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SPINK1 serine peptidase inhibitor, Kazal type 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28321 NM_003122 Homo sapiens serine peptidase inhibitor, Kazal type 1 (SPINK1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu28321C NM_003122 Homo sapiens serine peptidase inhibitor, Kazal type 1 (SPINK1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol SPINK1
Entrez Gene ID 6690
Full Name serine peptidase inhibitor, Kazal type 1
Synonyms PCTT, PSTI, Spink3, TATI, TCP
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q32

Summary The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008].
Disorder

MIM: 167790

Pancreatitis, hereditary, 167800 (3); {Fibrocalculous pancreatic

mRNA Protein Product Sequence Price Select
NM_003122, 657940887 NP_003113, 45505132 pancreatic secretory trypsin inhibitor precursor ORF Sequence $99.00
WikiPathways
WP2263Prostate Cancer
Homo sapiens (human)SPINK1NP_003113.2
Pan troglodytes (chimpanzee)SPINK1XP_001160275.1
Macaca mulatta (Rhesus monkey)SPINK1XP_001102888.1
Canis lupus familiaris (dog)SPINK1XP_850557.1
Bos taurus (cattle)SPINK1NP_001020519.1
Mus musculus (house mouse)Spink3NP_033284.1
Process
IDNameEvidence
GO:0010751negative regulation of nitric oxide mediated signal transductionIEA
GO:0050732negative regulation of peptidyl-tyrosine phosphorylationIEA
GO:0060046regulation of acrosome reactionIEA
GO:0090281negative regulation of calcium ion importIEA
GO:1900004negative regulation of serine-type endopeptidase activityIEA
GO:2001256regulation of store-operated calcium entryIEA
Component
IDNameEvidence
GO:0005576extracellular regionIEA
Function
IDNameEvidence
GO:0004866endopeptidase inhibitor activityTAS
GO:0004867serine-type endopeptidase inhibitor activityIEA
GO:0005515protein bindingIPI
GeneCards SPINK1
PDB 1HPT, 1CGI, 1CGJ
UniProt P00995
Vega OTTHUMG00000129730
MIM 167790
Ensembl ENSG00000164266
HGNC 11244
HPRD 01341

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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