• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


PINK1 PTEN induced putative kinase 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25380 NM_032409 Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25380C NM_032409 Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA. Customized vector On-demand 7-9 $269.00

*Business Day

Related Services

Gene Symbol PINK1
Entrez Gene ID 65018
Full Name PTEN induced putative kinase 1
Synonyms BRPK, PARK6
General protein information
Preferred Names
serine/threonine-protein kinase PINK1, mitochondrial
Names
serine/threonine-protein kinase PINK1, mitochondrial
protein kinase BRPK
PTEN-induced putative kinase protein 1
NP_115785.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36

Summary This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].
Disorder

MIM: 608309

Parkinson disease 6, early onset, 605909 (3)

mRNA Protein Product Sequence Price Select
NM_032409, 112382374 NP_115785, 14165272 serine/threonine-protein kinase PINK1, mitochondrial precursor ORF Sequence $700.00
KEGG
hsa05012Parkinson's disease
WikiPathways
WP2371Parkinsons Disease Pathway
Homo sapiens (human)PINK1NP_115785.1
Pan troglodytes (chimpanzee)PINK1XP_001164912.2
Macaca mulatta (Rhesus monkey)LOC698013XP_001086306.1
Macaca mulatta (Rhesus monkey)PINK1XP_001096957.1
Canis lupus familiaris (dog)PINK1XP_005617989.1
Bos taurus (cattle)PINK1NP_001093171.1
Mus musculus (house mouse)Pink1NP_081156.2
Rattus norvegicus (Norway rat)Pink1NP_001100164.1
Gallus gallus (chicken)PINK1XP_423139.3
Danio rerio (zebrafish)pink1NP_001008628.1
Caenorhabditis eleganspink-1NP_495017.1
Process
IDNameEvidence
GO:0000422mitochondrion degradationIMP
GO:0006468protein phosphorylationIDA
GO:0006950response to stressIDA
GO:0008219cell deathIEA
GO:0016567protein ubiquitinationIMP
GO:0018105peptidyl-serine phosphorylationIDA
GO:0031396regulation of protein ubiquitinationIDA
GO:0032226positive regulation of synaptic transmission, dopaminergicIEA
GO:0033603positive regulation of dopamine secretionIEA
GO:0035556intracellular signal transductionIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDA
GO:0043254regulation of protein complex assemblyIDA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0090200positive regulation of release of cytochrome c from mitochondriaIMP
GO:0097237cellular response to toxic substanceIEA
GO:1902176negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIDA
Component
IDNameEvidence
GO:0000785chromatinIDA
GO:0005634nucleusIDA
GO:0005739mitochondrionIDA
GO:0005741mitochondrial outer membraneIEA
GO:0005743mitochondrial inner membraneIDA
GO:0005758mitochondrial intermembrane spaceIDA
GO:0005829cytosolIDA
GO:0005856cytoskeletonIDA
GO:0016020membraneIDA
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0000287magnesium ion bindingIDA
GO:0004674protein serine/threonine kinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0010857calcium-dependent protein kinase activityIDA
GO:0016301kinase activityIDA
GO:0031625ubiquitin protein ligase bindingIPI
GO:0055131C3HC4-type RING finger domain bindingIPI
GeneCards PINK1
UniProt Q9BXM7
Vega OTTHUMG00000002841
MIM 608309
Ensembl ENSG00000158828
HGNC 14581
HPRD 10514

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.