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SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003059 Homo sapiens solute carrier family 22 (organic cation/zwitterion transporter), member 4 (SLC22A4), mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006714675 PREDICTED: Homo sapiens solute carrier family 22 (organic cation/zwitterion transporter), member 4 (SLC22A4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol SLC22A4
Entrez Gene ID 6583
Full Name solute carrier family 22 (organic cation/zwitterion transporter), member 4
Synonyms OCTN1
General protein information
Preferred Names
solute carrier family 22 member 4
Names
solute carrier family 22 member 4
ET transporter
ergothioneine transporter
integral membrane transport protein
organic cation/carnitine transporter 1
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31.1

Summary Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604190

{Rheumatoid arthritis, susceptibility to}, 180300 (3)

mRNA Protein Product Sequence Price Select
NM_003059, 24497489 NP_003050, 24497490 solute carrier family 22 member 4 ORF Sequence $550.00
XM_006714675, 578810506 XP_006714738, 578810507 solute carrier family 22 member 4 isoform X1 ORF Sequence $400.00
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_19305Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
REACT_15518Transmembrane transport of small molecules
REACT_22345Organic cation/anion/zwitterion transport
REACT_22357Organic cation transport
Homo sapiens (human)SLC22A4NP_003050.2
Pan troglodytes (chimpanzee)SLC22A4XP_001163062.1
Macaca mulatta (Rhesus monkey)LOC710179XP_002804554.1
Canis lupus familiaris (dog)SLC22A4XP_005626572.1
Bos taurus (cattle)SLC22A4NP_001193918.1
Mus musculus (house mouse)Slc22a4NP_062661.1
Rattus norvegicus (Norway rat)Slc22a4NP_071606.1
Gallus gallus (chicken)SLC22A4NP_001139603.1
Danio rerio (zebrafish)LOC100000685XP_005170394.1
Process
IDNameEvidence
GO:0006641triglyceride metabolic processIEA
GO:0006814sodium ion transportIEA
GO:0007589body fluid secretionTAS
GO:0009437carnitine metabolic processIEA
GO:0015695organic cation transportTAS
GO:0015697quaternary ammonium group transportIDA
GO:0015879carnitine transportIDA
GO:0055085transmembrane transportTAS
GO:1902603carnitine transmembrane transportIDA
GO:1902603carnitine transmembrane transportIEA
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005886plasma membraneIC
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016324apical plasma membraneIDA
Function
IDNameEvidence
GO:0000166nucleotide bindingTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008513secondary active organic cation transmembrane transporter activityTAS
GO:0015226carnitine transmembrane transporter activityIDA
GO:0015293symporter activityIEA
GO:0015491cation:cation antiporter activityIDA
GO:0015651quaternary ammonium group transmembrane transporter activityIDA
GO:0030165PDZ domain bindingIPI
GeneCards SLC22A4
UniProt Q9H015
Vega OTTHUMG00000059648
MIM 604190
Ensembl ENSG00000197208
HGNC 10968
HPRD 09171

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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