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STAT4 signal transducer and activator of transcription 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001243835 Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_003151 Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
XM_005246817 PREDICTED: Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006712719 PREDICTED: Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Related Services

Gene Symbol STAT4
Entrez Gene ID 6775
Full Name signal transducer and activator of transcription 4
Synonyms SLEB11
General protein information
Preferred Names
signal transducer and activator of transcription 4
Names
signal transducer and activator of transcription 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q32.2-q32.3

Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].
Disorder

MIM: 600558

{Rheumatoid arthritis, association with}, 180300 (3); {Systemic

mRNA Protein Product Sequence Price Select
NM_001243835, 345110659 NP_001230764, 345110660 signal transducer and activator of transcription 4 ORF Sequence $490.00
NM_003151, 345110658 NP_003142, 4507255 signal transducer and activator of transcription 4 ORF Sequence $490.00
XM_005246817, 578804822 XP_005246874, 530370886 signal transducer and activator of transcription 4 isoform X1 ORF Sequence $700.00
XM_006712719, 578804823 XP_006712782, 578804824 signal transducer and activator of transcription 4 isoform X2 ORF Sequence $700.00
KEGG
hsa04630Jak-STAT signaling pathway
hsa05161Hepatitis B
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP2203TSLP Signaling Pathway
WP585Interferon type I
Pathway Interaction Database
il27pathwayIL27-mediated signaling events
il12_stat4pathwayIL12 signaling mediated by STAT4
il12_2pathwayIL12-mediated signaling events
il23pathwayIL23-mediated signaling events
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
Homo sapiens (human)STAT4NP_001230764.1
Pan troglodytes (chimpanzee)STAT4XP_003309420.1
Macaca mulatta (Rhesus monkey)STAT4XP_002799067.1
Canis lupus familiaris (dog)STAT4XP_005640526.1
Bos taurus (cattle)STAT4NP_001077161.2
Mus musculus (house mouse)Stat4NP_035617.1
Rattus norvegicus (Norway rat)Stat4NP_001012226.1
Gallus gallus (chicken)STAT4NP_001254484.1
Danio rerio (zebrafish)stat4NP_001004510.1
Xenopus (Silurana) tropicalis (western clawed frog)stat4XP_002937488.2
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0006468protein phosphorylationIEA
GO:0007259JAK-STAT cascadeTAS
GO:0008283cell proliferationIEA
GO:0019221cytokine-mediated signaling pathwayIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0004871signal transducer activityIEA
GO:0005509calcium ion bindingIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards STAT4
UniProt Q14765
Vega OTTHUMG00000132700
MIM 600558
Ensembl ENSG00000138378
HGNC 11365
HPRD 02779

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the STAT4 gene?

The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. The STAT4 protein is turned on (activated) by immune system proteins called cytokines, which are part of the inflammatory response to fight infection. When activated, the STAT4 protein increases the activity of genes that help immune cells called T-cells mature into specialized T-cells. These specialized T-cells, called Th1 cells, produce specific cytokines and stimulate other immune cells to get rid of foreign invaders (pathogens) in the cell.

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