ADAM17 ADAM metallopeptidase domain 17 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	ADAM17
Entrez Gene ID	6868
Full Name	ADAM metallopeptidase domain 17
Synonyms	ADAM18, CD156B, CSVP, MGC71942, TACE
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:2 Map Location:2p25
Summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].
Disorder	MIM: 603639

mRNA	NM_003183, 73747888
Protein	NP_003174, 73747889
Product	disintegrin and metalloproteinase domain-containing protein 17 preproprotein
RefSeq Status	REVIEWED

KEGG

hsa04330	Notch signaling pathway
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05010	Alzheimer's disease

WikiPathways

WP61	Delta-Notch Signaling Pathway

Pathway Interaction Database

tnfpathway	TNF receptor signaling pathway
erbb4_pathway	ErbB4 signaling events
p75ntrpathway	p75(NTR)-mediated signaling

Reactome

REACT_11061	Signalling by NGF
REACT_9417	Signaling by EGFR
REACT_13776	p75 NTR receptor-mediated signalling
REACT_13443	Regulated proteolysis of p75NTR

Homo sapiens (human)	ADAM17	NP_003174.3
Pan troglodytes (chimpanzee)	ADAM17	XP_515293.2
Bos taurus (cattle)	ADAM17	XP_595713.2
Mus musculus (house mouse)	Adam17	NP_033745.4
Rattus norvegicus (Norway rat)	Adam17	NP_064702.1
Gallus gallus (chicken)	ADAM17	NP_001008682.1
Danio rerio (zebrafish)	adam17a	NP_955967.1
Danio rerio (zebrafish)	adam17b	XP_689147.1
Drosophila melanogaster (fruit fly)	Tace	NP_733334.1
Caenorhabditis elegans	adm-4	NP_509318.1

Process

ID	Name	Evidence
GO:0001666	response to hypoxia	IDA
GO:0001934	positive regulation of protein phosphorylation	IMP
GO:0002446	neutrophil mediated immunity	IC
GO:0002467	germinal center formation	ISS
GO:0002690	positive regulation of leukocyte chemotaxis	IC
GO:0006508	proteolysis	IEA
GO:0006509	membrane protein ectodomain proteolysis	IDA
GO:0006509	membrane protein ectodomain proteolysis	IMP
GO:0006916	anti-apoptosis	IEA
GO:0007155	cell adhesion	IDA
GO:0007173	epidermal growth factor receptor signaling pathway	IDA
GO:0007173	epidermal growth factor receptor signaling pathway	TAS
GO:0007219	Notch signaling pathway	IEA
GO:0008284	positive regulation of cell proliferation	IMP
GO:0010820	positive regulation of T cell chemotaxis	IMP
GO:0030183	B cell differentiation	ISS
GO:0030307	positive regulation of cell growth	IMP
GO:0030335	positive regulation of cell migration	IMP
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0031293	membrane protein intracellular domain proteolysis	EXP
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S	IDA
GO:0032496	response to lipopolysaccharide	IDA
GO:0032717	negative regulation of interleukin-8 production	IMP
GO:0032722	positive regulation of chemokine production	IMP
GO:0033025	regulation of mast cell apoptosis	ISS
GO:0033077	T cell differentiation in thymus	ISS
GO:0033627	cell adhesion mediated by integrin	IDA
GO:0035313	wound healing, spreading of epidermal cells	IEP
GO:0035625	epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway	IMP
GO:0042493	response to drug	ISS
GO:0045741	positive regulation of epidermal growth factor receptor activity	IDA
GO:0045741	positive regulation of epidermal growth factor receptor activity	IMP
GO:0048011	nerve growth factor receptor signaling pathway	TAS
GO:0048536	spleen development	ISS
GO:0048870	cell motility	ISS
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	IDA
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis	IMP
GO:0051272	positive regulation of cellular component movement	ISS
GO:0055099	response to high density lipoprotein particle stimulus	IDA

Component

ID	Name	Evidence
GO:0005737	cytoplasm	IDA
GO:0005886	plasma membrane	TAS
GO:0005887	integral to plasma membrane	IDA
GO:0005911	cell-cell junction	IDA
GO:0005925	focal adhesion	IDA
GO:0009986	cell surface	IDA
GO:0015629	actin cytoskeleton	IDA
GO:0016324	apical plasma membrane	IDA
GO:0032587	ruffle membrane	IDA
GO:0045121	membrane raft	IDA

Function

ID	Name	Evidence
GO:0004222	metalloendopeptidase activity	IDA
GO:0004222	metalloendopeptidase activity	IMP
GO:0005138	interleukin-6 receptor binding	IPI
GO:0005178	integrin binding	IPI
GO:0005515	protein binding	IPI
GO:0008233	peptidase activity	IEA
GO:0008237	metallopeptidase activity	IDA
GO:0008237	metallopeptidase activity	IMP
GO:0008237	metallopeptidase activity	TAS
GO:0008270	zinc ion binding	IEA
GO:0017124	SH3 domain binding	IEA
GO:0030165	PDZ domain binding	IPI
GO:0046872	metal ion binding	IEA

GeneCards	ADAM17
PDB	2I47, 1ZXC, 3LGP, 3E8R, 3EDZ, 3B92, 3KMC, 3LEA, 2DDF, 2A8H, 3L0V, 2OI0, 3LE9, 1BKC, 3L0T, 2FV9, 3CKI, 3G42, 2FV5, 3KME, 3EWJ
UniProt	B2RNB2, P78536
MIM	603639
Ensembl	ENSG00000151694
HGNC	195
HPRD	04703

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RefSeq Accession	Definition	Sequence	Price	Select
NM_003183	Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), mRNA.	Full Length	$1250.20
NM_003183		ORF Sequence	$717.75