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SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003060 Homo sapiens solute carrier family 22 (organic cation/carnitine transporter), member 5 (SLC22A5), mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005272055 PREDICTED: Homo sapiens solute carrier family 22 (organic cation/carnitine transporter), member 5 (SLC22A5), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006714676 PREDICTED: Homo sapiens solute carrier family 22 (organic cation/carnitine transporter), member 5 (SLC22A5), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol SLC22A5
Entrez Gene ID 6584
Full Name solute carrier family 22 (organic cation/carnitine transporter), member 5
General protein information
Preferred Names
solute carrier family 22 member 5
solute carrier family 22 member 5
organic cation/carnitine transporter 2
high-affinity sodium dependent carnitine cotransporter
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. [provided by RefSeq, Jul 2008].

MIM: 603377

Carnitine deficiency, systemic primary, 212140 (3)

mRNA Protein Product Sequence Price Select
NM_003060, 166064030 NP_003051, 4507005 solute carrier family 22 member 5 ORF Sequence $550.00
XM_005272055, 578810508 XP_005272112, 530380094 solute carrier family 22 member 5 isoform X1 ORF Sequence $700.00
XM_006714676, 578810509 XP_006714739, 578810510 solute carrier family 22 member 5 isoform X2 ORF Sequence $400.00
REACT_19118SLC-mediated transmembrane transport
REACT_19305Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
REACT_15518Transmembrane transport of small molecules
REACT_22345Organic cation/anion/zwitterion transport
REACT_22357Organic cation transport
Homo sapiens (human)SLC22A5NP_003051.1
Pan troglodytes (chimpanzee)SLC22A5XP_003310855.1
Macaca mulatta (Rhesus monkey)SLC22A5XP_001103789.1
Canis lupus familiaris (dog)SLC22A5XP_860734.1
Bos taurus (cattle)SLC22A5NP_001039967.1
Mus musculus (house mouse)Slc22a5NP_035526.1
Rattus norvegicus (Norway rat)Slc22a5NP_062142.1
Danio rerio (zebrafish)slc22a4NP_957143.1
Arabidopsis thaliana (thale cress)2-OctNP_178054.1
Arabidopsis thaliana (thale cress)3-OctNP_173089.1
Xenopus (Silurana) tropicalis (western clawed frog)slc22a4NP_989323.1
Xenopus (Silurana) tropicalis (western clawed frog)slc22a5XP_002934410.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC101731319XP_004920385.1
GO:0006814sodium ion transportIEA
GO:0006855drug transmembrane transportIC
GO:0015697quaternary ammonium group transportIDA
GO:0015879carnitine transportIDA
GO:0015879carnitine transportIMP
GO:0015893drug transportIC
GO:0042891antibiotic transportIEA
GO:0052106quorum sensing involved in interaction with hostIMP
GO:0055085transmembrane transportTAS
GO:0060731positive regulation of intestinal epithelial structure maintenanceIMP
GO:0070715sodium-dependent organic cation transportIDA
GO:1902603carnitine transmembrane transportIDA
GO:1902603carnitine transmembrane transportIEA
GO:1902603carnitine transmembrane transportIMP
GO:0005886plasma membraneIC
GO:0005886plasma membraneTAS
GO:0016021integral component of membraneIEA
GO:0016323basolateral plasma membraneIEA
GO:0016324apical plasma membraneIDA
GO:0031526brush border membraneIDA
GO:0031526brush border membraneISS
GO:0070062extracellular vesicular exosomeIDA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0015226carnitine transmembrane transporter activityIDA
GO:0015226carnitine transmembrane transporter activityIMP
GO:0015238drug transmembrane transporter activityIC
GO:0015293symporter activityIEA
GO:0015651quaternary ammonium group transmembrane transporter activityIDA
GO:0030165PDZ domain bindingIPI
GO:0042895antibiotic transporter activityIEA
GeneCards SLC22A5
UniProt O76082
Vega OTTHUMG00000059634
MIM 603377
Ensembl ENSG00000197375
HGNC 10969
HPRD 04539

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLC22A5 gene?

The SLC22A5 gene provides instructions for making a protein called OCTN2 that is found in the heart, liver, muscles, kidneys, and other tissues. This protein is positioned within the cell membrane, where it transports a substance known as carnitine into the cell. Carnitine is mainly obtained from the diet and is needed to bring certain types of fats (fatty acids) into mitochondria, the energy-producing centers within cells. Fatty acids are a major source of energy for the heart and muscles. During periods without food (fasting), fatty acids are also an important energy source for the liver and other tissues.


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