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TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_003185 Homo sapiens TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa (TAF4), mRNA. Full Length $1626.45
ORF Sequence $1140.30


Gene Symbol TAF4
Entrez Gene ID 6874
Full Name TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
Synonyms FLJ41943, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

20

20q13.33
Summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq].
Disorder

MIM: 601796
mRNA NM_003185, 110832842
Protein NP_003176, 110832843
Product transcription initiation factor TFIID subunit 4
RefSeq Status REVIEWED
KEGG
hsa03022Basal transcription factors
hsa05016Huntington's disease
Reactome
REACT_1851RNA Polymerase II Transcription Initiation
REACT_2039Formation and Maturation of mRNA Transcript
REACT_1366RNA Polymerase II Transcription
REACT_6185HIV Infection
REACT_834RNA Polymerase II Transcription Initiation And Promoter Clearance
REACT_6253RNA Polymerase II HIV-1 Promoter Escape
REACT_1788Transcription
REACT_6361Late Phase of HIV Life Cycle
REACT_22107RNA Polymerase II Pre-transcription Events
REACT_71Gene Expression
REACT_2089RNA Polymerase II Promoter Escape
REACT_6233Transcription of the HIV genome
REACT_6256HIV Life Cycle
REACT_1655RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REACT_6332HIV-1 Transcription Initiation
Homo sapiens (human)TAF4NP_003176.2
Pan troglodytes (chimpanzee)TAF4XP_514759.2
Canis lupus familiaris (dog)TAF4XP_534471.2
Bos taurus (cattle)TAF4XP_001787979.1
Mus musculus (house mouse)Taf4aNP_001074561.1
Gallus gallus (chicken)TAF4XP_417400.2
Danio rerio (zebrafish)LOC100149942XP_001920944.1
Process
IDNameEvidence
GO:0001541ovarian follicle developmentIEA
GO:0006357regulation of transcription from RNA polymerase II promoterIEA
GO:0006366transcription from RNA polymerase II promoterTAS
GO:0006367transcription initiation from RNA polymerase II promoterEXP
GO:0006367transcription initiation from RNA polymerase II promoterIDA
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0006368transcription elongation from RNA polymerase II promoterEXP
GO:0010467gene expressionTAS
GO:0016032viral reproductionTAS
GO:0044419interspecies interaction between organismsIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmEXP
GO:0005654nucleoplasmTAS
GO:0005669transcription factor TFIID complexIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0033276transcription factor TFTC complexIDA
GO:0071339MLL1 complexIDA
Function
IDNameEvidence
GO:0003677DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003713transcription coactivator activityTAS
GO:0005515protein bindingIPI
GeneCards TAF4
PDB 2P6V, 1H3O
UniProt O00268
MIM 601796
Ensembl ENSG00000130699
HGNC 11537
HPRD 11797

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