BST2 bone marrow stromal cell antigen 2 [Homo sapiens (human)]
| Gene Symbol | BST2 |
| Entrez Gene ID | 684 |
| Full Name | bone marrow stromal cell antigen 2 |
| Synonyms | CD317, TETHERIN |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
19 19p13.1 |
| Summary | Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq]. |
| Disorder | MIM: 600534 |
| mRNA | NM_004335, 7262372 |
| Protein | NP_004326, 4757876 |
| Product | bone marrow stromal antigen 2 precursor |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | BST2 | NP_004326.1 |
| Pan troglodytes (chimpanzee) | BST2 | XP_512491.2 |
| Bos taurus (cattle) | BST2 | XP_876152.2 |
| Bos taurus (cattle) | BST2 | XP_584000.2 |
| Mus musculus (house mouse) | Bst2 | NP_932763.1 |
| Rattus norvegicus (Norway rat) | Bst2 | NP_937767.1 |
| ID | Name | Evidence |
| GO:0006959 | humoral immune response | TAS |
| GO:0007165 | signal transduction | IMP |
| GO:0007267 | cell-cell signaling | TAS |
| GO:0007275 | multicellular organismal development | TAS |
| GO:0008283 | cell proliferation | TAS |
| GO:0042113 | B cell activation | IEA |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB cascade | IMP |
| GO:0045087 | innate immune response | IEA |
| GO:0051607 | defense response to virus | IDA |
Component
| ID | Name | Evidence |
| GO:0005770 | late endosome | IEA |
| GO:0005794 | Golgi apparatus | IEA |
| GO:0005887 | integral to plasma membrane | TAS |
| GO:0031225 | anchored to membrane | IEA |
| GO:0044459 | plasma membrane part | IDA |
Function
| ID | Name | Evidence |
| GO:0004871 | signal transducer activity | IMP |
| GO:0042803 | protein homodimerization activity | IPI |
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