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SNAI2 snail family zinc finger 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003068 Homo sapiens snail family zinc finger 2 (SNAI2), mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10

*Business Day

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Gene Symbol SNAI2
Entrez Gene ID 6591
Full Name snail family zinc finger 2
General protein information
Preferred Names
zinc finger protein SNAI2
zinc finger protein SNAI2
snail homolog 2
protein snail homolog 2
neural crest transcription factor SLUG
slug (chicken homolog), zinc finger protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].

MIM: 602150

Waardenburg syndrome, type 2D, 608890 (3); Piebaldism, 172800 (3)

mRNA Protein Product Sequence Price Select
NM_003068, 324072669 NP_003059, 11276067 zinc finger protein SNAI2 ORF Sequence $199.00
hsa04520Adherens junction
hsa04390Hippo signaling pathway
WP2064Neural Crest Differentiation
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Homo sapiens (human)SNAI2NP_003059.1
Pan troglodytes (chimpanzee)SNAI2XP_003951309.1
Macaca mulatta (Rhesus monkey)SNAI2XP_001101435.1
Canis lupus familiaris (dog)SNAI2NP_001091450.1
Bos taurus (cattle)SNAI2NP_001029710.1
Mus musculus (house mouse)Snai2NP_035545.1
Rattus norvegicus (Norway rat)Snai2NP_037167.1
Gallus gallus (chicken)SNAI2XP_419196.1
Danio rerio (zebrafish)snai2NP_001008581.1
Caenorhabditis elegansK02D7.2NP_499902.2
Xenopus (Silurana) tropicalis (western clawed frog)snai2NP_989424.1
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMP
GO:0001649osteoblast differentiationIEP
GO:0001837epithelial to mesenchymal transitionIMP
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationISS
GO:0003273cell migration involved in endocardial cushion formationISS
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0006933negative regulation of cell adhesion involved in substrate-bound cell migrationIEA
GO:0007219Notch signaling pathwayIMP
GO:0007605sensory perception of soundIMP
GO:0009790embryo developmentIEA
GO:0010839negative regulation of keratinocyte proliferationIDA
GO:0010957negative regulation of vitamin D biosynthetic processIDA
GO:0014032neural crest cell developmentIMP
GO:0030335positive regulation of cell migrationIMP
GO:0032331negative regulation of chondrocyte differentiationIMP
GO:0032642regulation of chemokine productionIMP
GO:0033629negative regulation of cell adhesion mediated by integrinIC
GO:0035066positive regulation of histone acetylationIEA
GO:0035414negative regulation of catenin import into nucleusIDA
GO:0035921desmosome disassemblyIMP
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediatorIMP
GO:0044344cellular response to fibroblast growth factor stimulusIEA
GO:0045600positive regulation of fat cell differentiationIEA
GO:0045667regulation of osteoblast differentiationIMP
GO:0050872white fat cell differentiationIEA
GO:0060021palate developmentIEA
GO:0060070canonical Wnt signaling pathwayIMP
GO:0060429epithelium developmentISS
GO:0060536cartilage morphogenesisIEA
GO:0060693regulation of branching involved in salivary gland morphogenesisIEA
GO:0070563negative regulation of vitamin D receptor signaling pathwayIDA
GO:0071364cellular response to epidermal growth factor stimulusIDA
GO:0071479cellular response to ionizing radiationIEA
GO:0090090negative regulation of canonical Wnt signaling pathwayIDA
GO:0090090negative regulation of canonical Wnt signaling pathwayIMP
GO:1900387negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoterIMP
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageIMP
GO:2000647negative regulation of stem cell proliferationIEA
GO:2000810regulation of tight junction assemblyIMP
GO:2000811negative regulation of anoikisIMP
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandISS
GO:0000790nuclear chromatinIDA
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDA
GO:0003682chromatin bindingIEA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIDA
GO:0046872metal ion bindingIEA
GeneCards SNAI2
UniProt O43623
Vega OTTHUMG00000149912
MIM 602150
Ensembl ENSG00000019549
HGNC 11094
HPRD 03689

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SNAI2 gene?

The SNAI2 gene (often called SLUG) provides the instructions for making a protein called snail 2. Snail 2 belongs to the snail protein family, which plays a role in the formation of tissues during embryonic development. The snail 2 protein is also found in most adult tissues, so it probably helps maintain the normal function of cells after birth. To carry out these roles, snail 2 attaches to critical regions of DNA and helps control the activity of particular genes. On the basis of this action, the protein is called a transcription factor.

Research indicates that the snail 2 protein is required during embryonic growth for the development of cells called neural crest cells. Neural crest cells migrate from the developing spinal cord to specific regions in the embryo and give rise to many tissues and cell types such as limb muscles, bones in the face and skull (craniofacial bones), some nerve tissue, and pigment-producing cells called melanocytes. Melanocytes produce the pigment melanin, which contributes to hair, eye, and skin color. Melanocytes are also found in certain regions of the brain and inner ear. The snail 2 protein probably plays a role in the formation and survival of melanocytes.


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