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STAT5B signal transducer and activator of transcription 5B [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25538 NM_012448 Homo sapiens signal transducer and activator of transcription 5B (STAT5B), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu50617 XM_005257625 PREDICTED: Homo sapiens signal transducer and activator of transcription 5B (STAT5B), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu50618 XM_005257626 PREDICTED: Homo sapiens signal transducer and activator of transcription 5B (STAT5B), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25538C NM_012448 Homo sapiens signal transducer and activator of transcription 5B (STAT5B), mRNA. Customized vector On-demand 12-14 $329.00
OHu50617C XM_005257625 PREDICTED: Homo sapiens signal transducer and activator of transcription 5B (STAT5B), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00
OHu50618C XM_005257626 PREDICTED: Homo sapiens signal transducer and activator of transcription 5B (STAT5B), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol STAT5B
Entrez Gene ID 6777
Full Name signal transducer and activator of transcription 5B
Synonyms STAT5
General protein information
Preferred Names
signal transducer and activator of transcription 5B
Names
signal transducer and activator of transcription 5B
transcription factor STAT5B
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2

Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].
Disorder

MIM: 604260

Leukemia, acute promyelocytic, STAT5B/RARA type (3); Growth hormone

mRNA Protein Product Sequence Price Select
NM_012448, 42519913 NP_036580, 21618344 signal transducer and activator of transcription 5B ORF Sequence $750.00
XM_005257625, 530412764 XP_005257682, 530412765 signal transducer and activator of transcription 5B isoform X1 ORF Sequence $700.00
XM_005257626, 578831312 XP_005257683, 530412767 signal transducer and activator of transcription 5B isoform X2 ORF Sequence $550.00
KEGG
hsa04012ErbB signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa05220Chronic myeloid leukemia
hsa04062Chemokine signaling pathway
hsa05166HTLV-I infection
hsa05162Measles
hsa05161Hepatitis B
hsa05203Viral carcinogenesis
hsa04917Prolactin signaling pathway
WikiPathways
WP127IL-5 Signaling Pathway
WP437EGFR1 Signaling Pathway
WP474Endochondral Ossification
WP304Kit Receptor Signaling Pathway
WP236Adipogenesis
WP205IL-7 Signaling Pathway
WP49IL-2 Signaling pathway
WP22IL-9 Signaling Pathway
WP581EPO Receptor Signaling
WP286IL-3 Signaling Pathway
WP2324AGE/RAGE pathway
WP2374Oncostatin M Signaling Pathway
WP2380BDNF signaling pathway
WP2034Leptin signaling pathway
WP2037Prolactin Signaling Pathway
WP2203TSLP Signaling Pathway
Pathway Interaction Database
cxcr4_pathwayCXCR4-mediated signaling events
angiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
il2_1pathwayIL2-mediated signaling events
erbb4_pathwayErbB4 signaling events
fgf_pathwayFGF signaling pathway
il2_stat5pathwayIL2 signaling events mediated by STAT5
ptp1bpathwaySignaling events mediated by PTP1B
il4_2pathwayIL4-mediated signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
pdgfrbpathwayPDGFR-beta signaling pathway
epopathwayEPO signaling pathway
tcptp_pathwaySignaling events mediated by TCPTP
Reactome
REACT_16888Signaling by PDGF
REACT_6900Immune System
REACT_17025Downstream signal transduction
REACT_22232Signaling by Interleukins
REACT_27283Interleukin-2 signaling
REACT_75790Cytokine Signaling in Immune system
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_111133Growth hormone receptor signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_116125Disease
REACT_115697Prolactin receptor signaling
REACT_115596Signaling by ERBB4
REACT_116022Nuclear signaling by ERBB4
REACT_115529Interleukin-7 signaling
REACT_121141Signaling by FGFR1 fusion mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_120999Signaling by FGFR1 mutants
REACT_169118Signaling by Leptin
Homo sapiens (human)STAT5BNP_036580.2
Pan troglodytes (chimpanzee)STAT5BXP_001166251.1
Macaca mulatta (Rhesus monkey)STAT5BXP_001109317.2
Canis lupus familiaris (dog)STAT5BXP_548092.1
Bos taurus (cattle)STAT5BNP_777042.2
Mus musculus (house mouse)Stat5bNP_035619.3
Rattus norvegicus (Norway rat)Stat5bNP_071775.1
Gallus gallus (chicken)STAT5BNP_990110.1
Danio rerio (zebrafish)stat5.2NP_001003984.1
Danio rerio (zebrafish)stat5.1NP_919368.1
Caenorhabditis eleganssta-1NP_502974.2
Xenopus (Silurana) tropicalis (western clawed frog)stat5bXP_002943467.1
Process
IDNameEvidence
GO:0000255allantoin metabolic processISS
GO:0001553luteinizationIEA
GO:0001666response to hypoxiaIEA
GO:0001779natural killer cell differentiationIEA
GO:0001889liver developmentIEA
GO:0006101citrate metabolic processISS
GO:00061032-oxoglutarate metabolic processISS
GO:0006105succinate metabolic processISS
GO:0006107oxaloacetate metabolic processISS
GO:0006357regulation of transcription from RNA polymerase II promoterTAS
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0006549isoleucine metabolic processISS
GO:0006573valine metabolic processISS
GO:0006600creatine metabolic processISS
GO:0006631fatty acid metabolic processISS
GO:0006953acute-phase responseIEA
GO:0007259JAK-STAT cascadeTAS
GO:0007565female pregnancyIEA
GO:0007595lactationIEA
GO:0019218regulation of steroid metabolic processIEA
GO:0019530taurine metabolic processISS
GO:0019915lipid storageIEA
GO:0030155regulation of cell adhesionIEA
GO:0030856regulation of epithelial cell differentiationIEA
GO:0032355response to estradiolIDA
GO:0032496response to lipopolysaccharideIEA
GO:0032819positive regulation of natural killer cell proliferationIEA
GO:0032825positive regulation of natural killer cell differentiationIEA
GO:0032870cellular response to hormone stimulusIDA
GO:0033077T cell differentiation in thymusIEA
GO:0038161prolactin signaling pathwayISS
GO:0040014regulation of multicellular organism growthISS
GO:0040018positive regulation of multicellular organism growthIEA
GO:0042104positive regulation of activated T cell proliferationIEA
GO:0042448progesterone metabolic processIEA
GO:0043029T cell homeostasisIEA
GO:0043066negative regulation of apoptotic processIEA
GO:0045086positive regulation of interleukin-2 biosynthetic processIEA
GO:0045471response to ethanolIEA
GO:0045579positive regulation of B cell differentiationIEA
GO:0045588positive regulation of gamma-delta T cell differentiationIEA
GO:0045647negative regulation of erythrocyte differentiationIEA
GO:0045931positive regulation of mitotic cell cycleIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0045954positive regulation of natural killer cell mediated cytotoxicityIEA
GO:0046449creatinine metabolic processISS
GO:0046543development of secondary female sexual characteristicsIEA
GO:0046544development of secondary male sexual characteristicsIEA
GO:0048541Peyer's patch developmentIEA
GO:0048661positive regulation of smooth muscle cell proliferationIEA
GO:0050729positive regulation of inflammatory responseIEA
GO:0051272positive regulation of cellular component movementIEA
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayIDA
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTAS
GO:0070669response to interleukin-2IEA
GO:0070670response to interleukin-4IEA
GO:0070672response to interleukin-15IEA
GO:0071363cellular response to growth factor stimulusISS
GO:0071364cellular response to epidermal growth factor stimulusISS
Component
IDNameEvidence
GO:0005634nucleusISS
GO:0005654nucleoplasmTAS
GO:0005737cytoplasmISS
GO:0005829cytosolTAS
Function
IDNameEvidence
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEA
GO:0003682chromatin bindingISS
GO:0003690double-stranded DNA bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityIEA
GO:0004871signal transducer activityIEA
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0019903protein phosphatase bindingIEA
GO:0035259glucocorticoid receptor bindingIPI
GO:0046983protein dimerization activityISS
GeneCards STAT5B
UniProt P51692
Vega OTTHUMG00000150724
MIM 604260
Ensembl ENSG00000173757
HGNC 11367
HPRD 05037

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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