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Sequence in raw or FASTA format:


Blast Method:


SRY sex determining region Y [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28314D NM_003140 Homo sapiens sex determining region Y (SRY), mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu28314C NM_003140 Homo sapiens sex determining region Y (SRY), mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol SRY
Entrez Gene ID 6736
Full Name sex determining region Y
Synonyms SRXX1, SRXY1, TDF, TDY
General protein information
Preferred Names
sex-determining region Y protein
sex-determining region Y protein
sex-determining region on Y
testis-determining factor on Y
essential protein for sex determination in human males
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008].

MIM: 480000

46XY complete gonadal dysgenesis, 400044 (3); 46XX true

mRNA Protein Product Sequence Price Select
NM_003140, 519666780 NP_003131, 4507225 sex-determining region Y protein ORF Sequence $159.00
Pathway Interaction Database
ar_tf_pathwayRegulation of Androgen receptor activity
Homo sapiens (human)SRYNP_003131.1
Pan troglodytes (chimpanzee)SRYNP_001008988.1
Bos taurus (cattle)SRYNP_001014407.1
GO:0006357regulation of transcription from RNA polymerase II promoterIDA
GO:0006366transcription from RNA polymerase II promoterIDA
GO:0007548sex differentiationIEA
GO:0030154cell differentiationIEA
GO:0030238male sex determinationNAS
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:2000020positive regulation of male gonad developmentIDA
GO:0016607nuclear speckIEA
GO:0003677DNA bindingIDA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDA
GO:0005516calmodulin bindingIEA
GO:0008134transcription factor bindingIPI
GeneCards SRY
PDB 1HRY, 1HRZ, 2GZK, 1J47, 1J46
UniProt A7WPU8, Q05066
MIM 480000
HGNC 11311
HPRD 08364

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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