SNRPA small nuclear ribonucleoprotein polypeptide A [Homo sapiens (human)]
| Gene Symbol | SNRPA |
| Entrez Gene ID | 6626 |
| Full Name | small nuclear ribonucleoprotein polypeptide A |
| Synonyms | Mud1, U1-A, U1A |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19q13.1 |
| Summary | The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq]. |
| Disorder | MIM: 182285 |
| mRNA | NM_004596, 295317321 |
| Protein | NP_004587, 4759156 |
| Product | U1 small nuclear ribonucleoprotein A |
| RefSeq Status | REVIEWED |
| hsa03040 | Spliceosome |
WikiPathways
| WP411 | mRNA processing |
Reactome
| REACT_71 | Gene Expression |
| REACT_1735 | mRNA Splicing |
| REACT_125 | Processing of Capped Intron-Containing Pre-mRNA |
| REACT_2039 | Formation and Maturation of mRNA Transcript |
| REACT_1675 | mRNA Processing |
| REACT_467 | mRNA Splicing - Major Pathway |
| Homo sapiens (human) | SNRPA | NP_004587.1 |
| Pan troglodytes (chimpanzee) | SNRPA | XP_512674.2 |
| Canis lupus familiaris (dog) | SNRPA | XP_533663.2 |
| Bos taurus (cattle) | SNRPA | NP_001039504.1 |
| Mus musculus (house mouse) | Snrpa | NP_001040102.1 |
| Rattus norvegicus (Norway rat) | Snrpa | NP_001008304.1 |
| Danio rerio (zebrafish) | snrpa | NP_955965.1 |
| Drosophila melanogaster (fruit fly) | snf | NP_511045.1 |
| Caenorhabditis elegans | rnp-2 | NP_500504.1 |
| Arabidopsis thaliana (thale cress) | U1A | NP_182280.1 |
| ID | Name | Evidence |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | IC |
| GO:0000398 | nuclear mRNA splicing, via spliceosome | TAS |
| GO:0008380 | RNA splicing | EXP |
| GO:0010467 | gene expression | TAS |
Component
| ID | Name | Evidence |
| GO:0005634 | nucleus | IEA |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005681 | spliceosomal complex | IDA |
Function
| ID | Name | Evidence |
| GO:0000166 | nucleotide binding | IEA |
| GO:0003723 | RNA binding | IEA |
| GO:0005515 | protein binding | IPI |
| GeneCards | SNRPA |
| PDB | 3MUT, 3MUR, 3MUV, 3IWN, 1VC0, 1NU4, 3HHN, 2OJ3, 1U6B, 3EGZ, 1DZ5, 3L3C, 3MUM, 1SJF, 3BO2, 1VC6, 1M5O, 3G8S, 1VC5, 1VBX, 1DRZ, 1SJ4, 2U1A, 1VBY, 3CUL, 3G9C, 1VBZ, 3CUN, 1CX0, 1ZZN, 3UTR, 3K0J, 1AUD, 1OIA, 1M5V, 2A3J, 3IRW, 1FHT, 2OIH, 1M5P, 1M5K, 3PGW, 1VC7, 1URN, 3G96, 3G8T, 3BO3, 3MXH, 3IIN, 1SJ3, 3BO4, 2NZ4 |
| UniProt | P09012 |
| MIM | 182285 |
| Ensembl | ENSG00000077312 |
| HGNC | 11151 |
| HPRD | 01658 |
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