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STK11 serine/threonine kinase 11 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000455 Homo sapiens serine/threonine kinase 11 (STK11), mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
XM_005259617 PREDICTED: Homo sapiens serine/threonine kinase 11 (STK11), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005259618 PREDICTED: Homo sapiens serine/threonine kinase 11 (STK11), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol STK11
Entrez Gene ID 6794
Full Name serine/threonine kinase 11
Synonyms LKB1, PJS, hLKB1
General protein information
Preferred Names
serine/threonine-protein kinase STK11
Names
serine/threonine-protein kinase STK11
liver kinase B1
polarization-related protein LKB1
renal carcinoma antigen NY-REN-19
serine/threonine-protein kinase 11
serine/threonine-protein kinase LKB1
NP_000446.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.3

Summary This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602216

Peutz-Jeghers syndrome, 175200 (3); Melanoma, malignant sporadic (3);

mRNA Protein Product Sequence Price Select
NM_000455, 58530881 NP_000446, 4507271 serine/threonine-protein kinase STK11 ORF Sequence $360.00
XM_005259617, 530425369 XP_005259674, 530425370 serine/threonine-protein kinase STK11 isoform X1 ORF Sequence $700.00
XM_005259618, 578833508 XP_005259675, 530425372 serine/threonine-protein kinase STK11 isoform X2 ORF Sequence $400.00
KEGG
hsa04150mTOR signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04068FoxO signaling pathway
hsa04152AMPK signaling pathway
WikiPathways
WP1984Integrated Breast Cancer Pathway
WP366TGF-beta Receptor Signaling Pathway
WP1403AMPK signaling
WP2377Integrated Pancreatic Cancer Pathway
Pathway Interaction Database
lkb1_pathwayLKB1 signaling events
Reactome
REACT_1988AMPK inhibits chREBP transcriptional activation activity
REACT_1505Integration of energy metabolism
REACT_976PI3K Cascade
REACT_762IRS-related events
REACT_1195Insulin receptor signalling cascade
REACT_498Signaling by Insulin receptor
REACT_332IRS-mediated signalling
REACT_456PKB-mediated events
REACT_6838mTOR signalling
REACT_21387Energy dependent regulation of mTOR by LKB1-AMPK
REACT_21285Regulation of AMPK activity via LKB1
REACT_111217Metabolism
REACT_111102Signal Transduction
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)STK11NP_000446.1
Pan troglodytes (chimpanzee)STK11XP_524028.2
Macaca mulatta (Rhesus monkey)STK11XP_001093806.1
Canis lupus familiaris (dog)STK11XP_542206.2
Mus musculus (house mouse)Stk11NP_035622.1
Rattus norvegicus (Norway rat)Stk11NP_001101539.1
Gallus gallus (chicken)STK11NP_001039298.1
Danio rerio (zebrafish)stk11NP_001017839.1
Caenorhabditis eleganspar-4NP_001256779.1
Xenopus (Silurana) tropicalis (western clawed frog)stk11NP_001016533.1
Process
IDNameEvidence
GO:0001558regulation of cell growthISS
GO:0001894tissue homeostasisIEA
GO:0001944vasculature developmentISS
GO:0006112energy reserve metabolic processTAS
GO:0006468protein phosphorylationIDA
GO:0006914autophagyIEA
GO:0006974cellular response to DNA damage stimulusIEA
GO:0007050cell cycle arrestIDA
GO:0007050cell cycle arrestTAS
GO:0007286spermatid developmentIEA
GO:0007409axonogenesisIEA
GO:0008285negative regulation of cell proliferationIMP
GO:0008286insulin receptor signaling pathwayTAS
GO:0010212response to ionizing radiationISS
GO:0030010establishment of cell polarityISS
GO:0030111regulation of Wnt signaling pathwayIEA
GO:0030308negative regulation of cell growthISS
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0032147activation of protein kinase activityIDA
GO:0032147activation of protein kinase activityIEA
GO:0033762response to glucagonIEA
GO:0033993response to lipidIEA
GO:0036399TCR signalosome assemblyIEA
GO:0042304regulation of fatty acid biosynthetic processTAS
GO:0042593glucose homeostasisISS
GO:0043276anoikisIMP
GO:0044281small molecule metabolic processTAS
GO:0045059positive thymic T cell selectionIEA
GO:0045722positive regulation of gluconeogenesisIEA
GO:0046777protein autophosphorylationIDA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIEA
GO:0050772positive regulation of axonogenesisIEA
GO:0050852T cell receptor signaling pathwayIEA
GO:0051291protein heterooligomerizationIEA
GO:0051645Golgi localizationIEA
GO:0051896regulation of protein kinase B signalingIEA
GO:0060070canonical Wnt signaling pathwayIEA
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland developmentIEA
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediatorIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIDA
GO:0005829cytosolISS
GO:0005829cytosolTAS
GO:0016020membraneISS
GO:0036398TCR signalosomeIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0000287magnesium ion bindingIDA
GO:0002039p53 bindingIDA
GO:0004674protein serine/threonine kinase activityIDA
GO:0004674protein serine/threonine kinase activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIDA
GO:0030275LRR domain bindingIEA
GO:0030295protein kinase activator activityIDA
GO:0032403protein complex bindingIEA
GeneCards STK11
UniProt Q15831
Vega OTTHUMG00000180118
MIM 602216
Ensembl ENSG00000118046
HGNC 11389
HPRD 03740

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the STK11 gene?

The STK11 gene (also called LKB1) provides instructions for making an enzyme called serine/threonine kinase 11. This enzyme is a tumor suppressor, which means that it helps keep cells from growing and dividing too fast or in an uncontrolled way. In addition to its role in regulating cell division, this enzyme helps certain types of cells correctly orient themselves within tissues (polarization) and assists in determining the amount of energy a cell uses. This kinase also promotes a type of programmed cell death known as apoptosis. Through a combination of these mechanisms, serine/threonine kinase 11 aids in the prevention of tumors, especially in the gastrointestinal tract, pancreas, cervix, ovaries, and breasts. Serine/threonine kinase 11 function is also required for normal development before birth.

Interactant

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