STK11 serine/threonine kinase 11 [Homo sapiens (human)]

Gene Symbol	STK11
Entrez Gene ID	6794
Full Name	serine/threonine kinase 11
Synonyms	LKB1, PJS
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:19 Map Location:19p13.3
Summary	This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq].
Disorder	MIM: 602216 Peutz-Jeghers syndrome, 175200 (3); Melanoma, malignant sporadic (3);

mRNA	NM_000455, 58530881
Protein	NP_000446, 4507271
Product	serine/threonine-protein kinase 11
RefSeq Status	REVIEWED

KEGG

hsa04920	Adipocytokine signaling pathway
hsa04150	mTOR signaling pathway

WikiPathways

WP366

TGF-beta Receptor Signaling Pathway

Pathway Interaction Database

lkb1_pathway

LKB1 signaling events

Reactome

REACT_6838	mTOR signalling
REACT_21285	Regulation of AMPK activity via LKB1
REACT_762	IRS-related events
REACT_1195	Insulin receptor signalling cascade
REACT_1988	AMPK inhibits chREBP transcriptional activation activity
REACT_976	PI3K Cascade
REACT_332	IRS-mediated signalling
REACT_21387	Energy dependent regulation of mTOR by LKB1-AMPK
REACT_1505	Integration of energy metabolism
REACT_498	Signaling by Insulin receptor
REACT_456	PKB-mediated events

Homo sapiens (human)	STK11	NP_000446.1
Pan troglodytes (chimpanzee)	STK11	XP_524028.2
Canis lupus familiaris (dog)	STK11	XP_542206.2
Bos taurus (cattle)	STK11	XP_593229.4
Mus musculus (house mouse)	Stk11	NP_035622.1
Rattus norvegicus (Norway rat)	Stk11	XP_234900.3
Gallus gallus (chicken)	STK11	NP_001039298.1
Danio rerio (zebrafish)	stk11	NP_001017839.1
Danio rerio (zebrafish)	LOC100334053	XP_002661045.1
Drosophila melanogaster (fruit fly)	lkb1	NP_650302.1
Caenorhabditis elegans	par-4	NP_507533.1

Process

ID	Name	Evidence
GO:0001894	tissue homeostasis	IEA
GO:0006112	energy reserve metabolic process	TAS
GO:0006468	protein phosphorylation	IDA
GO:0007049	cell cycle	IEA
GO:0007050	cell cycle arrest	IDA
GO:0007050	cell cycle arrest	TAS
GO:0008285	negative regulation of cell proliferation	IMP
GO:0008286	insulin receptor signaling pathway	TAS
GO:0030111	regulation of Wnt receptor signaling pathway	IEA
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP
GO:0042304	regulation of fatty acid biosynthetic process	TAS
GO:0043276	anoikis	IMP
GO:0046320	regulation of fatty acid oxidation	EXP
GO:0051896	regulation of protein kinase B signaling cascade	IEA
GO:0060070	canonical Wnt receptor signaling pathway	IEA
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	IEA

Component

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0000287	magnesium ion binding	IDA
GO:0004674	protein serine/threonine kinase activity	IDA
GO:0004674	protein serine/threonine kinase activity	TAS
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	IDA
GO:0030275	LRR domain binding	IEA

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

RefSeq Accession	Definition	Sequence	Price	Select
NM_000455	Homo sapiens serine/threonine kinase 11 (STK11), mRNA.	Full Length	$1150.10
NM_000455	Homo sapiens serine/threonine kinase 11 (STK11), mRNA.	ORF Sequence	$377.58