• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


SNAI2 snail family zinc finger 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22833 NM_003068 Homo sapiens snail family zinc finger 2 (SNAI2), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu22833C NM_003068 Homo sapiens snail family zinc finger 2 (SNAI2), mRNA. Customized vector In-stock 5-7 $149.00

*Business Day

Related Services

Gene Symbol SNAI2
Entrez Gene ID 6591
Full Name snail family zinc finger 2
Synonyms SLUG, SLUGH1, SNAIL2, WS2D
General protein information
Preferred Names
zinc finger protein SNAI2
Names
zinc finger protein SNAI2
snail homolog 2
protein snail homolog 2
neural crest transcription factor SLUG
slug (chicken homolog), zinc finger protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q11

Summary This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602150

Waardenburg syndrome, type 2D, 608890 (3); Piebaldism, 172800 (3)

mRNA Protein Product Sequence Price Select
NM_003068, 324072669 NP_003059, 11276067 zinc finger protein SNAI2 ORF Sequence $199.00
KEGG
hsa04520Adherens junction
hsa04390Hippo signaling pathway
WikiPathways
WP2064Neural Crest Differentiation
Pathway Interaction Database
p53downstreampathwayDirect p53 effectors
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Homo sapiens (human)SNAI2NP_003059.1
Pan troglodytes (chimpanzee)SNAI2XP_003951309.1
Macaca mulatta (Rhesus monkey)SNAI2XP_001101435.1
Canis lupus familiaris (dog)SNAI2NP_001091450.1
Bos taurus (cattle)SNAI2NP_001029710.1
Mus musculus (house mouse)Snai2NP_035545.1
Rattus norvegicus (Norway rat)Snai2NP_037167.1
Gallus gallus (chicken)SNAI2XP_419196.1
Danio rerio (zebrafish)snai2NP_001008581.1
Caenorhabditis elegansK02D7.2NP_499902.2
Xenopus (Silurana) tropicalis (western clawed frog)snai2NP_989424.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0000122negative regulation of transcription from RNA polymerase II promoterIMP
GO:0001649osteoblast differentiationIEP
GO:0001837epithelial to mesenchymal transitionIMP
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formationISS
GO:0003273cell migration involved in endocardial cushion formationISS
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0006933negative regulation of cell adhesion involved in substrate-bound cell migrationIEA
GO:0007219Notch signaling pathwayIMP
GO:0007605sensory perception of soundIMP
GO:0009790embryo developmentIEA
GO:0010839negative regulation of keratinocyte proliferationIDA
GO:0010957negative regulation of vitamin D biosynthetic processIDA
GO:0014032neural crest cell developmentIMP
GO:0030335positive regulation of cell migrationIMP
GO:0032331negative regulation of chondrocyte differentiationIMP
GO:0032642regulation of chemokine productionIMP
GO:0033629negative regulation of cell adhesion mediated by integrinIC
GO:0035066positive regulation of histone acetylationIEA
GO:0035414negative regulation of catenin import into nucleusIDA
GO:0035921desmosome disassemblyIMP
GO:0043473pigmentationIMP
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediatorIMP
GO:0044344cellular response to fibroblast growth factor stimulusIEA
GO:0045600positive regulation of fat cell differentiationIEA
GO:0045667regulation of osteoblast differentiationIMP
GO:0050872white fat cell differentiationIEA
GO:0060021palate developmentIEA
GO:0060070canonical Wnt signaling pathwayIMP
GO:0060429epithelium developmentISS
GO:0060536cartilage morphogenesisIEA
GO:0060693regulation of branching involved in salivary gland morphogenesisIEA
GO:0070563negative regulation of vitamin D receptor signaling pathwayIDA
GO:0071364cellular response to epidermal growth factor stimulusIDA
GO:0071479cellular response to ionizing radiationIEA
GO:0090090negative regulation of canonical Wnt signaling pathwayIDA
GO:0090090negative regulation of canonical Wnt signaling pathwayIMP
GO:1900387negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoterIMP
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damageIMP
GO:2000647negative regulation of stem cell proliferationIEA
GO:2000810regulation of tight junction assemblyIMP
GO:2000811negative regulation of anoikisIMP
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandISS
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDA
GO:0003682chromatin bindingIEA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEA
GO:0043565sequence-specific DNA bindingIDA
GO:0046872metal ion bindingIEA
GeneCards SNAI2
UniProt O43623
Vega OTTHUMG00000149912
MIM 602150
Ensembl ENSG00000019549
HGNC 11094
HPRD 03689

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.