T T, brachyury homolog (mouse) [Homo sapiens (human)]

Gene Symbol	T
Entrez Gene ID	6862
Full Name	T, brachyury homolog (mouse)
Synonyms	MGC104817, TFT
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:6 Map Location:6q27
Summary	The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq].
Disorder	MIM: 601397 {Neural tube defects, susceptibility to}, 182940 (3)

Pathway Interaction Database

wnt_beta_catenin_pathway

Regulation of Wnt-mediated beta catenin signaling and target gene transcription

Homo sapiens (human)	T	NP_003172.1
Pan troglodytes (chimpanzee)	T	XP_527563.2
Canis lupus familiaris (dog)	T	NP_001003092.1
Bos taurus (cattle)	T	XP_869983.2
Mus musculus (house mouse)	T	NP_033335.1
Rattus norvegicus (Norway rat)	T	XP_217890.3
Gallus gallus (chicken)	T	NP_990271.1
Danio rerio (zebrafish)	LOC100004296	XP_001343633.2
Drosophila melanogaster (fruit fly)	byn	NP_524031.1

Process

ID	Name	Evidence
GO:0001570	vasculogenesis	IEA
GO:0001756	somitogenesis	IEA
GO:0001839	neural plate morphogenesis	IEA
GO:0001843	neural tube closure	IEA
GO:0006351	transcription, DNA-dependent	NAS
GO:0006355	regulation of transcription, DNA-dependent	IEA
GO:0007165	signal transduction	NAS
GO:0007275	multicellular organismal development	IEA
GO:0007498	mesoderm development	TAS
GO:0008284	positive regulation of cell proliferation	IEA
GO:0008595	anterior/posterior axis specification, embryo	TAS
GO:0022414	reproductive process	IEA
GO:0030903	notochord development	IEA
GO:0035121	tail morphogenesis	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA
GO:0060395	SMAD protein signal transduction	IEA
GO:0090009	primitive streak formation	NAS

Component

Function

ID	Name	Evidence
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA
GO:0043565	sequence-specific DNA binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_003181	Homo sapiens T, brachyury homolog (mouse) (T), mRNA.	Full Length	$730.22
NM_003181	Homo sapiens T, brachyury homolog (mouse) (T), mRNA.	ORF Sequence	$379.32