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Sequence in raw or FASTA format:


Blast Method:


SRY sex determining region Y [Homo sapiens (human)]

RefSeq Accession Definition Services Price Order
NM_003140 Homo sapiens sex determining region Y (SRY), mRNA. ORF Sequence $178.35
Peptide Services
Antibody Services
Protein Services

Gene Symbol SRY
Entrez Gene ID 6736
Full Name sex determining region Y
Synonyms TDF, TDY
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008].

MIM: 480000

46XY complete gonadal dysgenesis, 400044 (3); 46XX true

mRNA Protein Product Sequence Price Select
NM_003140, 4507224 NP_003131, 4507225 sex-determining region Y protein Full Length $260.13
ORF Sequence $178.35
Pathway Interaction Database
ar_tf_pathwayRegulation of Androgen receptor activity
Homo sapiens (human)SRYNP_003131.1
Pan troglodytes (chimpanzee)SRYNP_001008988.1
Bos taurus (cattle)SRYNP_001014407.1
GeneCards SRY
PDB 1HRY, 1HRZ, 2GZK, 1J47, 1J46
UniProt A7WPU8, Q05066
MIM 480000
Ensembl ENSG00000184895
HGNC 11311
HPRD 08364

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
sex-determining region Y protein
sex-determining region Y protein
sex-determining region on Y
testis-determining factor on Y
essential protein for sex determination in human males


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