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STAT5B signal transducer and activator of transcription 5B [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_012448 Homo sapiens signal transducer and activator of transcription 5B (STAT5B), mRNA. ORF Sequence $685.56
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Gene Symbol STAT5B
Entrez Gene ID 6777
Full Name signal transducer and activator of transcription 5B
Synonyms STAT5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2

Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604260

Leukemia, acute promyelocytic, STAT5B/RARA type (3); Growth hormone

mRNA Protein Product Sequence Price Select
NM_012448, 42519913 NP_036580, 21618344 signal transducer and activator of transcription 5B Full Length $2326.95
ORF Sequence $685.56
KEGG
hsa05200Pathways in cancer
hsa05221Acute myeloid leukemia
hsa04062Chemokine signaling pathway
hsa05220Chronic myeloid leukemia
hsa05203Viral carcinogenesis
hsa04630Jak-STAT signaling pathway
hsa05161Hepatitis B
hsa05162Measles
hsa04012ErbB signaling pathway
hsa05166HTLV-I infection
Pathway Interaction Database
epopathwayEPO signaling pathway
il4_2pathwayIL4-mediated signaling events
ptp1bpathwaySignaling events mediated by PTP1B
fgf_pathwayFGF signaling pathway
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
erbb4_pathwayErbB4 signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
tcptp_pathwaySignaling events mediated by TCPTP
il2_1pathwayIL2-mediated signaling events
il2_stat5pathwayIL2 signaling events mediated by STAT5
cxcr4_pathwayCXCR4-mediated signaling events
pdgfrbpathwayPDGFR-beta signaling pathway
WikiPathways
WP286IL-3 Signaling Pathway
WP2037Prolactin Signaling Pathway
WP205IL-7 Signaling Pathway
WP22IL-9 Signaling Pathway
WP304Kit Receptor Signaling Pathway
WP2374Oncostatin M Signaling Pathway
WP2324AGE/RAGE pathway
WP581EPO Receptor Signaling
WP236Adipogenesis
WP437EGFR1 Signaling Pathway
WP2034Leptin signaling pathway
WP127IL-5 Signaling Pathway
WP474Endochondral Ossification
WP49IL-2 Signaling Pathway
WP2203TSLP Signaling Pathway
Reactome
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_111133Growth hormone receptor signaling
REACT_111102Signal Transduction
REACT_115529Interleukin-7 signaling
REACT_6900Immune System
REACT_116022Nuclear signaling by ERBB4
REACT_27283Interleukin-2 signaling
REACT_121141Signaling by FGFR1 fusion mutants
REACT_120736Signaling by FGFR in disease
REACT_111040Signaling by SCF-KIT
REACT_75790Cytokine Signaling in Immune system
REACT_115596Signaling by ERBB4
REACT_116125Disease
REACT_120999Signaling by FGFR1 mutants
REACT_16888Signaling by PDGF
REACT_17025Downstream signal transduction
REACT_22232Signaling by Interleukins
REACT_115697Prolactin receptor signaling
REACT_121398Signaling by FGFR mutants
Homo sapiens (human)STAT5BNP_036580.2
Pan troglodytes (chimpanzee)STAT5BXP_001166251.1
Macaca mulatta (Rhesus monkey)STAT5BXP_001109317.2
Canis lupus familiaris (dog)STAT5BXP_548092.1
Bos taurus (cattle)STAT5BNP_777042.2
Mus musculus (house mouse)Stat5bNP_001107035.1
Rattus norvegicus (Norway rat)Stat5bNP_071775.1
Gallus gallus (chicken)STAT5BNP_990110.1
Danio rerio (zebrafish)stat5.2NP_001003984.1
Danio rerio (zebrafish)stat5.1NP_919368.1
Caenorhabditis eleganssta-1NP_001122815.1
GeneCards STAT5B
UniProt P51692
MIM 604260
Ensembl ENSG00000173757
HGNC 11367
HPRD 05037

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
signal transducer and activator of transcription 5B
Names
signal transducer and activator of transcription 5B
transcription factor STAT5B

Interactant

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