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Sequence in raw or FASTA format:


Blast Method:


PINK1 PTEN induced putative kinase 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_032409 Homo sapiens PTEN induced putative kinase 1 (PINK1), mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

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Gene Symbol PINK1
Entrez Gene ID 65018
Full Name PTEN induced putative kinase 1
Synonyms BRPK, PARK6
General protein information
Preferred Names
serine/threonine-protein kinase PINK1, mitochondrial
serine/threonine-protein kinase PINK1, mitochondrial
protein kinase BRPK
PTEN-induced putative kinase protein 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].

MIM: 608309

Parkinson disease 6, early onset, 605909 (3)

mRNA Protein Product Sequence Price Select
NM_032409, 112382374 NP_115785, 14165272 serine/threonine-protein kinase PINK1, mitochondrial precursor ORF Sequence $700.00
hsa05012Parkinson's disease
WP2371Parkinsons Disease Pathway
Homo sapiens (human)PINK1NP_115785.1
Pan troglodytes (chimpanzee)PINK1XP_001164912.2
Macaca mulatta (Rhesus monkey)LOC698013XP_001086306.1
Macaca mulatta (Rhesus monkey)PINK1XP_001096957.1
Canis lupus familiaris (dog)PINK1XP_005617989.1
Bos taurus (cattle)PINK1NP_001093171.1
Mus musculus (house mouse)Pink1NP_081156.2
Rattus norvegicus (Norway rat)Pink1NP_001100164.1
Gallus gallus (chicken)PINK1XP_423139.3
Danio rerio (zebrafish)pink1NP_001008628.1
Caenorhabditis eleganspink-1NP_495017.1
GO:0000422mitochondrion degradationIMP
GO:0006468protein phosphorylationIDA
GO:0006950response to stressIDA
GO:0008219cell deathIEA
GO:0016567protein ubiquitinationIMP
GO:0018105peptidyl-serine phosphorylationIDA
GO:0031396regulation of protein ubiquitinationIDA
GO:0032226positive regulation of synaptic transmission, dopaminergicIEA
GO:0033603positive regulation of dopamine secretionIEA
GO:0035556intracellular signal transductionIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIDA
GO:0043254regulation of protein complex assemblyIDA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0090200positive regulation of release of cytochrome c from mitochondriaIMP
GO:0097237cellular response to toxic substanceIEA
GO:1902176negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressIDA
GO:0005741mitochondrial outer membraneIEA
GO:0005743mitochondrial inner membraneIDA
GO:0005758mitochondrial intermembrane spaceIDA
GO:0016021integral component of membraneIEA
GO:0000287magnesium ion bindingIDA
GO:0004674protein serine/threonine kinase activityIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0010857calcium-dependent protein kinase activityIDA
GO:0016301kinase activityIDA
GO:0031625ubiquitin protein ligase bindingIPI
GO:0055131C3HC4-type RING finger domain bindingIPI
GeneCards PINK1
UniProt Q9BXM7
Vega OTTHUMG00000002841
MIM 608309
Ensembl ENSG00000158828
HGNC 14581
HPRD 10514

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the PINK1 gene?

The PINK1 gene provides instructions for making a protein called PTEN induced putative kinase 1. This protein is found in cells throughout the body, with highest levels in the heart, muscles, and testes. Within cells, the protein is located in the mitochondria, the energy-producing centers that provide power for cellular activities. The function of PTEN induced putative kinase 1 is not fully understood. It appears to help protect mitochondria from malfunctioning during periods of cellular stress, such as unusually high energy demands.

Researchers believe that two specialized regions of PTEN induced putative kinase 1 are essential for the protein to function properly. One region, called the mitochondrial-targeting motif, serves as a delivery address: after the protein is made, this motif helps ensure that it is delivered to the mitochondria. Another region, called the kinase domain, probably carries out the protein's protective function.


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