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SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu24945 NM_003079 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu24945C NM_003079 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol SMARCE1
Entrez Gene ID 6605
Full Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms BAF57
General protein information
Preferred Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
BRG1-associated factor 57
chromatin remodeling complex BRG1-associated factor 57
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21.2

Summary The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603111

mRNA Protein Product Sequence Price Select
NM_003079, 45827732 NP_003070, 21264355 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 ORF Sequence $269.00
WikiPathways
WP138Androgen receptor signaling pathway
WP231TNF-alpha/NF-kB Signaling Pathway
Pathway Interaction Database
ar_tf_pathwayRegulation of Androgen receptor activity
Homo sapiens (human)SMARCE1NP_003070.3
Pan troglodytes (chimpanzee)SMARCE1XP_511478.2
Macaca mulatta (Rhesus monkey)SMARCE1XP_001099623.2
Canis lupus familiaris (dog)SMARCE1XP_851010.1
Bos taurus (cattle)SMARCE1NP_001092586.1
Mus musculus (house mouse)Smarce1NP_065643.1
Rattus norvegicus (Norway rat)Smarce1NP_001020164.1
Gallus gallus (chicken)SMARCE1NP_001006335.2
Danio rerio (zebrafish)smarce1NP_958455.2
Caenorhabditis elegansswsn-3NP_497613.2
Xenopus (Silurana) tropicalis (western clawed frog)smarce1NP_001005436.1
Process
IDNameEvidence
GO:0006337nucleosome disassemblyIDA
GO:0006338chromatin remodelingIDA
GO:0006357regulation of transcription from RNA polymerase II promoterNAS
GO:0007399nervous system developmentIEA
GO:0008152metabolic processIDA
GO:0043044ATP-dependent chromatin remodelingIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
Component
IDNameEvidence
GO:0000228nuclear chromosomeTAS
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0016514SWI/SNF complexIDA
GO:0017053transcriptional repressor complexIPI
GO:0043234protein complexIDA
GO:0071564npBAF complexISS
GO:0071565nBAF complexISS
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDA
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDA
GO:0003682chromatin bindingTAS
GO:0003713transcription coactivator activityNAS
GO:0003723RNA bindingIEA
GO:0005515protein bindingIPI
GO:0008080N-acetyltransferase activityIDA
GO:0016922ligand-dependent nuclear receptor bindingIPI
GO:0031492nucleosomal DNA bindingIDA
GO:0047485protein N-terminus bindingIPI
GeneCards SMARCE1
UniProt Q969G3
Vega OTTHUMG00000133367
MIM 603111
Ensembl ENSG00000073584
HGNC 11109
HPRD 04382

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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