Sequence in raw or FASTA format:
WNK4 WNK lysine deficient protein kinase 4 [Homo sapiens (human)]
|Entrez Gene ID||65266|
|Full Name||WNK lysine deficient protein kinase 4|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].|
Pseudohypoaldosteronism type II, 145260 (3)
|REACT_15518||Transmembrane transport of small molecules|
|REACT_25300||Ion channel transport|
|Homo sapiens (human)||WNK4||NP_115763.2|
|Pan troglodytes (chimpanzee)||WNK4||XP_003315535.1|
|Macaca mulatta (Rhesus monkey)||LOC707820||XP_002808177.1|
|Canis lupus familiaris (dog)||WNK4||XP_548082.3|
|Bos taurus (cattle)||WNK4||XP_003587489.1|
|Mus musculus (house mouse)||Wnk4||NP_783569.1|
|Rattus norvegicus (Norway rat)||Wnk4||NP_783169.2|
|Gallus gallus (chicken)||LOC777580||XP_003642875.2|
|GO:0035556||intracellular signal transduction||ISS|
|GO:0050794||regulation of cellular process||ISS|
|GO:0070294||renal sodium ion absorption||IMP|
|GO:0072156||distal tubule morphogenesis||IMP|
|GO:0090188||negative regulation of pancreatic juice secretion||IEA|
|GO:0004674||protein serine/threonine kinase activity||ISS|
|GO:0019869||chloride channel inhibitor activity||IDA|
What is the normal function of the WNK4 gene?
The WNK4 gene provides instructions for making a protein that plays a role in blood pressure regulation by helping control the amount of sodium and potassium in the body. The WNK4 protein acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions.
The WNK4 protein regulates channels in the cell membrane that control the transport of sodium or potassium into and out of cells, which occurs primarily in the kidneys. Sodium channels help transport sodium into specialized cells of the kidney, from which it is transferred to the blood. This transfer helps keep sodium in the body through a process called reabsorption. Potassium channels handle excess potassium that has been transferred from the blood into the kidney cells. The channels transport the potassium out of the cells in a process called secretion, so that it can be removed from the body in the urine. The WNK4 protein blocks (inhibits) sodium reabsorption and potassium secretion.
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