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SKI SKI proto-oncogene [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22092 NM_003036 Homo sapiens v-ski avian sarcoma viral oncogene homolog (SKI), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu33714 XM_005244775 PREDICTED: Homo sapiens v-ski avian sarcoma viral oncogene homolog (SKI), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu33715 XM_005244776 PREDICTED: Homo sapiens v-ski avian sarcoma viral oncogene homolog (SKI), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu22092C NM_003036 Homo sapiens v-ski avian sarcoma viral oncogene homolog (SKI), mRNA. Customized vector On-demand 12-14 $329.00
OHu33714C XM_005244775 PREDICTED: Homo sapiens v-ski avian sarcoma viral oncogene homolog (SKI), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu33715C XM_005244776 PREDICTED: Homo sapiens v-ski avian sarcoma viral oncogene homolog (SKI), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

*Business Day

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Gene Symbol SKI
Entrez Gene ID 6497
Full Name SKI proto-oncogene
Synonyms SGS, SKV
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.33

Summary This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009].
Disorder

MIM: 164780

mRNA Protein Product Sequence Price Select
NM_003036, 224465161 NP_003027, 4506967 ski oncogene ORF Sequence $700.00
XM_005244775, 530360371 XP_005244832, 530360372 ski oncogene isoform X1 ORF Sequence $700.00
XM_005244776, 578799619 XP_005244833, 530360374 ski oncogene isoform X2 ORF Sequence $550.00
WikiPathways
WP366TGF-beta Receptor Signaling Pathway
WP560TGF Beta Signaling Pathway
WP47Hedgehog Signaling Pathway
Pathway Interaction Database
smad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
bmppathwayBMP receptor signaling
cmyb_pathwayC-MYB transcription factor network
BIOCYC
HUMAN_PWY66-11BMP Signalling Pathway
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_12034Signaling by BMP
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_111102Signal Transduction
REACT_116125Disease
REACT_121111Downregulation of SMAD2/3:SMAD4 transcriptional activity
REACT_121061Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
REACT_169103SMAD2/3 Phosphorylation Motif Mutants in Cancer
REACT_169192TGFBR2 MSI Frameshift Mutants in Cancer
REACT_169440TGFBR2 Kinase Domain Mutants in Cancer
REACT_169165SMAD2/3 MH2 Domain Mutants in Cancer
REACT_169107SMAD4 MH2 Domain Mutants in Cancer
REACT_169311Loss of Function of TGFBR1 in Cancer
REACT_169122Signaling by TGF-beta Receptor Complex in Cancer
REACT_169263TGFBR1 KD Mutants in Cancer
REACT_169435Loss of Function of TGFBR2 in Cancer
REACT_169219Loss of Function of SMAD4 in Cancer
REACT_169398Loss of Function of SMAD2/3 in Cancer
REACT_169445TGFBR1 LBD Mutants in Cancer
Homo sapiens (human)SKINP_003027.1
Macaca mulatta (Rhesus monkey)SKIXP_001086434.1
Canis lupus familiaris (dog)SKIXP_005620652.1
Bos taurus (cattle)SKIXP_002694226.2
Mus musculus (house mouse)SkiNP_035515.2
Rattus norvegicus (Norway rat)SkiXP_006239683.1
Gallus gallus (chicken)SKINP_001034407.1
Danio rerio (zebrafish)skiaNP_571010.2
Xenopus (Silurana) tropicalis (western clawed frog)skiXP_004916211.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMP
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS
GO:0001843neural tube closureISS
GO:0002089lens morphogenesis in camera-type eyeISS
GO:0006351transcription, DNA-templatedISS
GO:0006351transcription, DNA-templatedTAS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0007179transforming growth factor beta receptor signaling pathwayNAS
GO:0007179transforming growth factor beta receptor signaling pathwayTAS
GO:0008283cell proliferationNAS
GO:0008285negative regulation of cell proliferationIDA
GO:0009948anterior/posterior axis specificationISS
GO:0010467gene expressionTAS
GO:0010626negative regulation of Schwann cell proliferationIGI
GO:0014902myotube differentiationIDA
GO:0021772olfactory bulb developmentISS
GO:0022011myelination in peripheral nervous systemISS
GO:0030177positive regulation of Wnt signaling pathwayNAS
GO:0030326embryonic limb morphogenesisISS
GO:0030509BMP signaling pathwayTAS
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIDA
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIGI
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0030514negative regulation of BMP signaling pathwayIDA
GO:0030514negative regulation of BMP signaling pathwayIMP
GO:0031064negative regulation of histone deacetylationIEA
GO:0032926negative regulation of activin receptor signaling pathwayIDA
GO:0035019somatic stem cell maintenanceISS
GO:0042981regulation of apoptotic processIBA
GO:0042981regulation of apoptotic processISS
GO:0043010camera-type eye developmentISS
GO:0043388positive regulation of DNA bindingIDA
GO:0043585nose morphogenesisISS
GO:0045668negative regulation of osteoblast differentiationIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0048147negative regulation of fibroblast proliferationISS
GO:0048593camera-type eye morphogenesisISS
GO:0048741skeletal muscle fiber developmentISS
GO:0048870cell motilityNAS
GO:0060021palate developmentISS
GO:0060041retina development in camera-type eyeISS
GO:0060325face morphogenesisISS
GO:0060349bone morphogenesisISS
GO:0060395SMAD protein signal transductionIDA
GO:0070207protein homotrimerizationIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005667transcription factor complexISS
GO:0005737cytoplasmIBA
GO:0005737cytoplasmISS
GO:0005813centrosomeIDA
GO:0016604nuclear bodyIDA
GO:0016605PML bodyIDA
GO:0017053transcriptional repressor complexISS
GO:0043234protein complexIDA
Function
IDNameEvidence
GO:0003682chromatin bindingIEA
GO:0003714transcription corepressor activityIDA
GO:0003714transcription corepressor activityIMP
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingIDA
GO:0019901protein kinase bindingIPI
GO:0019904protein domain specific bindingIPI
GO:0031625ubiquitin protein ligase bindingIPI
GO:0046332SMAD bindingIPI
GO:0046811histone deacetylase inhibitor activityISS
GO:0070491repressing transcription factor bindingIPI
GeneCards SKI
PDB 1MR1, 1SBX
UniProt P12755
Vega OTTHUMG00000001407
MIM 164780
Ensembl ENSG00000157933
HGNC 10896
HPRD 01271

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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