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STAT4 signal transducer and activator of transcription 4 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18290 NM_003151 Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu18290 NM_001243835 Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu36570 XM_005246817 PREDICTED: Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu18290 XM_006712719 PREDICTED: Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu18290C NM_003151 Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu18290C NM_001243835 Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu36570C XM_005246817 PREDICTED: Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu18290C XM_006712719 PREDICTED: Homo sapiens signal transducer and activator of transcription 4 (STAT4), transcript variant X2, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol STAT4
Entrez Gene ID 6775
Full Name signal transducer and activator of transcription 4
Synonyms SLEB11
General protein information
Preferred Names
signal transducer and activator of transcription 4
Names
signal transducer and activator of transcription 4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q32.2-q32.3

Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].
Disorder

MIM: 600558

{Rheumatoid arthritis, association with}, 180300 (3); {Systemic

mRNA Protein Product Sequence Price Select
NM_001243835, 345110659 NP_001230764, 345110660 signal transducer and activator of transcription 4 ORF Sequence $490.00
NM_003151, 345110658 NP_003142, 4507255 signal transducer and activator of transcription 4 ORF Sequence $490.00
XM_005246817, 578804822 XP_005246874, 530370886 signal transducer and activator of transcription 4 isoform X1 ORF Sequence $700.00
XM_006712719, 578804823 XP_006712782, 578804824 signal transducer and activator of transcription 4 isoform X2 ORF Sequence $700.00
KEGG
hsa04630Jak-STAT signaling pathway
hsa05161Hepatitis B
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP2203TSLP Signaling Pathway
WP585Interferon type I
Pathway Interaction Database
il27pathwayIL27-mediated signaling events
il12_stat4pathwayIL12 signaling mediated by STAT4
il12_2pathwayIL12-mediated signaling events
il23pathwayIL23-mediated signaling events
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
Homo sapiens (human)STAT4NP_001230764.1
Pan troglodytes (chimpanzee)STAT4XP_003309420.1
Macaca mulatta (Rhesus monkey)STAT4XP_002799067.1
Canis lupus familiaris (dog)STAT4XP_005640526.1
Bos taurus (cattle)STAT4NP_001077161.2
Mus musculus (house mouse)Stat4NP_035617.1
Rattus norvegicus (Norway rat)Stat4NP_001012226.1
Gallus gallus (chicken)STAT4NP_001254484.1
Danio rerio (zebrafish)stat4NP_001004510.1
Xenopus (Silurana) tropicalis (western clawed frog)stat4XP_002937488.2
Process
IDNameEvidence
GO:0006351transcription, DNA-templatedIEA
GO:0006468protein phosphorylationIEA
GO:0007259JAK-STAT cascadeTAS
GO:0008283cell proliferationIEA
GO:0019221cytokine-mediated signaling pathwayIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0004871signal transducer activityIEA
GO:0005509calcium ion bindingIEA
GO:0043565sequence-specific DNA bindingIEA
GeneCards STAT4
UniProt Q14765
Vega OTTHUMG00000132700
MIM 600558
Ensembl ENSG00000138378
HGNC 11365
HPRD 02779

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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