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SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001042 Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 4 (SLC2A4), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol SLC2A4
Entrez Gene ID 6517
Full Name solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms GLUT4
General protein information
Preferred Names
solute carrier family 2, facilitated glucose transporter member 4
Names
solute carrier family 2, facilitated glucose transporter member 4
GLUT-4
insulin-responsive glucose transporter type 4
glucose transporter type 4, insulin-responsive
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17p13

Summary This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008].
Disorder

MIM: 138190

{Diabetes mellitus, noninsulin-dependent}, 125853 (3)

mRNA Protein Product Sequence Price Select
NM_001042, 83722278 NP_001033, 4507011 solute carrier family 2, facilitated glucose transporter member 4 ORF Sequence $360.00
KEGG
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa04920Adipocytokine signaling pathway
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
WikiPathways
WP534Glycolysis and Gluconeogenesis
WP1584Type II diabetes mellitus
WP481Insulin Signaling
WP236Adipogenesis
WP1403AMPK signaling
Pathway Interaction Database
arf6_traffickingpathwayArf6 trafficking events
insulin_glucose_pathwayInsulin-mediated glucose transport
pi3kciaktpathwayClass I PI3K signaling events mediated by Akt
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_19305Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
REACT_19343Facilitative Na+-independent glucose transporters
REACT_212Glucose transport
REACT_11123Membrane Trafficking
REACT_9441Hexose transport
REACT_474Metabolism of carbohydrates
REACT_15518Transmembrane transport of small molecules
REACT_27161Transcriptional regulation of white adipocyte differentiation
REACT_111217Metabolism
REACT_111045Developmental Biology
REACT_147867Translocation of GLUT4 to the plasma membrane
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)SLC2A4NP_001033.1
Pan troglodytes (chimpanzee)SLC2A4XP_001169794.1
Macaca mulatta (Rhesus monkey)SLC2A4XP_001107391.1
Canis lupus familiaris (dog)SLC2A4NP_001152799.1
Bos taurus (cattle)SLC2A4NP_777029.1
Mus musculus (house mouse)Slc2a4NP_033230.2
Rattus norvegicus (Norway rat)Slc2a4NP_036883.1
Process
IDNameEvidence
GO:0005975carbohydrate metabolic processTAS
GO:0008645hexose transportTAS
GO:0010021amylopectin biosynthetic processIEA
GO:0015758glucose transportTAS
GO:0032869cellular response to insulin stimulusIDA
GO:0042593glucose homeostasisIDA
GO:0044281small molecule metabolic processTAS
GO:0045471response to ethanolIEA
GO:0046323glucose importNAS
GO:0050873brown fat cell differentiationIEA
GO:0055085transmembrane transportTAS
GO:0061024membrane organizationTAS
GO:0071470cellular response to osmotic stressIEA
Component
IDNameEvidence
GO:0005771multivesicular bodyIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIEA
GO:0005905coated pitIEA
GO:0009897external side of plasma membraneIDA
GO:0012505endomembrane systemISS
GO:0012506vesicle membraneIDA
GO:0016020membraneTAS
GO:0030136clathrin-coated vesicleIDA
GO:0030140trans-Golgi network transport vesicleIEA
GO:0032593insulin-responsive compartmentIDA
GO:0032593insulin-responsive compartmentISS
GO:0042383sarcolemmaIEA
GO:0048471perinuclear region of cytoplasmIDA
GO:0070062extracellular vesicular exosomeIEA
Function
IDNameEvidence
GO:0005355glucose transmembrane transporter activityTAS
GO:0005515protein bindingIPI
GO:0055056D-glucose transmembrane transporter activityIEA
GeneCards SLC2A4
UniProt Q05BQ3, P14672
Vega OTTHUMG00000102181
MIM 138190
Ensembl ENSG00000181856
HGNC 11009
HPRD 00688

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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