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BMP2 bone morphogenetic protein 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18169 NM_001200 Homo sapiens bone morphogenetic protein 2 (BMP2), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18169C NM_001200 Homo sapiens bone morphogenetic protein 2 (BMP2), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol BMP2
Entrez Gene ID 650
Full Name bone morphogenetic protein 2
Synonyms BDA2, BMP2A
General protein information
Preferred Names
bone morphogenetic protein 2
Names
bone morphogenetic protein 2
BMP-2A
bone morphogenetic protein 2A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20p12

Summary The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008].
Disorder

MIM: 112261

{HFE hemochromatosis, modifier of}, 235200 (3)

mRNA Protein Product Sequence Price Select
NM_001200, 80861484 NP_001191, 4557369 bone morphogenetic protein 2 preproprotein ORF Sequence $269.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04340Hedgehog signaling pathway
hsa04350TGF-beta signaling pathway
hsa05217Basal cell carcinoma
hsa05200Pathways in cancer
hsa04390Hippo signaling pathway
WikiPathways
WP615Senescence and Autophagy
WP1591Heart Development
WP236Adipogenesis
WP1425BMP signalling and regulation
WP53Id Signaling Pathway
WP2380BDNF signaling pathway
Reactome
REACT_12034Signaling by BMP
REACT_111102Signal Transduction
REACT_118779Extracellular matrix organization
REACT_150366Elastic fibre formation
REACT_150331Molecules associated with elastic fibres
Homo sapiens (human)BMP2NP_001191.1
Pan troglodytes (chimpanzee)BMP2XP_514508.2
Macaca mulatta (Rhesus monkey)BMP2XP_001115987.1
Canis lupus familiaris (dog)BMP2XP_534351.2
Bos taurus (cattle)BMP2NP_001092611.1
Mus musculus (house mouse)Bmp2NP_031579.2
Rattus norvegicus (Norway rat)Bmp2NP_058874.1
Gallus gallus (chicken)BMP2NP_989689.1
Danio rerio (zebrafish)bmp2aNP_571434.1
Danio rerio (zebrafish)bmp2bNP_571435.1
Drosophila melanogaster (fruit fly)dppNP_477311.1
Xenopus (Silurana) tropicalis (western clawed frog)bmp2NP_001015963.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000187activation of MAPK activityIDA
GO:0001501skeletal system developmentTAS
GO:0001649osteoblast differentiationIDA
GO:0001658branching involved in ureteric bud morphogenesisISS
GO:0001666response to hypoxiaISS
GO:0001701in utero embryonic developmentISS
GO:0001837epithelial to mesenchymal transitionIDA
GO:0001934positive regulation of protein phosphorylationIDA
GO:0001938positive regulation of endothelial cell proliferationIDA
GO:0002062chondrocyte differentiationIDA
GO:0003130BMP signaling pathway involved in heart inductionIDA
GO:0003181atrioventricular valve morphogenesisISS
GO:0003203endocardial cushion morphogenesisISS
GO:0003308negative regulation of Wnt signaling pathway involved in heart developmentIDA
GO:0006029proteoglycan metabolic processIEA
GO:0006355regulation of transcription, DNA-templatedIDA
GO:0006468protein phosphorylationIDA
GO:0006954inflammatory responseISS
GO:0007219Notch signaling pathwayISS
GO:0007267cell-cell signalingTAS
GO:0007507heart developmentISS
GO:0008285negative regulation of cell proliferationIDA
GO:0009790embryo developmentISS
GO:0009887organ morphogenesisISS
GO:0010628positive regulation of gene expressionIDA
GO:0010718positive regulation of epithelial to mesenchymal transitionIDA
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylationIDA
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylationIMP
GO:0010894negative regulation of steroid biosynthetic processIDA
GO:0010922positive regulation of phosphatase activityIDA
GO:0021537telencephalon developmentIDA
GO:0021978telencephalon regionalizationISS
GO:0030177positive regulation of Wnt signaling pathwayISS
GO:0030198extracellular matrix organizationTAS
GO:0030282bone mineralizationISS
GO:0030335positive regulation of cell migrationISS
GO:0030501positive regulation of bone mineralizationIDA
GO:0030509BMP signaling pathwayIDA
GO:0030509BMP signaling pathwayIEP
GO:0030509BMP signaling pathwayIMP
GO:0030509BMP signaling pathwayTAS
GO:0031648protein destabilizationIEA
GO:0032348negative regulation of aldosterone biosynthetic processIDA
GO:0033690positive regulation of osteoblast proliferationISS
GO:0035051cardiocyte differentiationIDA
GO:0035051cardiocyte differentiationIMP
GO:0035054embryonic heart tube anterior/posterior pattern specificationISS
GO:0035630bone mineralization involved in bone maturationIDA
GO:0040007growthIEA
GO:0042475odontogenesis of dentin-containing toothISS
GO:0042482positive regulation of odontogenesisISS
GO:0042487regulation of odontogenesis of dentin-containing toothIEA
GO:0043065positive regulation of apoptotic processIDA
GO:0043410positive regulation of MAPK cascadeIDA
GO:0043569negative regulation of insulin-like growth factor receptor signaling pathwayIDA
GO:0045165cell fate commitmentISS
GO:0045600positive regulation of fat cell differentiationISS
GO:0045666positive regulation of neuron differentiationISS
GO:0045669positive regulation of osteoblast differentiationIDA
GO:0045778positive regulation of ossificationIDA
GO:0045786negative regulation of cell cycleIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048711positive regulation of astrocyte differentiationISS
GO:0048762mesenchymal cell differentiationIDA
GO:0048839inner ear developmentISS
GO:0051042negative regulation of calcium-independent cell-cell adhesionIDA
GO:0055007cardiac muscle cell differentiationIMP
GO:0055008cardiac muscle tissue morphogenesisISS
GO:0055114oxidation-reduction processIEA
GO:0055114oxidation-reduction processISS
GO:0060039pericardium developmentISS
GO:0060128corticotropin hormone secreting cell differentiationISS
GO:0060129thyroid-stimulating hormone-secreting cell differentiationISS
GO:0060317cardiac epithelial to mesenchymal transitionIDA
GO:0060389pathway-restricted SMAD protein phosphorylationIDA
GO:0060395SMAD protein signal transductionIDA
GO:0060485mesenchyme developmentIMP
GO:0060804positive regulation of Wnt signaling pathway by BMP signaling pathwayISS
GO:0061036positive regulation of cartilage developmentIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMP
GO:0071407cellular response to organic cyclic compoundIEA
GO:0071773cellular response to BMP stimulusIDA
GO:0072138mesenchymal cell proliferation involved in ureteric bud developmentISS
GO:0090090negative regulation of canonical Wnt signaling pathwayIEP
GO:1900745positive regulation of p38MAPK cascadeIDA
GO:1901522positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusIDA
GO:2000065negative regulation of cortisol biosynthetic processIDA
GO:2000726negative regulation of cardiac muscle cell differentiationIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0009986cell surfaceIDA
Function
IDNameEvidence
GO:0004745retinol dehydrogenase activityISS
GO:0005102receptor bindingTAS
GO:0005125cytokine activityIEA
GO:0005515protein bindingIPI
GO:0008083growth factor activityIEA
GO:0019211phosphatase activator activityIDA
GO:0046332SMAD bindingIDA
GO:0046982protein heterodimerization activityIDA
GO:0070700BMP receptor bindingIDA
GeneCards BMP2
PDB 4N1D, 2GOO, 2QJB, 1REU, 1ES7, 2H64, 2QJA, 3BK3, 1REW, 3BMP, 2QJ9, 2H62, 4MID
UniProt C8C060, P12643
Vega OTTHUMG00000031833
MIM 112261
Ensembl ENSG00000125845
HGNC 1069
HPRD 00206

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