Sequence in raw or FASTA format:
PINK1 PTEN induced putative kinase 1 [Homo sapiens (human)]
| Gene Symbol | PINK1 |
| Entrez Gene ID | 65018 |
| Full Name | PTEN induced putative kinase 1 |
| Synonyms | BRPK, FLJ27236, PARK6 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
1 1p36 |
| Summary | This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq]. |
| Disorder | MIM: 608309 Parkinson disease 6, early onset, 605909 (3) |
| mRNA | NM_032409, 112382374 |
| Protein | NP_115785, 14165272 |
| Product | serine/threonine-protein kinase PINK1, mitochondrial precursor |
| RefSeq Status | REVIEWED |
| hsa05012 | Parkinson's disease |
| Homo sapiens (human) | PINK1 | NP_115785.1 |
| Pan troglodytes (chimpanzee) | PINK1 | XP_001164912.1 |
| Bos taurus (cattle) | PINK1 | NP_001093171.1 |
| Mus musculus (house mouse) | Pink1 | NP_081156.2 |
| Rattus norvegicus (Norway rat) | Pink1 | XP_216565.2 |
| Gallus gallus (chicken) | PINK1 | XP_423139.2 |
| Danio rerio (zebrafish) | pink1 | NP_001008628.1 |
| Caenorhabditis elegans | pink-1 | NP_495017.1 |
| ID | Name | Evidence |
| GO:0000422 | mitochondrion degradation | IMP |
| GO:0006468 | protein phosphorylation | IDA |
| GO:0006950 | response to stress | IDA |
| GO:0007243 | intracellular protein kinase cascade | IDA |
| GO:0008219 | cell death | IEA |
| GO:0018105 | peptidyl-serine phosphorylation | IDA |
| GO:0031396 | regulation of protein ubiquitination | IDA |
| GO:0032226 | positive regulation of synaptic transmission, dopaminergic | IEA |
| GO:0033603 | positive regulation of dopamine secretion | IEA |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | IDA |
| GO:0043254 | regulation of protein complex assembly | IDA |
| GO:0090200 | positive regulation of release of cytochrome c from mitochondria | IMP |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005739 | mitochondrion | IDA |
| GO:0005741 | mitochondrial outer membrane | IEA |
| GO:0005743 | mitochondrial inner membrane | IEA |
| GO:0005829 | cytosol | IDA |
| GO:0016020 | membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0000287 | magnesium ion binding | IDA |
| GO:0004674 | protein serine/threonine kinase activity | IDA |
| GO:0005524 | ATP binding | IDA |
| GO:0010857 | calcium-dependent protein kinase activity | IDA |
| GO:0016301 | kinase activity | IDA |
| GO:0031625 | ubiquitin protein ligase binding | IPI |
| GO:0055131 | C3HC4-type RING finger domain binding | IPI |
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