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CDKL5 cyclin-dependent kinase-like 5 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001037343 Homo sapiens cyclin-dependent kinase-like 5 (CDKL5), transcript variant II, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
NM_003159 Homo sapiens cyclin-dependent kinase-like 5 (CDKL5), transcript variant I, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005274584 PREDICTED: Homo sapiens cyclin-dependent kinase-like 5 (CDKL5), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $1699.00 25
XM_005274585 PREDICTED: Homo sapiens cyclin-dependent kinase-like 5 (CDKL5), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006724511 PREDICTED: Homo sapiens cyclin-dependent kinase-like 5 (CDKL5), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Gene Symbol CDKL5
Entrez Gene ID 6792
Full Name cyclin-dependent kinase-like 5
Synonyms EIEE2, ISSX, STK9
General protein information
Preferred Names
cyclin-dependent kinase-like 5
cyclin-dependent kinase-like 5
serine/threonine kinase 9
serine/threonine-protein kinase 9
cyclin dependent kinase 5 transcript
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].

MIM: 300203

Epileptic encephalopathy, early infantile, 2, 300672 (3);

mRNA Protein Product Sequence Price Select
NM_001037343, 83367068 NP_001032420, 83367069 cyclin-dependent kinase-like 5 ORF Sequence $1500.00
NM_003159, 83367066 NP_003150, 4507281 cyclin-dependent kinase-like 5 ORF Sequence $1500.00
XM_005274584, 530421240 XP_005274641, 530421241 cyclin-dependent kinase-like 5 isoform X1 ORF Sequence $1500.00
XM_005274585, 530421242 XP_005274642, 530421243 cyclin-dependent kinase-like 5 isoform X2 ORF Sequence $750.00
XM_006724511, 578837947 XP_006724574, 578837948 cyclin-dependent kinase-like 5 isoform X3 ORF Sequence $1500.00
WP2380BDNF signaling pathway
Homo sapiens (human)CDKL5NP_001032420.1
Pan troglodytes (chimpanzee)CDKL5XP_003317430.1
Macaca mulatta (Rhesus monkey)LOC693974XP_002808564.1
Canis lupus familiaris (dog)CDKL5XP_005641221.1
Bos taurus (cattle)CDKL5XP_002700425.2
Mus musculus (house mouse)Cdkl5NP_001019795.1
Rattus norvegicus (Norway rat)Cdkl5XP_006256971.1
Gallus gallus (chicken)CDKL5XP_425571.2
Danio rerio (zebrafish)cdkl5NP_001124243.1
Xenopus (Silurana) tropicalis (western clawed frog)cdkl5XP_004911815.1
GO:0001764neuron migrationISS
GO:0006468protein phosphorylationTAS
GO:0032855positive regulation of Rac GTPase activityISS
GO:0045773positive regulation of axon extensionISS
GO:0046777protein autophosphorylationIDA
GO:0050773regulation of dendrite developmentISS
GO:0050775positive regulation of dendrite morphogenesisISS
GO:0051726regulation of cell cycleIEA
GO:0032587ruffle membraneISS
GO:0032839dendrite cytoplasmISS
GO:0044294dendritic growth coneISS
GO:0004672protein kinase activityIDA
GO:0004674protein serine/threonine kinase activityTAS
GO:0004693cyclin-dependent protein serine/threonine kinase activityIEA
GO:0005524ATP bindingIDA
GO:0016301kinase activityIDA
GO:0048365Rac GTPase bindingISS
GeneCards CDKL5
UniProt O76039
Vega OTTHUMG00000021214
MIM 300203
Ensembl ENSG00000008086
HGNC 11411
HPRD 02190

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the CDKL5 gene?

The CDKL5 gene provides instructions for making a protein that is essential for normal brain development and function. The CDKL5 protein acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. One of the proteins targeted by the CDKL5 protein is MeCP2, which is produced from the MECP2 gene. The MeCP2 protein plays important roles in the function of nerve cells (neurons) and other brain cells and in the maintenance of connections (synapses) between neurons. Researchers have not determined which other proteins are targeted by the CDKL5 protein.


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