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ADAM17 ADAM metallopeptidase domain 17 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu21940 NM_003183 Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu21940C NM_003183 Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol ADAM17
Entrez Gene ID 6868
Full Name ADAM metallopeptidase domain 17
Synonyms ADAM18, CD156B, CSVP, NISBD, TACE
General protein information
Preferred Names
disintegrin and metalloproteinase domain-containing protein 17
Names
disintegrin and metalloproteinase domain-containing protein 17
TNF-alpha convertase
snake venom-like protease
TNF-alpha converting enzyme
ADAM metallopeptidase domain 18
tumor necrosis factor, alpha, converting enzyme
NP_003174.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p25

Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008].
Disorder

MIM: 603639

mRNA Protein Product Sequence Price Select
NM_003183, 73747888 NP_003174, 73747889 disintegrin and metalloproteinase domain-containing protein 17 preproprotein ORF Sequence $750.00
KEGG
hsa04330Notch signaling pathway
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05010Alzheimer's disease
WikiPathways
WP61Delta-Notch Signaling Pathway
WP268Notch Signaling Pathway
WP2380BDNF signaling pathway
WP2059Alzheimers Disease
Pathway Interaction Database
erbb4_pathwayErbB4 signaling events
tnfpathwayTNF receptor signaling pathway
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_578Apoptosis
REACT_1059Extrinsic Pathway for Apoptosis
REACT_1619Death Receptor Signalling
REACT_1432TNF signaling
REACT_9417Signaling by EGFR
REACT_6900Immune System
REACT_13443Regulated proteolysis of p75NTR
REACT_11061Signalling by NGF
REACT_13776p75 NTR receptor-mediated signalling
REACT_299Signaling by NOTCH
REACT_75790Cytokine Signaling in Immune system
REACT_111133Growth hormone receptor signaling
REACT_111102Signal Transduction
REACT_116125Disease
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_116022Nuclear signaling by ERBB4
REACT_118572Degradation of the extracellular matrix
REACT_118859Signaling by NOTCH1
REACT_118779Extracellular matrix organization
REACT_118614Activated NOTCH1 Transmits Signal to the Nucleus
REACT_150401Collagen degradation
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160106Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_160089Constitutive Signaling by NOTCH1 HD Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
Homo sapiens (human)ADAM17NP_003174.3
Pan troglodytes (chimpanzee)ADAM17XP_515293.2
Macaca mulatta (Rhesus monkey)ADAM17XP_002799185.1
Canis lupus familiaris (dog)ADAM17XP_005630166.1
Bos taurus (cattle)ADAM17XP_002691532.1
Mus musculus (house mouse)Adam17NP_033745.4
Rattus norvegicus (Norway rat)Adam17NP_064702.1
Gallus gallus (chicken)ADAM17NP_001008682.1
Danio rerio (zebrafish)adam17aNP_955967.1
Danio rerio (zebrafish)adam17bXP_689147.3
Drosophila melanogaster (fruit fly)TaceNP_733334.1
Caenorhabditis elegansadm-4NP_509318.1
Xenopus (Silurana) tropicalis (western clawed frog)adam17NP_001182159.1
Process
IDNameEvidence
GO:0001666response to hypoxiaIDA
GO:0001934positive regulation of protein phosphorylationIMP
GO:0002446neutrophil mediated immunityIC
GO:0002467germinal center formationISS
GO:0002690positive regulation of leukocyte chemotaxisIC
GO:0006508proteolysisIDA
GO:0006509membrane protein ectodomain proteolysisIDA
GO:0006509membrane protein ectodomain proteolysisIMP
GO:0006915apoptotic processTAS
GO:0007155cell adhesionIDA
GO:0007173epidermal growth factor receptor signaling pathwayIDA
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007219Notch signaling pathwayIEA
GO:0007220Notch receptor processingIDA
GO:0008284positive regulation of cell proliferationIMP
GO:0010820positive regulation of T cell chemotaxisIMP
GO:0022617extracellular matrix disassemblyTAS
GO:0030183B cell differentiationISS
GO:0030198extracellular matrix organizationTAS
GO:0030307positive regulation of cell growthIMP
GO:0030335positive regulation of cell migrationIMP
GO:0030511positive regulation of transforming growth factor beta receptor signaling pathwayISS
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayIMP
GO:0030574collagen catabolic processTAS
GO:0031293membrane protein intracellular domain proteolysisTAS
GO:0031659positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycleIDA
GO:0032496response to lipopolysaccharideIDA
GO:0032717negative regulation of interleukin-8 productionIMP
GO:0032722positive regulation of chemokine productionIMP
GO:0033025regulation of mast cell apoptotic processISS
GO:0033077T cell differentiation in thymusISS
GO:0033627cell adhesion mediated by integrinIDA
GO:0035313wound healing, spreading of epidermal cellsIEP
GO:0035625epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayIMP
GO:0042493response to drugISS
GO:0045741positive regulation of epidermal growth factor-activated receptor activityIDA
GO:0045741positive regulation of epidermal growth factor-activated receptor activityIMP
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048536spleen developmentISS
GO:0048870cell motilityISS
GO:0051088PMA-inducible membrane protein ectodomain proteolysisIDA
GO:0051088PMA-inducible membrane protein ectodomain proteolysisIMP
GO:0051272positive regulation of cellular component movementISS
GO:0055099response to high density lipoprotein particleIDA
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayTAS
GO:0097190apoptotic signaling pathwayTAS
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneIDA
GO:0005911cell-cell junctionIDA
GO:0005925focal adhesionIDA
GO:0009986cell surfaceIDA
GO:0015629actin cytoskeletonIDA
GO:0016020membraneIDA
GO:0016324apical plasma membraneIDA
GO:0032587ruffle membraneIDA
GO:0045121membrane raftIDA
Function
IDNameEvidence
GO:0004222metalloendopeptidase activityIDA
GO:0004222metalloendopeptidase activityIMP
GO:0004222metalloendopeptidase activityTAS
GO:0005112Notch bindingIDA
GO:0005138interleukin-6 receptor bindingIPI
GO:0005178integrin bindingIPI
GO:0005515protein bindingIPI
GO:0008237metallopeptidase activityIDA
GO:0008237metallopeptidase activityIMP
GO:0008237metallopeptidase activityTAS
GO:0008270zinc ion bindingIEA
GO:0017124SH3 domain bindingIEA
GO:0030165PDZ domain bindingIPI
GeneCards ADAM17
UniProt B2RNB2, P78536
Vega OTTHUMG00000090425
MIM 603639
Ensembl ENSG00000151694
HGNC 195
HPRD 04703

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