglycan complexIEA
GO:0016021integral component of membraneIEA
GO:0042383sarcolemmaIEA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GeneCards SGCG
UniProt Q13326
Vega OTTHUMG00000016563
MIM 608896
Ensembl ENSG00000102683
HGNC 10809
HPRD 07039

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SGCG gene?

The SGCG gene provides instructions for making the gamma component (subunit) of a group of proteins called the sarcoglycan protein complex. The sarcoglycan protein complex is located in the membrane surrounding muscle cells. It helps maintain the structure of muscle tissue by attaching (binding) to and stabilizing the dystrophin complex, which is made up of proteins called dystrophins and dystroglycans. The large dystrophin complex strengthens muscle fibers and protects them from injury as muscles tense (contract) and relax. It acts as an anchor, connecting each muscle cell's structural framework (cytoskeleton) with the lattice of proteins and other molecules outside the cell (extracellular matrix).

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