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T T, brachyury homolog (mouse) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu17741 NM_003181 Homo sapiens T, brachyury homolog (mouse) (T), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu17747 NM_001270484 Homo sapiens T, brachyury homolog (mouse) (T), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu17741C NM_003181 Homo sapiens T, brachyury homolog (mouse) (T), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu17747C NM_001270484 Homo sapiens T, brachyury homolog (mouse) (T), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol T
Entrez Gene ID 6862
Full Name T, brachyury homolog (mouse)
Synonyms SAVA, TFT
General protein information
Preferred Names
brachyury protein
Names
brachyury protein
protein T
T brachyury homolog
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6q27

Summary The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].
Disorder

MIM: 601397

{Neural tube defects, susceptibility to}, 182940 (3)

mRNA Protein Product Sequence Price Select
NM_001270484, 394953946 NP_001257413, 394953947 brachyury protein isoform 2 ORF Sequence $400.00
NM_003181, 394953944 NP_003172, 4507339 brachyury protein isoform 1 ORF Sequence $360.00
WikiPathways
WP2406Cardiac Progenitor Differentiation
Pathway Interaction Database
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
BIOCYC
HUMAN_GLYCLEAV-PWYglycine cleavage
Homo sapiens (human)TNP_003172.1
Pan troglodytes (chimpanzee)TXP_527563.3
Macaca mulatta (Rhesus monkey)TXP_001101514.1
Canis lupus familiaris (dog)TNP_001003092.1
Bos taurus (cattle)TNP_001179914.1
Mus musculus (house mouse)TNP_033335.1
Rattus norvegicus (Norway rat)TNP_001099679.1
Gallus gallus (chicken)TNP_990271.1
Danio rerio (zebrafish)LOC100004296XP_001343633.3
Xenopus (Silurana) tropicalis (western clawed frog)tNP_001008139.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterISS
GO:0001570vasculogenesisIEA
GO:0001756somitogenesisIEA
GO:0001839neural plate morphogenesisIEA
GO:0001843neural tube closureIEA
GO:0003007heart morphogenesisIDA
GO:0003257positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiationIDA
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0007165signal transductionNAS
GO:0007341penetration of zona pellucidaIEA
GO:0007498mesoderm developmentTAS
GO:0007509mesoderm migration involved in gastrulationIEA
GO:0008284positive regulation of cell proliferationIEA
GO:0008595anterior/posterior axis specification, embryoTAS
GO:0014028notochord formationIEA
GO:0023019signal transduction involved in regulation of gene expressionIEA
GO:0030509BMP signaling pathwayIEA
GO:0036342post-anal tail morphogenesisIEA
GO:0048706embryonic skeletal system developmentIEA
GO:0060070canonical Wnt signaling pathwayIEA
GO:0060349bone morphogenesisIEA
GO:0060395SMAD protein signal transductionIEA
GO:0061371determination of heart left/right asymmetryIEA
GO:0090009primitive streak formationNAS
Component
IDNameEvidence
GO:0000790nuclear chromatinIDA
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISS
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIDA
GO:0001085RNA polymerase II transcription factor bindingISS
GO:0001102RNA polymerase II activating transcription factor bindingIPI
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionISS
GO:0003700sequence-specific DNA binding transcription factor activityNAS
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIDA
GeneCards T
UniProt O15178
Vega OTTHUMG00000015991
MIM 601397
Ensembl ENSG00000164458
HGNC 11515
HPRD 03236

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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