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ADAM17 ADAM metallopeptidase domain 17 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_003183 Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), mRNA. ORF Sequence $717.75
Peptide Services
Antibody Services
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Gene Symbol ADAM17
Entrez Gene ID 6868
Full Name ADAM metallopeptidase domain 17
Synonyms ADAM18, CD156B, CSVP, MGC71942, TACE
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p25

Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603639

mRNA Protein Product Sequence Price Select
NM_003183, 73747888 NP_003174, 73747889 disintegrin and metalloproteinase domain-containing protein 17 preproprotein Full Length $1250.20
ORF Sequence $717.75
KEGG
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04330Notch signaling pathway
hsa05010Alzheimer's disease
WikiPathways
WP61Delta-Notch Signaling Pathway
WP268Notch Signaling Pathway
WP2059Alzheimers Disease
Pathway Interaction Database
tnfpathwayTNF receptor signaling pathway
erbb4_pathwayErbB4 signaling events
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_116022Nuclear signaling by ERBB4
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_299Signaling by NOTCH
REACT_75790Cytokine Signaling in Immune system
REACT_118859Signaling by NOTCH1
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_13776p75 NTR receptor-mediated signalling
REACT_9417Signaling by EGFR
REACT_111133Growth hormone receptor signaling
REACT_13443Regulated proteolysis of p75NTR
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_6900Immune System
Homo sapiens (human)ADAM17NP_003174.3
Pan troglodytes (chimpanzee)ADAM17XP_515293.2
Macaca mulatta (Rhesus monkey)ADAM17XP_002799185.1
Canis lupus familiaris (dog)ADAM17XP_532870.4
Bos taurus (cattle)ADAM17XP_002691532.1
Mus musculus (house mouse)Adam17NP_033745.4
Rattus norvegicus (Norway rat)Adam17NP_064702.1
Gallus gallus (chicken)ADAM17NP_001008682.1
Danio rerio (zebrafish)adam17bXP_689147.2
Danio rerio (zebrafish)adam17aNP_955967.1
Drosophila melanogaster (fruit fly)TaceNP_733334.1
Caenorhabditis elegansadm-4NP_509318.1
GeneCards ADAM17
PDB 2I47, 1ZXC, 3LGP, 3E8R, 3EDZ, 3B92, 3O64, 3KMC, 3LEA, 2DDF, 2A8H, 3L0V, 2OI0, 3LE9, 1BKC, 3L0T, 2FV9, 3CKI, 3G42, 2FV5, 3KME, 3EWJ
UniProt B2RNB2, P78536
MIM 603639
Ensembl ENSG00000151694
HGNC 195
HPRD 04703

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 17
Names
disintegrin and metalloproteinase domain-containing protein 17
TNF-alpha convertase
snake venom-like protease
TNF-alpha converting enzyme
ADAM metallopeptidase domain 18
tumor necrosis factor, alpha, converting enzyme
NP_003174.3

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