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SNCA synuclein, alpha (non A4 component of amyloid precursor) [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_000345 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA. Full Length $1125.25
ORF Sequence $159.00
NM_007308 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA. Full Length $1094.45
ORF Sequence $159.00
NM_001146054 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 2, mRNA. Full Length $1123.85
ORF Sequence $159.00
NM_001146055 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 3, mRNA. Full Length $1057.70
ORF Sequence $159.00


Gene Symbol SNCA
Entrez Gene ID 6622
Full Name synuclein, alpha (non A4 component of amyloid precursor)
Synonyms MGC110988, NACP, PARK1, PARK4, PD1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21
Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq].
Disorder

MIM: 163890

Parkinson disease 4, 605543 (3); Dementia, Lewy body, 127750 (3);
mRNA NM_000345, 225690599
Protein NP_000336, 4507109
Product alpha-synuclein isoform NACP140
RefSeq Status REVIEWED
mRNA NM_007308, 225690600
Protein NP_009292, 6806898
Product alpha-synuclein isoform NACP112
RefSeq Status REVIEWED
mRNA NM_001146054, 225690601
Protein NP_001139526, 225690602
Product alpha-synuclein isoform NACP140
RefSeq Status REVIEWED
mRNA NM_001146055, 225690603
Protein NP_001139527, 225690604
Product alpha-synuclein isoform NACP140
RefSeq Status REVIEWED
KEGG
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
WikiPathways
WP437EGFR1 Signaling Pathway
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
Homo sapiens (human)SNCANP_000336.1
Pan troglodytes (chimpanzee)SNCAXP_517341.2
Canis lupus familiaris (dog)SNCAXP_535656.1
Bos taurus (cattle)SNCANP_001029213.1
Mus musculus (house mouse)SncaNP_033247.1
Rattus norvegicus (Norway rat)SncaNP_062042.1
Gallus gallus (chicken)SNCANP_990004.1
Process
IDNameEvidence
GO:0001774microglial cell activationIEA
GO:0001921positive regulation of receptor recyclingIDA
GO:0001956positive regulation of neurotransmitter secretionIEA
GO:0001963synaptic transmission, dopaminergicIEA
GO:0006631fatty acid metabolic processIEA
GO:0006638neutral lipid metabolic processIEA
GO:0006644phospholipid metabolic processIEA
GO:0006916anti-apoptosisIMP
GO:0006919activation of caspase activityIDA
GO:0007006mitochondrial membrane organizationIEA
GO:0008219cell deathIEA
GO:0008344adult locomotory behaviorIEA
GO:0010040response to iron(II) ionIDA
GO:0010517regulation of phospholipase activityIDA
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathwayIDA
GO:0014048regulation of glutamate secretionIEA
GO:0014059regulation of dopamine secretionIEA
GO:0031115negative regulation of microtubule polymerizationIDA
GO:0031623receptor internalizationIDA
GO:0032026response to magnesium ionIDA
GO:0032410negative regulation of transporter activityIDA
GO:0032496response to lipopolysaccharideIDA
GO:0032769negative regulation of monooxygenase activityIDA
GO:0033138positive regulation of peptidyl-serine phosphorylationISS
GO:0034341response to interferon-gammaIDA
GO:0034599cellular response to oxidative stressIEA
GO:0035067negative regulation of histone acetylationIDA
GO:0040012regulation of locomotionIEA
GO:0042416dopamine biosynthetic processIEA
GO:0042493response to drugIEA
GO:0042775mitochondrial ATP synthesis coupled electron transportIEA
GO:0043030regulation of macrophage activationIEA
GO:0043154negative regulation of caspase activityIDA
GO:0043154negative regulation of caspase activityIMP
GO:0043524negative regulation of neuron apoptosisIEA
GO:0045807positive regulation of endocytosisIDA
GO:0045920negative regulation of exocytosisIMP
GO:0048169regulation of long-term neuronal synaptic plasticityIEA
GO:0048488synaptic vesicle endocytosisISS
GO:0050812regulation of acyl-CoA biosynthetic processIEA
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIDA
GO:0051585negative regulation of dopamine uptakeIDA
GO:0051612negative regulation of serotonin uptakeIDA
GO:0051622negative regulation of norepinephrine uptakeIDA
GO:0055074calcium ion homeostasisIDA
GO:0060079regulation of excitatory postsynaptic membrane potentialIEA
GO:0060291long-term synaptic potentiationIEA
GO:0060732positive regulation of inositol phosphate biosynthetic processIDA
GO:0070495negative regulation of thrombin receptor signaling pathwayIDA
GO:0070555response to interleukin-1IDA
GO:0071902positive regulation of protein serine/threonine kinase activityIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005829cytosolIDA
GO:0005886plasma membraneIDA
GO:0005938cell cortexIDA
GO:0015629actin cytoskeletonIDA
GO:0019717synaptosomeIEA
GO:0030054cell junctionIEA
GO:0030424axonIDA
GO:0030426growth coneIDA
GO:0031092platelet alpha granule membraneIDA
GO:0043205fibrilIDA
GO:0045202synapseIEA
Function
IDNameEvidence
GO:0000287magnesium ion bindingIDA
GO:0005504fatty acid bindingIDA
GO:0005509calcium ion bindingIDA
GO:0005515protein bindingIPI
GO:0008198ferrous iron bindingIDA
GO:0008270zinc ion bindingIDA
GO:0019894kinesin bindingIPI
GO:0030544Hsp70 protein bindingIPI
GO:0042393histone bindingIDA
GO:0042802identical protein bindingIEA
GO:0043014alpha-tubulin bindingIPI
GO:0043027caspase inhibitor activityIDA
GO:0045502dynein bindingIPI
GO:0048156tau protein bindingIDA
GO:0050544arachidonic acid bindingIEA
GO:0051219phosphoprotein bindingIDA
GO:0060961phospholipase D inhibitor activityIDA
GeneCards SNCA
PDB 2X6M, 1XQ8, 2KKW, 2JN5
UniProt P37840
MIM 163890
Ensembl ENSG00000145335
HGNC 11138
HPRD 01227

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