WNK4 WNK lysine deficient protein kinase 4 [Homo sapiens (human)]
| Gene Symbol | WNK4 |
| Entrez Gene ID | 65266 |
| Full Name | WNK lysine deficient protein kinase 4 |
| Synonyms | PHA2B, PRKWNK4 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
17 17q21-q22 |
| Summary | This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB. |
| Disorder | MIM: 601844 Pseudohypoaldosteronism type II, 145260 (3) |
| mRNA | NM_032387, 260166636 |
| Protein | NP_115763, 34365793 |
| Product | serine/threonine-protein kinase WNK4 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | WNK4 | NP_115763.2 |
| Bos taurus (cattle) | WNK4 | XP_001790611.1 |
| Mus musculus (house mouse) | Wnk4 | NP_783569.1 |
| Rattus norvegicus (Norway rat) | Wnk4 | NP_783169.1 |
| Danio rerio (zebrafish) | LOC557091 | XP_685164.3 |
| Danio rerio (zebrafish) | LOC100329810 | XP_002661200.1 |
| Danio rerio (zebrafish) | LOC100330953 | XP_002663933.1 |
| ID | Name | Evidence |
| GO:0006468 | protein phosphorylation | ISS |
| GO:0006811 | ion transport | ISS |
| GO:0006821 | chloride transport | IEA |
| GO:0007243 | intracellular protein kinase cascade | ISS |
| GO:0008104 | protein localization | IEA |
| GO:0050794 | regulation of cellular process | ISS |
Component
| ID | Name | Evidence |
| GO:0005737 | cytoplasm | IEA |
| GO:0005923 | tight junction | ISS |
| GO:0030054 | cell junction | IEA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0004674 | protein serine/threonine kinase activity | ISS |
| GO:0005524 | ATP binding | ISS |
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