Sequence in raw or FASTA format:
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 [Homo sapiens (human)]
|Entrez Gene ID||6605|
|Full Name||SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008].|
|WP138||Androgen receptor signaling pathway|
|WP231||TNF-alpha/NF-kB Signaling Pathway|
|ar_tf_pathway||Regulation of Androgen receptor activity|
|Homo sapiens (human)||SMARCE1||NP_003070.3|
|Pan troglodytes (chimpanzee)||SMARCE1||XP_511478.2|
|Macaca mulatta (Rhesus monkey)||SMARCE1||XP_001099623.2|
|Canis lupus familiaris (dog)||SMARCE1||XP_851010.1|
|Bos taurus (cattle)||SMARCE1||NP_001092586.1|
|Mus musculus (house mouse)||Smarce1||NP_065643.1|
|Rattus norvegicus (Norway rat)||Smarce1||NP_001020164.1|
|Gallus gallus (chicken)||SMARCE1||NP_001006335.2|
|Danio rerio (zebrafish)||smarce1||NP_958455.2|
|Xenopus (Silurana) tropicalis (western clawed frog)||smarce1||NP_001005436.1|
|GO:0006357||regulation of transcription from RNA polymerase II promoter||NAS|
|GO:0007399||nervous system development||IEA|
|GO:0043044||ATP-dependent chromatin remodeling||IDA|
|GO:0045892||negative regulation of transcription, DNA-templated||IDA|
|GO:0017053||transcriptional repressor complex||IPI|
|GO:0000978||RNA polymerase II core promoter proximal region sequence-specific DNA binding||IDA|
|GO:0000980||RNA polymerase II distal enhancer sequence-specific DNA binding||IDA|
|GO:0003713||transcription coactivator activity||NAS|
|GO:0016922||ligand-dependent nuclear receptor binding||IPI|
|GO:0031492||nucleosomal DNA binding||IDA|
|GO:0047485||protein N-terminus binding||IPI|
What is the normal function of the SMARCE1 gene?
The SMARCE1 gene provides instructions for making a protein that forms one piece (subunit) of several different SWI/SNF protein complexes. SWI/SNF complexes regulate gene activity (expression) by a process known as chromatin remodeling. Chromatin is the network of DNA and protein that packages DNA into chromosomes. The structure of chromatin can be changed (remodeled) to alter how tightly DNA is packaged. Chromatin remodeling is one way gene expression is regulated during development; when DNA is tightly packed, gene expression is lower than when DNA is loosely packed.
Through their ability to regulate gene activity, SWI/SNF complexes are involved in many processes, including repairing damaged DNA; copying (replicating) DNA; and controlling the growth, division, and maturation (differentiation) of cells.
The role of the SMARCE1 protein within the SWI/SNF complex is not completely understood.
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