Sequence in raw or FASTA format:
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 [
Homo sapiens (human)]
Gene Symbol SLC20A2
Entrez Gene ID
Full Name solute carrier family 20 (phosphate transporter), member 2
Synonyms GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1
General protein information
sodium-dependent phosphate transporter 2
sodium-dependent phosphate transporter 2
gibbon ape leukemia virus receptor 2
murine leukemia virus, amphotropic, receptor for
Gene Type protein-coding
Homo sapiens (human)
Chromosome:8 Map Location:8p11.21
Summary This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
REACT_19118 SLC-mediated transmembrane transport
REACT_19275 Sodium-coupled phosphate cotransporters
REACT_19397 Transport of inorganic cations/anions and amino acids/oligopeptides
REACT_15518 Transmembrane transport of small molecules
Related articles in PubMed Genetics in arterial calcification: lessons learned from rare diseases. Nitschke Y, et al. Trends Cardiovasc Med, 2012 Aug. PMID 23122642. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965. Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis. Wang C, et al. Nat Genet, 2012 Feb 12. PMID 22327515. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473. See all (21) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Mutations in the underlying disease genes ENPP1, ABCC6, NT5E, and SLC20A2, respectively, lead to arterial media calcification.
Title: Genetics in arterial calcification: lessons learned from rare diseases.
Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis.
Title: Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis.
the human PiT2 histidine, H(502), and the human PiT1 glutamate, E(70),--both conserved in eukaryotic PiT family members--are critical for P(i) transport function
Title: Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Analysis of kinetics and substrate specificity of SLC20A2.
Title: Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.
forms assemblies at cell surface
Title: Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration.
Two highly conserved glutamate residues critical for sodium-dependent phosphate transport are revealed by uncoupling transport function from retroviral receptor function.
Title: Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.
the presence of an aspartic acid in either of the PiT family signature sequences is critical for the Na+-dependent P(i) transport function of human PiT2
Title: Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2.
Results describe the characterization of transport mechanisms and determinants critical for sodium-dependent phosphate symport of the PiT family paralogs human PiT1 and PiT2.
Title: Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.
structure activity relationship of deletion mutants of Pit2 retroviral receptor [Pit2]
Title: The central half of Pit2 is not required for its function as a retroviral receptor.
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