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SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001289396 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001289397 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001289398 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001289399 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001289400 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_003070 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_139045 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol SMARCA2
Entrez Gene ID 6595
Full Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a
General protein information
Preferred Names
probable global transcription activator SNF2L2
Names
probable global transcription activator SNF2L2
BAF190B
SNF2-alpha
protein brahma homolog
SNF2/SWI2-like protein 2
BRG1-associated factor 190B
ATP-dependent helicase SMARCA2
sucrose nonfermenting 2-like protein 2
global transcription activator homologous sequence
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p22.3

Summary The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014].
Disorder

MIM: 600014

mRNA Protein Product Sequence Price Select
NM_001289396, 574957242 NP_001276325, 574957243 probable global transcription activator SNF2L2 isoform a ORF Sequence $2500.00
NM_001289397, 574957244 NP_001276326, 574957245 probable global transcription activator SNF2L2 isoform c ORF Sequence $2500.00
NM_001289398, 574957246 NP_001276327, 574957247 probable global transcription activator SNF2L2 isoform d ORF Sequence $250.00
NM_001289399, 574957248 NP_001276328, 574957249 probable global transcription activator SNF2L2 isoform e precursor ORF Sequence $300.00
NM_001289400, 574957250 NP_001276329, 574957251 probable global transcription activator SNF2L2 isoform f precursor ORF Sequence $300.00
NM_003070, 574957238 NP_003061, 48255900 probable global transcription activator SNF2L2 isoform a ORF Sequence $2500.00
NM_139045, 574957241 NP_620614, 48255898 probable global transcription activator SNF2L2 isoform b ORF Sequence $2500.00
WikiPathways
WP2446RB in Cancer
Pathway Interaction Database
e2f_pathwayE2F transcription factor network
cmyb_pathwayC-MYB transcription factor network
ar_tf_pathwayRegulation of Androgen receptor activity
Homo sapiens (human)SMARCA2NP_001276325.1
Pan troglodytes (chimpanzee)SMARCA2XP_003951484.1
Canis lupus familiaris (dog)SMARCA2XP_850159.1
Bos taurus (cattle)SMARCA2NP_001092585.1
Mus musculus (house mouse)Smarca2NP_035546.2
Rattus norvegicus (Norway rat)Smarca2NP_001004446.1
Gallus gallus (chicken)SMARCA2NP_990470.1
Danio rerio (zebrafish)smarca2NP_001038240.1
Drosophila melanogaster (fruit fly)brmNP_730089.1
Caenorhabditis elegansswsn-4NP_502082.1
Arabidopsis thaliana (thale cress)AT5G19310NP_197432.2
Arabidopsis thaliana (thale cress)ATCHR12NP_187252.2
Xenopus (Silurana) tropicalis (western clawed frog)smarca2XP_004910846.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS
GO:0006200ATP catabolic processTAS
GO:0006338chromatin remodelingTAS
GO:0006351transcription, DNA-templatedIEA
GO:0006355regulation of transcription, DNA-templatedTAS
GO:0006357regulation of transcription from RNA polymerase II promoterTAS
GO:0007399nervous system developmentIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0030308negative regulation of cell growthIMP
GO:0035887aortic smooth muscle cell differentiationIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterTAS
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005730nucleolusIDA
GO:0016514SWI/SNF complexIDA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0045111intermediate filament cytoskeletonIDA
GO:0071564npBAF complexISS
GO:0071565nBAF complexISS
Function
IDNameEvidence
GO:0001105RNA polymerase II transcription coactivator activityIDA
GO:0003713transcription coactivator activityTAS
GO:0004386helicase activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008094DNA-dependent ATPase activityTAS
GO:0042393histone bindingIEA
GO:0044212transcription regulatory region DNA bindingIDA
GeneCards SMARCA2
UniProt B4DNT1, B1ALF6, Q8N9Q1, Q56A76, B4DSC8, P51531
Vega OTTHUMG00000019445
MIM 600014
Ensembl ENSG00000080503
HGNC 11098
HPRD 02483

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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