• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000339 Homo sapiens solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001126107 Homo sapiens solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_001126108 Homo sapiens solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005256119 PREDICTED: Homo sapiens solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

*Business Day

Related Services

Gene Symbol SLC12A3
Entrez Gene ID 6559
Full Name solute carrier family 12 (sodium/chloride transporter), member 3
Synonyms NCC, NCCT, TSC
General protein information
Preferred Names
solute carrier family 12 member 3
Names
solute carrier family 12 member 3
Na-Cl symporter
Na-Cl cotransporter
thiazide-sensitive Na-Cl cotransporter
thiazide-sensitive sodium-chloride cotransporter
NaCl electroneutral thiazide-sensitive cotransporter
solute carrier family 12 (sodium/chloride transporters), member 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16q13

Summary This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600968

Gitelman syndrome, 263800 (3)

mRNA Protein Product Sequence Price Select
NM_000339, 186910314 NP_000330, 186910315 solute carrier family 12 member 3 isoform 1 ORF Sequence $1500.00
NM_001126107, 186910316 NP_001119579, 186910317 solute carrier family 12 member 3 isoform 2 ORF Sequence $1500.00
NM_001126108, 186910318 NP_001119580, 186910319 solute carrier family 12 member 3 isoform 3 ORF Sequence $1500.00
XM_005256119, 530424255 XP_005256176, 530424256 solute carrier family 12 member 3 isoform X1 ORF Sequence $1500.00
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_19315Cation-coupled Chloride cotransporters
REACT_19397Transport of inorganic cations/anions and amino acids/oligopeptides
REACT_15518Transmembrane transport of small molecules
Homo sapiens (human)SLC12A3NP_000330.2
Pan troglodytes (chimpanzee)SLC12A3XP_510983.2
Macaca mulatta (Rhesus monkey)SLC12A3XP_001093467.2
Canis lupus familiaris (dog)SLC12A3XP_005617594.1
Bos taurus (cattle)SLC12A3NP_001193107.1
Mus musculus (house mouse)Slc12a3NP_062288.2
Rattus norvegicus (Norway rat)Slc12a3NP_062218.3
Gallus gallus (chicken)SLC12A3XP_414059.4
Danio rerio (zebrafish)slc12a3NP_001038545.1
Xenopus (Silurana) tropicalis (western clawed frog)slc12a3XP_002937217.2
Process
IDNameEvidence
GO:0006810transportTAS
GO:0006811ion transportTAS
GO:0006814sodium ion transportISS
GO:0006821chloride transportTAS
GO:0035725sodium ion transmembrane transportISS
GO:0055085transmembrane transportTAS
GO:1902476chloride transmembrane transportIEA
GO:1902476chloride transmembrane transportTAS
Component
IDNameEvidence
GO:0005829cytosolIEA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016020membraneTAS
GO:0016324apical plasma membraneIDA
GO:0016324apical plasma membraneISS
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005215transporter activityISS
GO:0005515protein bindingIPI
GO:0015378sodium:chloride symporter activityTAS
GeneCards SLC12A3
UniProt P55017, J3QSS1
Vega OTTHUMG00000133284
MIM 600968
Ensembl ENSG00000070915
HGNC 10912
HPRD 02984

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLC12A3 gene?

The SLC12A3 gene provides instructions for making a protein known as NCC. This protein is a sodium chloride co-transporter, which means that it moves charged atoms (ions) of sodium (Na+) and chlorine (Cl-) across cell membranes.

The NCC protein is essential for normal kidney function. It is part of the mechanism by which kidneys reabsorb salt (sodium chloride or NaCl) from the urine back into the bloodstream. The retention of salt affects the body's fluid levels and helps maintain blood pressure.

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.