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SNCA synuclein, alpha (non A4 component of amyloid precursor) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000345 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001146054 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001146055 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_007308 Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 4, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Gene Symbol SNCA
Entrez Gene ID 6622
Full Name synuclein, alpha (non A4 component of amyloid precursor)
Synonyms NACP, PARK1, PARK4, PD1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009].

MIM: 163890

Parkinson disease 4, 605543 (3); Dementia, Lewy body, 127750 (3);

mRNA Protein Product Sequence Price Select
NM_000345, 225690599 NP_000336, 4507109 alpha-synuclein isoform NACP140 ORF Sequence $99.00
NM_001146054, 225690601 NP_001139526, 225690602 alpha-synuclein isoform NACP140 ORF Sequence $99.00
NM_001146055, 225690603 NP_001139527, 225690604 alpha-synuclein isoform NACP140 ORF Sequence $99.00
NM_007308, 225690600 NP_009292, 6806898 alpha-synuclein isoform NACP112 ORF Sequence $99.00
hsa05012Parkinson's disease
hsa05010Alzheimer's disease
WP437EGFR1 Signaling Pathway
WP2359Parkin-Ubiquitin Proteasomal System pathway
WP2371Parkinsons Disease Pathway
WP2059Alzheimers Disease
Pathway Interaction Database
alphasynuclein_pathwayAlpha-synuclein signaling
Homo sapiens (human)SNCANP_001139527.1
Pan troglodytes (chimpanzee)SNCANP_001009158.1
Canis lupus familiaris (dog)SNCAXP_860942.1
Bos taurus (cattle)SNCANP_001029213.1
Mus musculus (house mouse)SncaNP_001035916.1
Rattus norvegicus (Norway rat)SncaNP_062042.1
Gallus gallus (chicken)SNCANP_990004.1
Xenopus (Silurana) tropicalis (western clawed frog)sncaNP_001090876.1
GO:0001774microglial cell activationIEA
GO:0001921positive regulation of receptor recyclingIDA
GO:0001933negative regulation of protein phosphorylationIEA
GO:0001956positive regulation of neurotransmitter secretionIEA
GO:0006631fatty acid metabolic processIEA
GO:0006638neutral lipid metabolic processIEA
GO:0006644phospholipid metabolic processIEA
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processIDA
GO:0007006mitochondrial membrane organizationIEA
GO:0008344adult locomotory behaviorIEA
GO:0010040response to iron(II) ionIDA
GO:0010517regulation of phospholipase activityIDA
GO:0010642negative regulation of platelet-derived growth factor receptor signaling pathwayIDA
GO:0014048regulation of glutamate secretionIEA
GO:0014059regulation of dopamine secretionTAS
GO:0031115negative regulation of microtubule polymerizationIDA
GO:0031623receptor internalizationIDA
GO:0031648protein destabilizationIDA
GO:0032026response to magnesium ionIDA
GO:0032410negative regulation of transporter activityIDA
GO:0032496response to lipopolysaccharideIDA
GO:0032769negative regulation of monooxygenase activityIDA
GO:0033138positive regulation of peptidyl-serine phosphorylationISS
GO:0034341response to interferon-gammaIDA
GO:0034599cellular response to oxidative stressIEA
GO:0035067negative regulation of histone acetylationIDA
GO:0040012regulation of locomotionIEA
GO:0042416dopamine biosynthetic processTAS
GO:0042493response to drugIEA
GO:0042775mitochondrial ATP synthesis coupled electron transportIEA
GO:0043030regulation of macrophage activationIEA
GO:0043066negative regulation of apoptotic processIMP
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMP
GO:0043206extracellular fibril organizationTAS
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0044344cellular response to fibroblast growth factor stimulusIEA
GO:0045807positive regulation of endocytosisIDA
GO:0045920negative regulation of exocytosisIMP
GO:0045963negative regulation of dopamine metabolic processIEA
GO:0048148behavioral response to cocaineIEA
GO:0048169regulation of long-term neuronal synaptic plasticityIEA
GO:0048488synaptic vesicle endocytosisISS
GO:0050808synapse organizationIEA
GO:0050812regulation of acyl-CoA biosynthetic processIEA
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIDA
GO:0051583dopamine uptake involved in synaptic transmissionTAS
GO:0051585negative regulation of dopamine uptake involved in synaptic transmissionIDA
GO:0051612negative regulation of serotonin uptakeIDA
GO:0051622negative regulation of norepinephrine uptakeIDA
GO:0055074calcium ion homeostasisIDA
GO:0055114oxidation-reduction processIDA
GO:0060079regulation of excitatory postsynaptic membrane potentialIEA
GO:0060291long-term synaptic potentiationIEA
GO:0060732positive regulation of inositol phosphate biosynthetic processIDA
GO:0070495negative regulation of thrombin receptor signaling pathwayIDA
GO:0070555response to interleukin-1IDA
GO:0071280cellular response to copper ionIDA
GO:0071872cellular response to epinephrine stimulusTAS
GO:0071902positive regulation of protein serine/threonine kinase activityIDA
GO:1901214regulation of neuron deathIGI
GO:0005576extracellular regionTAS
GO:0005640nuclear outer membraneIEA
GO:0005791rough endoplasmic reticulumIEA
GO:0005794Golgi apparatusIEA
GO:0005886plasma membraneIDA
GO:0005938cell cortexIDA
GO:0008021synaptic vesicleIEA
GO:0015629actin cytoskeletonIDA
GO:0016234inclusion bodyIDA
GO:0030054cell junctionIEA
GO:0030426growth coneIDA
GO:0031092platelet alpha granule membraneIDA
GO:0043195terminal boutonIEA
GO:0048471perinuclear region of cytoplasmIDA
GO:0000287magnesium ion bindingIDA
GO:0005504fatty acid bindingIDA
GO:0005507copper ion bindingIDA
GO:0005509calcium ion bindingIDA
GO:0005515protein bindingIPI
GO:0005543phospholipid bindingIEA
GO:0008017microtubule bindingIEA
GO:0008198ferrous iron bindingIDA
GO:0008270zinc ion bindingIDA
GO:0016491oxidoreductase activityIDA
GO:0019894kinesin bindingIPI
GO:0019904protein domain specific bindingIEA
GO:0030544Hsp70 protein bindingIPI
GO:0042393histone bindingIDA
GO:0042802identical protein bindingIPI
GO:0043014alpha-tubulin bindingIPI
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic processIDA
GO:0043274phospholipase bindingIEA
GO:0045502dynein bindingIPI
GO:0047485protein N-terminus bindingIEA
GO:0048156tau protein bindingIDA
GO:0048487beta-tubulin bindingIEA
GO:0051219phosphoprotein bindingIDA
GO:0060961phospholipase D inhibitor activityIDA
GeneCards SNCA
UniProt H6UYS5, P37840
MIM 163890
Ensembl ENSG00000145335
HGNC 11138
HPRD 01227

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SNCA gene?

The SNCA gene provides instructions for making a small protein called alpha-synuclein. Alpha-synuclein is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. In the brain, alpha-synuclein is found mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals. Within these structures, alpha-synuclein interacts with fats (lipids) and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function.

Although the function of alpha-synuclein is not well understood, studies suggest that it plays an important role in maintaining a supply of synaptic vesicles in presynaptic terminals. It may also help regulate the release of dopamine, a type of neurotransmitter that is critical for controlling the start and stop of voluntary and involuntary movements.


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