STAT5B signal transducer and activator of transcription 5B [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	STAT5B
Entrez Gene ID	6777
Full Name	signal transducer and activator of transcription 5B
Synonyms	STAT5
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:17 Map Location:17q11.2
Summary	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq].
Disorder	MIM: 604260 Leukemia, acute promyelocytic, STAT5B/RARA type (3); Growth hormone

mRNA	NM_012448, 42519913
Protein	NP_036580, 21618344
Product	signal transducer and activator of transcription 5B
RefSeq Status	REVIEWED

KEGG

hsa05200	Pathways in cancer
hsa05220	Chronic myeloid leukemia
hsa04062	Chemokine signaling pathway
hsa04012	ErbB signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa05221	Acute myeloid leukemia

Pathway Interaction Database

ptp1bpathway	Signaling events mediated by PTP1B
fgf_pathway	FGF signaling pathway
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
erbb4_pathway	ErbB4 signaling events
reg_gr_pathway	Glucocorticoid receptor regulatory network
tcptp_pathway	Signaling events mediated by TCPTP
il2_stat5pathway	IL2 signaling events mediated by STAT5
il2_1pathway	IL2-mediated signaling events
cxcr4_pathway	CXCR4-mediated signaling events
pdgfrbpathway	PDGFR-beta signaling pathway
il4_2pathway	IL4-mediated signaling events
epopathway	EPO signaling pathway

WikiPathways

WP304	Kit Receptor Signaling Pathway
WP205	IL-7 Signaling Pathway
WP236	Adipogenesis
WP581	EPO Receptor Signaling
WP437	EGFR1 Signaling Pathway
WP127	IL-5 Signaling Pathway
WP69	T Cell Receptor Signaling Pathway
WP474	Endochondral Ossification
WP49	IL-2 Signaling Pathway
WP286	IL-3 Signaling Pathway
WP22	IL-9 Signaling Pathway

Reactome

REACT_16888	Signaling by PDGF
REACT_17025	Down-stream signal transduction
REACT_22232	Signaling by Interleukins
REACT_6900	Signaling in Immune system
REACT_23837	Interleukin-3, 5 and GM-CSF signaling

Homo sapiens (human)	STAT5B	NP_036580.2
Pan troglodytes (chimpanzee)	STAT5B	XP_001166221.1
Canis lupus familiaris (dog)	STAT5B	XP_860054.1
Bos taurus (cattle)	STAT5B	NP_777042.2
Mus musculus (house mouse)	Stat5b	NP_035619.2
Rattus norvegicus (Norway rat)	Stat5b	NP_071775.1
Gallus gallus (chicken)	STAT5B	NP_990110.1
Danio rerio (zebrafish)	stat5.2	NP_001003984.1
Danio rerio (zebrafish)	stat5.1	NP_919368.1
Caenorhabditis elegans	sta-1	NP_001122815.1

Process

ID	Name	Evidence
GO:0000255	allantoin metabolic process	ISS
GO:0001553	luteinization	IEA
GO:0001666	response to hypoxia	IEA
GO:0001889	liver development	IEA
GO:0006101	citrate metabolic process	ISS
GO:0006103	2-oxoglutarate metabolic process	ISS
GO:0006105	succinate metabolic process	ISS
GO:0006107	oxaloacetate metabolic process	ISS
GO:0006351	transcription, DNA-dependent	TAS
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS
GO:0006549	isoleucine metabolic process	ISS
GO:0006573	valine metabolic process	ISS
GO:0006600	creatine metabolic process	ISS
GO:0006631	fatty acid metabolic process	ISS
GO:0006953	acute-phase response	IEA
GO:0007259	JAK-STAT cascade	TAS
GO:0007548	sex differentiation	IEA
GO:0007565	female pregnancy	IEA
GO:0007595	lactation	IEA
GO:0019218	regulation of steroid metabolic process	IEA
GO:0019221	cytokine-mediated signaling pathway	IEA
GO:0019530	taurine metabolic process	ISS
GO:0019915	lipid storage	IEA
GO:0030155	regulation of cell adhesion	IEA
GO:0030856	regulation of epithelial cell differentiation	IEA
GO:0032355	response to estradiol stimulus	IDA
GO:0032496	response to lipopolysaccharide	IEA
GO:0032819	positive regulation of natural killer cell proliferation	IEA
GO:0032825	positive regulation of natural killer cell differentiation	IEA
GO:0032870	cellular response to hormone stimulus	IDA
GO:0033077	T cell differentiation in thymus	IEA
GO:0040014	regulation of multicellular organism growth	ISS
GO:0040018	positive regulation of multicellular organism growth	IEA
GO:0042104	positive regulation of activated T cell proliferation	IEA
GO:0042448	progesterone metabolic process	IEA
GO:0043029	T cell homeostasis	IEA
GO:0043066	negative regulation of apoptosis	IEA
GO:0043434	response to peptide hormone stimulus	IEA
GO:0045086	positive regulation of interleukin-2 biosynthetic process	IEA
GO:0045471	response to ethanol	IEA
GO:0045579	positive regulation of B cell differentiation	IEA
GO:0045588	positive regulation of gamma-delta T cell differentiation	IEA
GO:0045647	negative regulation of erythrocyte differentiation	IEA
GO:0045885	positive regulation of survival gene product expression	IEA
GO:0045931	positive regulation of mitotic cell cycle	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IEA
GO:0046449	creatinine metabolic process	ISS
GO:0046543	development of secondary female sexual characteristics	IEA
GO:0046544	development of secondary male sexual characteristics	IEA
GO:0048541	Peyer's patch development	IEA
GO:0048661	positive regulation of smooth muscle cell proliferation	IEA
GO:0050729	positive regulation of inflammatory response	IEA
GO:0051272	positive regulation of cellular component movement	IEA
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	IDA
GO:0070669	response to interleukin-2	IEA
GO:0070670	response to interleukin-4	IEA
GO:0070672	response to interleukin-15	IEA

Component

ID	Name	Evidence
GO:0005634	nucleus	IEA
GO:0005654	nucleoplasm	EXP
GO:0005737	cytoplasm	IEA
GO:0005829	cytosol	EXP
GO:0005829	cytosol	TAS

Function

ID	Name	Evidence
GO:0003690	double-stranded DNA binding	IEA
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA
GO:0004871	signal transducer activity	IEA
GO:0005509	calcium ion binding	IEA
GO:0005515	protein binding	IPI
GO:0035259	glucocorticoid receptor binding	IPI
GO:0043565	sequence-specific DNA binding	IEA

GeneCards	STAT5B
UniProt	P51692
MIM	604260
Ensembl	ENSG00000173757
HGNC	11367
HPRD	05037

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RefSeq Accession	Definition	Sequence	Price	Select
NM_012448	Homo sapiens signal transducer and activator of transcription 5B (STAT5B), mRNA.	Full Length	$2326.95
NM_012448		ORF Sequence	$685.56