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SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003079 Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (SMARCE1), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol SMARCE1
Entrez Gene ID 6605
Full Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms BAF57
General protein information
Preferred Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
BRG1-associated factor 57
chromatin remodeling complex BRG1-associated factor 57
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21.2

Summary The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603111

mRNA Protein Product Sequence Price Select
NM_003079, 45827732 NP_003070, 21264355 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 ORF Sequence $269.00
WikiPathways
WP138Androgen receptor signaling pathway
WP231TNF-alpha/NF-kB Signaling Pathway
Pathway Interaction Database
ar_tf_pathwayRegulation of Androgen receptor activity
Homo sapiens (human)SMARCE1NP_003070.3
Pan troglodytes (chimpanzee)SMARCE1XP_511478.2
Macaca mulatta (Rhesus monkey)SMARCE1XP_001099623.2
Canis lupus familiaris (dog)SMARCE1XP_851010.1
Bos taurus (cattle)SMARCE1NP_001092586.1
Mus musculus (house mouse)Smarce1NP_065643.1
Rattus norvegicus (Norway rat)Smarce1NP_001020164.1
Gallus gallus (chicken)SMARCE1NP_001006335.2
Danio rerio (zebrafish)smarce1NP_958455.2
Caenorhabditis elegansswsn-3NP_497613.2
Xenopus (Silurana) tropicalis (western clawed frog)smarce1NP_001005436.1
Process
IDNameEvidence
GO:0006337nucleosome disassemblyIDA
GO:0006338chromatin remodelingIDA
GO:0006357regulation of transcription from RNA polymerase II promoterNAS
GO:0007399nervous system developmentIEA
GO:0008152metabolic processIDA
GO:0043044ATP-dependent chromatin remodelingIDA
GO:0045892negative regulation of transcription, DNA-templatedIDA
Component
IDNameEvidence
GO:0000228nuclear chromosomeTAS
GO:0000790nuclear chromatinIDA
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0016514SWI/SNF complexIDA
GO:0017053transcriptional repressor complexIPI
GO:0043234protein complexIDA
GO:0071564npBAF complexISS
GO:0071565nBAF complexISS
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDA
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDA
GO:0003682chromatin bindingTAS
GO:0003713transcription coactivator activityNAS
GO:0003723RNA bindingIEA
GO:0005515protein bindingIPI
GO:0008080N-acetyltransferase activityIDA
GO:0016922ligand-dependent nuclear receptor bindingIPI
GO:0031492nucleosomal DNA bindingIDA
GO:0047485protein N-terminus bindingIPI
GeneCards SMARCE1
UniProt Q969G3
Vega OTTHUMG00000133367
MIM 603111
Ensembl ENSG00000073584
HGNC 11109
HPRD 04382

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SMARCE1 gene?

The SMARCE1 gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.

Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells.

The role of the SMARCE1 protein within the SWI/SNF complex is not completely understood.

Interactant

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