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STK11 serine/threonine kinase 11 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000455 Homo sapiens serine/threonine kinase 11 (STK11), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12

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Gene Symbol STK11
Entrez Gene ID 6794
Full Name serine/threonine kinase 11
Synonyms LKB1, PJS
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

MIM: 602216

Peutz-Jeghers syndrome, 175200 (3); Melanoma, malignant sporadic (3);

mRNA Protein Product Sequence Price Select
NM_000455, 58530881 NP_000446, 4507271 serine/threonine-protein kinase STK11 ORF Sequence $360.00
hsa04920Adipocytokine signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
Pathway Interaction Database
lkb1_pathwayLKB1 signaling events
WP1984Integrated Breast Cancer Pathway
WP1403AMPK signaling
WP366TGF-beta Receptor Signaling Pathway
WP2256Integrated Pancreatic Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
REACT_498Signaling by Insulin receptor
REACT_21285Regulation of AMPK activity via LKB1
REACT_332IRS-mediated signalling
REACT_111102Signal Transduction
REACT_21387Energy dependent regulation of mTOR by LKB1-AMPK
REACT_1505Integration of energy metabolism
REACT_456PKB-mediated events
REACT_6838mTOR signalling
REACT_762IRS-related events
REACT_1195Insulin receptor signalling cascade
REACT_1988AMPK inhibits chREBP transcriptional activation activity
REACT_976PI3K Cascade
Homo sapiens (human)STK11NP_000446.1
Pan troglodytes (chimpanzee)STK11XP_524028.2
Macaca mulatta (Rhesus monkey)STK11XP_001093806.1
Canis lupus familiaris (dog)STK11XP_542206.2
Mus musculus (house mouse)Stk11NP_035622.1
Rattus norvegicus (Norway rat)Stk11NP_001101539.1
Gallus gallus (chicken)STK11NP_001039298.1
Danio rerio (zebrafish)stk11NP_001017839.1
Drosophila melanogaster (fruit fly)lkb1NP_731846.1
Caenorhabditis eleganspar-4NP_507533.1
GeneCards STK11
UniProt Q15831
MIM 602216
Ensembl ENSG00000118046
HGNC 11389
HPRD 03740

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
serine/threonine-protein kinase STK11
serine/threonine-protein kinase STK11
liver kinase B1
polarization-related protein LKB1
renal carcinoma antigen NY-REN-19
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1


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