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BMPR1B bone morphogenetic protein receptor, type IB [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001203 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 2, mRNA. ORF Sequence $437.61
Peptide Services
Antibody Services
Protein Services
NM_001256792 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 3, mRNA. ORF Sequence $437.61
Peptide Services
Antibody Services
Protein Services
NM_001256793 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 1, mRNA. ORF Sequence $463.71
Peptide Services
Antibody Services
Protein Services
NM_001256794 Homo sapiens bone morphogenetic protein receptor, type IB (BMPR1B), transcript variant 4, mRNA. ORF Sequence $437.61
Peptide Services
Antibody Services
Protein Services


Gene Symbol BMPR1B
Entrez Gene ID 658
Full Name bone morphogenetic protein receptor, type IB
Synonyms ALK-6, ALK6, CDw293
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q22-q24

Summary This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
Disorder

MIM: 603248

Brachydactyly, type A2, 112600 (3); Chrondrodysplasia, acromesomelic,

mRNA Protein Product Sequence Price Select
NM_001203, 169790809 NP_001194, 4502431 bone morphogenetic protein receptor type-1B isoform b precursor Full Length $2502.00
ORF Sequence $437.61
NM_001256792, 377823722 NP_001243721, 377823723 bone morphogenetic protein receptor type-1B isoform b precursor Full Length $2455.20
ORF Sequence $437.61
NM_001256793, 377823724 NP_001243722, 377823725 bone morphogenetic protein receptor type-1B isoform a precursor Full Length $2428.65
ORF Sequence $463.71
NM_001256794, 377823730 NP_001243723, 377823731 bone morphogenetic protein receptor type-1B isoform b precursor Full Length $2448.00
ORF Sequence $437.61
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04350TGF-beta signaling pathway
WikiPathways
WP34Ovarian Infertility Genes
WP1425BMP signalling and regulation
Reactome
REACT_12034Signaling by BMP
REACT_111102Signal Transduction
Homo sapiens (human)BMPR1BNP_001194.1
Pan troglodytes (chimpanzee)BMPR1BXP_517599.3
Macaca mulatta (Rhesus monkey)BMPR1BXP_001103786.2
Canis lupus familiaris (dog)BMPR1BNP_001138623.1
Bos taurus (cattle)BMPR1BNP_001098798.1
Mus musculus (house mouse)Bmpr1bNP_031586.1
Gallus gallus (chicken)BMPR1BNP_990463.1
Danio rerio (zebrafish)bmpr1baNP_571532.1
GeneCards BMPR1B
PDB 3MDY
UniProt O00238, A8KAE3
MIM 603248
Ensembl ENSG00000138696
HGNC 1077
HPRD 04457

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
bone morphogenetic protein receptor type-1B
Names
bone morphogenetic protein receptor type-1B
BMPR-1B
BMP type-1B receptor
activin receptor-like kinase 6
serine/threonine receptor kinase
NP_001194.1
NP_001243721.1
NP_001243722.1
NP_001243723.1

Interactant

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