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SNCA synuclein, alpha (non A4 component of amyloid precursor) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000345 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services
NM_001146054 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 2, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services
NM_001146055 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 3, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services
NM_007308 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services


Gene Symbol SNCA
Entrez Gene ID 6622
Full Name synuclein, alpha (non A4 component of amyloid precursor)
Synonyms MGC110988, NACP, PARK1, PARK4, PD1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].
Disorder

MIM: 163890

Parkinson disease 4, 605543 (3); Dementia, Lewy body, 127750 (3);

mRNA Protein Product Sequence Price Select
NM_000345, 225690599 NP_000336, 4507109 alpha-synuclein isoform NACP140 Full Length $1125.25
ORF Sequence $159.00
NM_001146054, 225690601 NP_001139526, 225690602 alpha-synuclein isoform NACP140 Full Length $1123.85
ORF Sequence $159.00
NM_001146055, 225690603 NP_001139527, 225690604 alpha-synuclein isoform NACP140 Full Length $1057.70
ORF Sequence $159.00
NM_007308, 225690600 NP_009292, 6806898 alpha-synuclein isoform NACP112 Full Length $1094.45
ORF Sequence $159.00
KEGG
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
WikiPathways
WP2359Parkin-Ubiquitin Proteasomal System pathway
WP2059Alzheimers Disease
WP2371Parkinsons Disease Pathway
WP437EGFR1 Signaling Pathway
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
Reactome
REACT_116125Disease
REACT_75925Amyloids
Homo sapiens (human)SNCANP_000336.1
Pan troglodytes (chimpanzee)SNCANP_001009158.1
Canis lupus familiaris (dog)SNCAXP_535656.1
Bos taurus (cattle)SNCANP_001029213.1
Mus musculus (house mouse)SncaNP_001035916.1
Rattus norvegicus (Norway rat)SncaNP_062042.1
Gallus gallus (chicken)SNCANP_990004.1
GeneCards SNCA
PDB 3Q28, 1XQ8, 3Q29, 2JN5, 3Q26, 2X6M, 2KKW, 3Q25, 3Q27
UniProt H6UYS5, P37840
MIM 163890
Ensembl ENSG00000145335
HGNC 11138
HPRD 01227

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant

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