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SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000340 Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2), mRNA. Full Length $1203.65
ORF Sequence $456.75


Gene Symbol SLC2A2
Entrez Gene ID 6514
Full Name solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms GLUT2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3q26.1-q26.2
Summary Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. [provided by RefSeq].
Disorder

MIM: 138160

{Diabetes mellitus, noninsulin-dependent} (3); Fanconi-Bickel
mRNA NM_000340, 4557850
Protein NP_000331, 4557851
Product solute carrier family 2, facilitated glucose transporter member 2
RefSeq Status REVIEWED
KEGG
hsa04930Type II diabetes mellitus
hsa04973Carbohydrate digestion and absorption
hsa04950Maturity onset diabetes of the young
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
WikiPathways
WP534Glycolysis and Gluconeogenesis
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_19343Facilitative Na+-independent glucose transporters
REACT_13698Regulation of beta-cell development
REACT_212Glucose transport
REACT_19305Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
REACT_13819Regulation of gene expression in beta cells
REACT_15380Diabetes pathways
REACT_19118SLC-mediated transmembrane transport
REACT_19241Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_15518Transmembrane transport of small molecules
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_18325Regulation of Insulin Secretion
REACT_474Metabolism of carbohydrates
REACT_1505Integration of energy metabolism
REACT_9441Hexose transport
Homo sapiens (human)SLC2A2NP_000331.1
Pan troglodytes (chimpanzee)SLC2A2XP_516875.2
Canis lupus familiaris (dog)SLC2A2XP_545289.2
Bos taurus (cattle)SLC2A2NP_001096692.1
Mus musculus (house mouse)Slc2a2NP_112474.1
Rattus norvegicus (Norway rat)Slc2a2NP_037011.1
Gallus gallus (chicken)SLC2A2NP_997061.1
Danio rerio (zebrafish)slc2a2NP_001036186.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0006112energy reserve metabolic processTAS
GO:0008643carbohydrate transportIEA
GO:0008645hexose transportTAS
GO:0015755fructose transportIEA
GO:0015758glucose transportTAS
GO:0031018endocrine pancreas developmentTAS
GO:0035428hexose transmembrane transportTAS
GO:0044255cellular lipid metabolic processTAS
GO:0050796regulation of insulin secretionTAS
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005624membrane fractionTAS
GO:0005737cytoplasmIEA
GO:0005768endosomeIEA
GO:0005829cytosolIEA
GO:0005886plasma membraneTAS
GO:0005887integral to plasma membraneTAS
GO:0016323basolateral plasma membraneIEA
GO:0031526brush border membraneIEA
Function
IDNameEvidence
GO:0005158insulin receptor bindingIEA
GO:0005355glucose transmembrane transporter activityTAS
GO:0015149hexose transmembrane transporter activityTAS
GO:0022891substrate-specific transmembrane transporter activityIEA
GO:0033300dehydroascorbic acid transporter activityIEA
GO:0055056D-glucose transmembrane transporter activityTAS
GeneCards SLC2A2
UniProt P11168
MIM 138160
Ensembl ENSG00000163581
HGNC 11006
HPRD 00685

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