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BMPR1B bone morphogenetic protein receptor, type IB [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu11503 NM_001256794 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu12264 NM_001256793 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu11503 NM_001256792 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu11503 NM_001203 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu11503 XM_006714292 PREDICTED: Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu11503C NM_001256794 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 4, mRNA. Customized vector On-demand 7-9 $269.00
OHu12264C NM_001256793 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu11503C NM_001256792 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu11503C NM_001203 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu11503C XM_006714292 PREDICTED: Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol BMPR1B
Entrez Gene ID 658
Full Name bone morphogenetic protein receptor, type IB
Synonyms ALK-6, ALK6, CDw293
General protein information
Preferred Names
bone morphogenetic protein receptor type-1B
Names
bone morphogenetic protein receptor type-1B
BMPR-1B
BMP type-1B receptor
activin receptor-like kinase 6
serine/threonine receptor kinase
NP_001194.1
NP_001243721.1
NP_001243722.1
NP_001243723.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q22-q24

Summary This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
Disorder

MIM: 603248

Brachydactyly, type A2, 112600 (3); Chrondrodysplasia, acromesomelic,

mRNA Protein Product Sequence Price Select
NM_001203, 169790809 NP_001194, 4502431 bone morphogenetic protein receptor type-1B isoform b precursor ORF Sequence $550.00
NM_001256792, 377823722 NP_001243721, 377823723 bone morphogenetic protein receptor type-1B isoform b precursor ORF Sequence $550.00
NM_001256793, 377823724 NP_001243722, 377823725 bone morphogenetic protein receptor type-1B isoform a precursor ORF Sequence $550.00
NM_001256794, 377823730 NP_001243723, 377823731 bone morphogenetic protein receptor type-1B isoform b precursor ORF Sequence $550.00
XM_006714292, 578809322 XP_006714355, 578809323 bone morphogenetic protein receptor type-1B isoform X1 ORF Sequence $550.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
WikiPathways
WP34Ovarian Infertility Genes
WP1425BMP signalling and regulation
Reactome
REACT_12034Signaling by BMP
REACT_111102Signal Transduction
Homo sapiens (human)BMPR1BNP_001243722.1
Pan troglodytes (chimpanzee)BMPR1BXP_517599.3
Macaca mulatta (Rhesus monkey)BMPR1BXP_001103786.2
Canis lupus familiaris (dog)BMPR1BNP_001138623.1
Bos taurus (cattle)BMPR1BNP_001098798.1
Mus musculus (house mouse)Bmpr1bNP_031586.1
Gallus gallus (chicken)BMPR1BNP_990463.1
Danio rerio (zebrafish)bmpr1baNP_571532.1
Drosophila melanogaster (fruit fly)tkvNP_787990.1
Caenorhabditis eleganssma-6NP_495271.1
Xenopus (Silurana) tropicalis (western clawed frog)bmpr1bNP_001072633.1
Process
IDNameEvidence
GO:0001501skeletal system developmentIMP
GO:0001502cartilage condensationNAS
GO:0001550ovarian cumulus expansionISS
GO:0001654eye developmentISS
GO:0002062chondrocyte differentiationIEA
GO:0006468protein phosphorylationIDA
GO:0006954inflammatory responseIEA
GO:0009953dorsal/ventral pattern formationIEA
GO:0023014signal transduction by phosphorylationIEA
GO:0030501positive regulation of bone mineralizationIMP
GO:0030509BMP signaling pathwayIDA
GO:0030509BMP signaling pathwayNAS
GO:0030509BMP signaling pathwayTAS
GO:0031290retinal ganglion cell axon guidanceIEA
GO:0035108limb morphogenesisIMP
GO:0042698ovulation cycleISS
GO:0045597positive regulation of cell differentiationIMP
GO:0045669positive regulation of osteoblast differentiationIMP
GO:0060041retina development in camera-type eyeIEA
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIC
GO:0043235receptor complexTAS
Function
IDNameEvidence
GO:0004674protein serine/threonine kinase activityIDA
GO:0004675transmembrane receptor protein serine/threonine kinase activityIMP
GO:0004675transmembrane receptor protein serine/threonine kinase activityNAS
GO:0004702receptor signaling protein serine/threonine kinase activityIEA
GO:0005025transforming growth factor beta receptor activity, type IIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0046332SMAD bindingIDA
GO:0046872metal ion bindingIEA
GeneCards BMPR1B
UniProt O00238, A8KAE3
Vega OTTHUMG00000130991
MIM 603248
Ensembl ENSG00000138696
HGNC 1077
HPRD 04457

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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