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Sequence in raw or FASTA format:


Blast Method:


FOXL2 forkhead box L2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_023067 Homo sapiens forkhead box L2 (FOXL2), mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

Related Services

Gene Symbol FOXL2
Entrez Gene ID 668
Full Name forkhead box L2
General protein information
Preferred Names
forkhead box protein L2
forkhead box protein L2
forkhead transcription factor FOXL2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jun 2009].

MIM: 605597

Blepharophimosis, epicanthus inversus, and ptosis, type 1, 110100

mRNA Protein Product Sequence Price Select
NM_023067, 239735513 NP_075555, 12751477 forkhead box protein L2 ORF Sequence $400.00
Homo sapiens (human)FOXL2NP_075555.1
Pan troglodytes (chimpanzee)FOXL2XP_526323.2
Macaca mulatta (Rhesus monkey)LOC717906XP_001109917.2
Bos taurus (cattle)FOXL2NP_001026920.1
Mus musculus (house mouse)Foxl2NP_036150.1
Rattus norvegicus (Norway rat)Foxl2XP_003750619.1
Danio rerio (zebrafish)LOC100149117XP_001922861.1
GO:0001541ovarian follicle developmentIMP
GO:0001541ovarian follicle developmentISS
GO:0002074extraocular skeletal muscle developmentIMP
GO:0006309apoptotic DNA fragmentationIMP
GO:0006366transcription from RNA polymerase II promoterIBA
GO:0019101female somatic sex determinationIEA
GO:0030154cell differentiationNAS
GO:0043065positive regulation of apoptotic processIGI
GO:0043065positive regulation of apoptotic processIMP
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIMP
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048048embryonic eye morphogenesisIEA
GO:0060014granulosa cell differentiationIEA
GO:0003677DNA bindingIDA
GO:0003677DNA bindingTAS
GO:0003700sequence-specific DNA binding transcription factor activityISS
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0005515protein bindingIPI
GO:0030331estrogen receptor bindingIEA
GO:0031624ubiquitin conjugating enzyme bindingIPI
GO:0043028cysteine-type endopeptidase regulator activity involved in apoptotic processIMP
GO:0043565sequence-specific DNA bindingIEA
GeneCards FOXL2
UniProt Q53ZD3, P58012
Vega OTTHUMG00000159889
MIM 605597
Ensembl ENSG00000183770
HGNC 1092
HPRD 05723

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the FOXL2 gene?

The FOXL2 gene provides instructions for making a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. On the basis of this role, the FOXL2 protein is called a transcription factor. The protein contains one area where a protein building block (amino acid) called alanine is repeated multiple times. This stretch of alanines is known as a polyalanine tract or poly(A) tract. The function of this poly(A) tract is unknown.

The FOXL2 protein is active in multiple tissues, including the eyelids, the ovaries, and a hormone-producing gland at the base of the brain called the pituitary. It is likely involved in the development of muscles in the eyelids. Before birth and in adulthood, the FOXL2 protein regulates the growth and division (proliferation) of hormone-producing ovarian cells called granulosa cells. This protein is also involved in the breakdown of fats, steroid hormones, and potentially harmful molecules called reactive oxygen species in the ovaries. The FOXL2 protein also plays a role in controlled cell death (apoptosis) in the ovaries.


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