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SRY sex determining region Y [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003140 Homo sapiens sex determining region Y (SRY), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10

*Business Day

Related Services

Gene Symbol SRY
Entrez Gene ID 6736
Full Name sex determining region Y
Synonyms SRXX1, SRXY1, TDF, TDY
General protein information
Preferred Names
sex-determining region Y protein
Names
sex-determining region Y protein
sex-determining region on Y
testis-determining factor on Y
essential protein for sex determination in human males
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

Y

Yp11.3

Summary This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008].
Disorder

MIM: 480000

46XY complete gonadal dysgenesis, 400044 (3); 46XX true

mRNA Protein Product Sequence Price Select
NM_003140, 519666780 NP_003131, 4507225 sex-determining region Y protein ORF Sequence $159.00
Pathway Interaction Database
ar_tf_pathwayRegulation of Androgen receptor activity
Homo sapiens (human)SRYNP_003131.1
Pan troglodytes (chimpanzee)SRYNP_001008988.1
Bos taurus (cattle)SRYNP_001014407.1
Process
IDNameEvidence
GO:0006357regulation of transcription from RNA polymerase II promoterIDA
GO:0006366transcription from RNA polymerase II promoterIDA
GO:0007548sex differentiationIEA
GO:0030154cell differentiationIEA
GO:0030238male sex determinationNAS
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:2000020positive regulation of male gonad developmentIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusNAS
GO:0005737cytoplasmIEA
GO:0016607nuclear speckIEA
Function
IDNameEvidence
GO:0003677DNA bindingIDA
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDA
GO:0005516calmodulin bindingIEA
GO:0008134transcription factor bindingIPI
GeneCards SRY
PDB 1HRY, 1HRZ, 2GZK, 1J47, 1J46
UniProt A7WPU8, Q05066
MIM 480000
HGNC 11311
HPRD 08364

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SRY gene?

The SRY gene provides instructions for making a transcription factor called the sex-determining region Y protein. A transcription factor is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The sex-determining region Y protein causes a fetus to develop as a male.

People normally have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Females have two X chromosomes (46,XX), and males have one X chromosome and one Y chromosome (46,XY). The SRY gene is located on the Y chromosome.

Interactant

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