SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 [Homo sapiens (human)]

Gene Symbol	SLC2A4
Entrez Gene ID	6517
Full Name	solute carrier family 2 (facilitated glucose transporter), member 4
Synonyms	GLUT4
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:17 Map Location:17p13
Summary	This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq].
Disorder	MIM: 138190 {Diabetes mellitus, noninsulin-dependent}, 125853 (3)

mRNA	NM_001042, 83722278
Protein	NP_001033, 4507011
Product	solute carrier family 2, facilitated glucose transporter member 4
RefSeq Status	REVIEWED

KEGG

hsa04920	Adipocytokine signaling pathway
hsa04910	Insulin signaling pathway
hsa04930	Type II diabetes mellitus

Pathway Interaction Database

arf6_traffickingpathway	Arf6 trafficking events
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
insulin_glucose_pathway	Insulin-mediated glucose transport

WikiPathways

WP534	Glycolysis and Gluconeogenesis
WP481	Insulin Signaling
WP236	Adipogenesis
WP1403	AMPK signaling

Reactome

REACT_19343	Facilitative Na+-independent glucose transporters
REACT_212	Glucose transport
REACT_15518	Transmembrane transport of small molecules
REACT_19305	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
REACT_19118	SLC-mediated transmembrane transport
REACT_474	Metabolism of carbohydrates
REACT_9441	Hexose transport

Homo sapiens (human)	SLC2A4	NP_001033.1
Pan troglodytes (chimpanzee)	SLC2A4	XP_001169794.1
Canis lupus familiaris (dog)	SLC2A4	XP_536618.2
Bos taurus (cattle)	SLC2A4	NP_777029.1
Mus musculus (house mouse)	Slc2a4	NP_033230.2
Rattus norvegicus (Norway rat)	Slc2a4	NP_036883.1

Process

ID	Name	Evidence
GO:0005975	carbohydrate metabolic process	TAS
GO:0008643	carbohydrate transport	IEA
GO:0008645	hexose transport	TAS
GO:0015758	glucose transport	TAS
GO:0042593	glucose homeostasis	IDA
GO:0045471	response to ethanol	IEA
GO:0046323	glucose import	NAS
GO:0050873	brown fat cell differentiation	IEA
GO:0055085	transmembrane transport	TAS

Component

ID	Name	Evidence
GO:0000299	integral to membrane of membrane fraction	IEA
GO:0005624	membrane fraction	TAS
GO:0005625	soluble fraction	IEA
GO:0005737	cytoplasm	IEA
GO:0005768	endosome	IEA
GO:0005771	multivesicular body	IEA
GO:0005792	microsome	IEA
GO:0005886	plasma membrane	TAS
GO:0005887	integral to plasma membrane	IEA
GO:0005905	coated pit	IEA
GO:0009897	external side of plasma membrane	IDA
GO:0012506	vesicle membrane	IDA
GO:0030136	clathrin-coated vesicle	IDA
GO:0030140	trans-Golgi network transport vesicle	IEA
GO:0030659	cytoplasmic vesicle membrane	IEA
GO:0031982	vesicle	IEA
GO:0032593	insulin-responsive compartment	IEA
GO:0042383	sarcolemma	IEA
GO:0048471	perinuclear region of cytoplasm	IDA
GO:0070062	extracellular vesicular exosome	IEA

Function

ID	Name	Evidence
GO:0005355	glucose transmembrane transporter activity	TAS
GO:0005515	protein binding	IPI
GO:0022891	substrate-specific transmembrane transporter activity	IEA
GO:0055056	D-glucose transmembrane transporter activity	TAS

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RefSeq Accession	Definition	Sequence	Price	Select
NM_001042	Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 4 (SLC2A4), mRNA.	Full Length	$1105.65
NM_001042		ORF Sequence	$443.70