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SNCA synuclein, alpha (non A4 component of amyloid precursor) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000345 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001146054 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001146055 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_007308 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Related Services

Gene Symbol SNCA
Entrez Gene ID 6622
Full Name synuclein, alpha (non A4 component of amyloid precursor)
Synonyms MGC110988, NACP, PARK1, PARK4, PD1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].
Disorder

MIM: 163890

Parkinson disease 4, 605543 (3); Dementia, Lewy body, 127750 (3);

mRNA Protein Product Sequence Price Select
NM_000345, 225690599 NP_000336, 4507109 alpha-synuclein isoform NACP140 ORF Sequence $99.00
NM_001146054, 225690601 NP_001139526, 225690602 alpha-synuclein isoform NACP140 ORF Sequence $99.00
NM_001146055, 225690603 NP_001139527, 225690604 alpha-synuclein isoform NACP140 ORF Sequence $99.00
NM_007308, 225690600 NP_009292, 6806898 alpha-synuclein isoform NACP112 ORF Sequence $99.00
KEGG
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
WikiPathways
WP2359Parkin-Ubiquitin Proteasomal System pathway
WP2059Alzheimers Disease
WP2371Parkinsons Disease Pathway
WP437EGFR1 Signaling Pathway
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
Reactome
REACT_116125Disease
REACT_75925Amyloids
Homo sapiens (human)SNCANP_000336.1
Pan troglodytes (chimpanzee)SNCANP_001009158.1
Canis lupus familiaris (dog)SNCAXP_535656.1
Bos taurus (cattle)SNCANP_001029213.1
Mus musculus (house mouse)SncaNP_001035916.1
Rattus norvegicus (Norway rat)SncaNP_062042.1
Gallus gallus (chicken)SNCANP_990004.1
GeneCards SNCA
PDB 3Q28, 1XQ8, 3Q29, 2JN5, 3Q26, 2X6M, 2KKW, 3Q25, 3Q27
UniProt H6UYS5, P37840
MIM 163890
Ensembl ENSG00000145335
HGNC 11138
HPRD 01227

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Interactant



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