• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003150 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_139276 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_213662 Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol STAT3
Entrez Gene ID 6774
Full Name signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms APRF, FLJ20882, HIES, MGC16063
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q21.31

Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder

MIM: 102582

Hyper-IgE recurrent infection syndrome, 147060 (3)

mRNA Protein Product Sequence Price Select
NM_003150, 47080105 NP_003141, 21618338 signal transducer and activator of transcription 3 isoform 2 ORF Sequence $660.00
NM_139276, 47080104 NP_644805, 21618340 signal transducer and activator of transcription 3 isoform 1 ORF Sequence $660.00
NM_213662, 47458819 NP_998827, 47458820 signal transducer and activator of transcription 3 isoform 3 ORF Sequence $700.00
KEGG
hsa05212Pancreatic cancer
hsa05162Measles
hsa04630Jak-STAT signaling pathway
hsa04062Chemokine signaling pathway
hsa04066HIF-1 signaling pathway
hsa05203Viral carcinogenesis
hsa05200Pathways in cancer
hsa05161Hepatitis B
hsa05169Epstein-Barr virus infection
hsa04920Adipocytokine signaling pathway
hsa05160Hepatitis C
hsa05145Toxoplasmosis
hsa05221Acute myeloid leukemia
Pathway Interaction Database
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
il6_7pathwayIL6-mediated signaling events
hes_heypathwayNotch-mediated HES/HEY network
hdac_classi_pathwaySignaling events mediated by HDAC Class I
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
il23pathwayIL23-mediated signaling events
il12_2pathwayIL12-mediated signaling events
erbb1_downstream_pathwayErbB1 downstream signaling
tcptp_pathwaySignaling events mediated by TCPTP
erbb2erbb3pathwayErbB2/ErbB3 signaling events
ifngpathwayIFN-gamma pathway
trkrpathwayNeurotrophic factor-mediated Trk receptor signaling
il27pathwayIL27-mediated signaling events
il12_stat4pathwayIL12 signaling mediated by STAT4
cxcr4_pathwayCXCR4-mediated signaling events
ptp1bpathwaySignaling events mediated by PTP1B
rac1_pathwayRAC1 signaling pathway
il2_1pathwayIL2-mediated signaling events
pdgfrbpathwayPDGFR-beta signaling pathway
WikiPathways
WP286IL-3 Signaling Pathway
WP364IL-6 Signaling Pathway
WP22IL-9 Signaling Pathway
WP2037Prolactin Signaling Pathway
WP205IL-7 Signaling Pathway
WP313Signaling of Hepatocyte Growth Factor Receptor
WP2374Oncostatin M Signaling Pathway
WP2324AGE/RAGE pathway
WP581EPO Receptor Signaling
WP23B Cell Receptor Signaling Pathway
WP236Adipogenesis
WP437EGFR1 Signaling Pathway
WP2332Interleukin-11 Signaling Pathway
WP138Androgen receptor signaling pathway
WP2034Leptin signaling pathway
WP1559TFs Regulate miRNAs related to cardiac hypertrophy
WP2032TSH signaling pathway
WP127IL-5 Signaling Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP61Delta-Notch Signaling Pathway
WP560TGF Beta Signaling Pathway
WP304Kit Receptor Signaling Pathway
WP49IL-2 Signaling Pathway
WP2203TSLP Signaling Pathway
Reactome
REACT_121141Signaling by FGFR1 fusion mutants
REACT_75790Cytokine Signaling in Immune system
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_27307Interleukin-6 signaling
REACT_17025Downstream signal transduction
REACT_111102Signal Transduction
REACT_116125Disease
REACT_111133Growth hormone receptor signaling
REACT_12049Signalling to STAT3
REACT_120999Signaling by FGFR1 mutants
REACT_111040Signaling by SCF-KIT
REACT_22232Signaling by Interleukins
REACT_6900Immune System
REACT_120736Signaling by FGFR in disease
REACT_11061Signalling by NGF
REACT_16888Signaling by PDGF
REACT_121398Signaling by FGFR mutants
Homo sapiens (human)STAT3NP_003141.2
Pan troglodytes (chimpanzee)STAT3XP_001165417.2
Macaca mulatta (Rhesus monkey)STAT3XP_002800523.1
Canis lupus familiaris (dog)STAT3XP_548090.2
Bos taurus (cattle)STAT3NP_001012689.2
Mus musculus (house mouse)Stat3NP_998825.1
Rattus norvegicus (Norway rat)Stat3NP_036879.1
Gallus gallus (chicken)STAT3NP_001026102.1
Danio rerio (zebrafish)stat3NP_571554.1
GeneCards STAT3
UniProt P40763, K7ENL3
MIM 102582
Ensembl ENSG00000168610
HGNC 11364
HPRD 00026

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
signal transducer and activator of transcription 3
Names
signal transducer and activator of transcription 3
DNA-binding protein APRF
acute-phase response factor

Interactant



Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Learn more about the GenEZ ORF Cloning Service.