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Sequence in raw or FASTA format:

Database:

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WNK4 WNK lysine deficient protein kinase 4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17844 NM_032387 Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu50593 XM_005257595 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu50594 XM_005257596 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu50595 XM_005257597 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu50596 XM_006722020 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X5, mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu50597 XM_005257598 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu50598 XM_006722021 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X6, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu50599 XM_006722022 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X7, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu17844C NM_032387 Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), mRNA. Customized vector On-demand -1 TBD
OHu50593C XM_005257595 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X1, mRNA. Customized vector On-demand -1 TBD
OHu50594C XM_005257596 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X2, mRNA. Customized vector On-demand -1 TBD
OHu50595C XM_005257597 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X3, mRNA. Customized vector On-demand -1 TBD
OHu50596C XM_006722020 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X5, mRNA. Customized vector On-demand -1 TBD
OHu50597C XM_005257598 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X4, mRNA. Customized vector On-demand 12-14 $329.00
OHu50598C XM_006722021 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X6, mRNA. Customized vector On-demand 12-14 $329.00
OHu50599C XM_006722022 PREDICTED: Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant X7, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol WNK4
Entrez Gene ID 65266
Full Name WNK lysine deficient protein kinase 4
Synonyms PHA2B, PRKWNK4
General protein information
Preferred Names
serine/threonine-protein kinase WNK4
Names
serine/threonine-protein kinase WNK4
protein kinase with no lysine 4
protein kinase lysine-deficient 4
NP_115763.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21-q22

Summary This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].
Disorder

MIM: 601844

Pseudohypoaldosteronism type II, 145260 (3)

mRNA Protein Product Sequence Price Select
NM_032387, 260166636 NP_115763, 34365793 serine/threonine-protein kinase WNK4 ORF Sequence $1500.00
XM_005257595, 578831263 XP_005257652, 530412705 serine/threonine-protein kinase WNK4 isoform X1 ORF Sequence $1500.00
XM_005257596, 530412706 XP_005257653, 530412707 serine/threonine-protein kinase WNK4 isoform X2 ORF Sequence $1500.00
XM_005257597, 578831264 XP_005257654, 530412709 serine/threonine-protein kinase WNK4 isoform X3 ORF Sequence $1500.00
XM_005257598, 578831267 XP_005257655, 530412711 serine/threonine-protein kinase WNK4 isoform X4 ORF Sequence $750.00
XM_006722020, 578831265 XP_006722083, 578831266 serine/threonine-protein kinase WNK4 isoform X5 ORF Sequence $1500.00
XM_006722021, 578831268 XP_006722084, 578831269 serine/threonine-protein kinase WNK4 isoform X6 ORF Sequence $750.00
XM_006722022, 578831270 XP_006722085, 578831271 serine/threonine-protein kinase WNK4 isoform X7 ORF Sequence $750.00
Reactome
REACT_15518Transmembrane transport of small molecules
REACT_25300Ion channel transport
REACT_160189Stimuli-sensing channels
Homo sapiens (human)WNK4NP_115763.2
Pan troglodytes (chimpanzee)WNK4XP_003315535.1
Macaca mulatta (Rhesus monkey)LOC707820XP_002808177.1
Canis lupus familiaris (dog)WNK4XP_548082.3
Bos taurus (cattle)WNK4XP_003587489.1
Mus musculus (house mouse)Wnk4NP_783569.1
Rattus norvegicus (Norway rat)Wnk4NP_783169.2
Gallus gallus (chicken)LOC777580XP_003642875.2
Process
IDNameEvidence
GO:0006468protein phosphorylationISS
GO:0006811ion transportISS
GO:0006821chloride transportIEA
GO:0008104protein localizationIEA
GO:0035556intracellular signal transductionISS
GO:0050794regulation of cellular processISS
GO:0050801ion homeostasisIMP
GO:0070294renal sodium ion absorptionIMP
GO:0072156distal tubule morphogenesisIMP
GO:0090188negative regulation of pancreatic juice secretionIEA
Component
IDNameEvidence
GO:0005737cytoplasmIEA
GO:0005923tight junctionISS
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityISS
GO:0005515protein bindingIPI
GO:0005524ATP bindingISS
GO:0019869chloride channel inhibitor activityIDA
GeneCards WNK4
UniProt Q96J92
Vega OTTHUMG00000180650
MIM 601844
Ensembl ENSG00000126562
HGNC 14544
HPRD 03505

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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