• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


TBX1 T-box 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19922 NM_080647 Homo sapiens T-box 1 (TBX1), transcript variant C, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu19962 NM_080646 Homo sapiens T-box 1 (TBX1), transcript variant A, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20328 NM_005992 Homo sapiens T-box 1 (TBX1), transcript variant B, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu53673 XM_005261269 PREDICTED: Homo sapiens T-box 1 (TBX1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu19922 XM_006724312 PREDICTED: Homo sapiens T-box 1 (TBX1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu19922C NM_080647 Homo sapiens T-box 1 (TBX1), transcript variant C, mRNA. Customized vector On-demand 7-9 $269.00
OHu19962C NM_080646 Homo sapiens T-box 1 (TBX1), transcript variant A, mRNA. Customized vector On-demand 7-9 $269.00
OHu20328C NM_005992 Homo sapiens T-box 1 (TBX1), transcript variant B, mRNA. Customized vector On-demand 7-9 $269.00
OHu53673C XM_005261269 PREDICTED: Homo sapiens T-box 1 (TBX1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00
OHu19922C XM_006724312 PREDICTED: Homo sapiens T-box 1 (TBX1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $269.00

*Business Day

Related Services

Gene Symbol TBX1
Entrez Gene ID 6899
Full Name T-box 1
Synonyms CAFS, CATCH22, CTHM, DGCR, DGS, DORV, TBX1C, TGA, VCF, VCFS
General protein information
Preferred Names
T-box transcription factor TBX1
Names
T-box transcription factor TBX1
brachyury
Testis-specific T-box protein
T-box 1 transcription factor C
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q11.21

Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602054

Conotruncal anomaly face syndrome, 217095 (3); DiGeorge syndrome,

mRNA Protein Product Sequence Price Select
NM_005992, 5174710 NP_005983, 5174711 T-box transcription factor TBX1 isoform B ORF Sequence $400.00
NM_080646, 18104949 NP_542377, 18104950 T-box transcription factor TBX1 isoform A ORF Sequence $400.00
NM_080647, 18104951 NP_542378, 18104952 T-box transcription factor TBX1 isoform C ORF Sequence $550.00
XM_005261269, 530426269 XP_005261326, 530426270 T-box transcription factor TBX1 isoform X1 ORF Sequence $550.00
XM_006724312, 578837372 XP_006724375, 578837373 T-box transcription factor TBX1 isoform X2 ORF Sequence $550.00
WikiPathways
WP1591Heart Development
Homo sapiens (human)TBX1NP_542378.1
Pan troglodytes (chimpanzee)TBX1XP_514982.3
Macaca mulatta (Rhesus monkey)LOC100429202XP_002798308.1
Canis lupus familiaris (dog)TBX1XP_850266.3
Mus musculus (house mouse)Tbx1NP_035662.1
Rattus norvegicus (Norway rat)Tbx1NP_001101792.1
Danio rerio (zebrafish)tbx1NP_899182.1
Caenorhabditis elegansmls-1NP_498640.1
Xenopus (Silurana) tropicalis (western clawed frog)tbx1NP_001030290.1
Process
IDNameEvidence
GO:0001525angiogenesisISS
GO:0001568blood vessel developmentISS
GO:0001708cell fate specificationISS
GO:0001755neural crest cell migrationISS
GO:0001934positive regulation of protein phosphorylationISS
GO:0001945lymph vessel developmentISS
GO:0001974blood vessel remodelingIEA
GO:0002053positive regulation of mesenchymal cell proliferationISS
GO:0003007heart morphogenesisISS
GO:0003148outflow tract septum morphogenesisISS
GO:0003151outflow tract morphogenesisISS
GO:0006351transcription, DNA-templatedIEA
GO:0006357regulation of transcription from RNA polymerase II promoterISS
GO:0006357regulation of transcription from RNA polymerase II promoterNAS
GO:0007368determination of left/right symmetryISS
GO:0007389pattern specification processISS
GO:0007498mesoderm developmentISS
GO:0007507heart developmentIMP
GO:0007517muscle organ developmentISS
GO:0007605sensory perception of soundISS
GO:0008283cell proliferationISS
GO:0008284positive regulation of cell proliferationISS
GO:0009952anterior/posterior pattern specificationISS
GO:0021644vagus nerve morphogenesisISS
GO:0030855epithelial cell differentiationISS
GO:0030878thyroid gland developmentISS
GO:0035176social behaviorISS
GO:0035909aorta morphogenesisISS
GO:0042471ear morphogenesisISS
GO:0042472inner ear morphogenesisISS
GO:0042473outer ear morphogenesisISS
GO:0042474middle ear morphogenesisISS
GO:0042475odontogenesis of dentin-containing toothISS
GO:0042693muscle cell fate commitmentISS
GO:0043410positive regulation of MAPK cascadeISS
GO:0043587tongue morphogenesisISS
GO:0044344cellular response to fibroblast growth factor stimulusISS
GO:0045596negative regulation of cell differentiationISS
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0048384retinoic acid receptor signaling pathwayISS
GO:0048514blood vessel morphogenesisISS
GO:0048538thymus developmentIMP
GO:0048644muscle organ morphogenesisISS
GO:0048701embryonic cranial skeleton morphogenesisISS
GO:0048703embryonic viscerocranium morphogenesisIMP
GO:0048752semicircular canal morphogenesisISS
GO:0048844artery morphogenesisISS
GO:0050679positive regulation of epithelial cell proliferationISS
GO:0060017parathyroid gland developmentIMP
GO:0060023soft palate developmentIMP
GO:0060037pharyngeal system developmentIMP
GO:0060325face morphogenesisISS
GO:0060415muscle tissue morphogenesisISS
GO:0060982coronary artery morphogenesisISS
GO:0070166enamel mineralizationISS
GO:0071300cellular response to retinoic acidISS
GO:0071600otic vesicle morphogenesisIEA
GO:0072513positive regulation of secondary heart field cardioblast proliferationIEA
GO:0090103cochlea morphogenesisISS
GO:0097152mesenchymal cell apoptotic processISS
GO:2000027regulation of organ morphogenesisISS
GO:2001037positive regulation of tongue muscle cell differentiationISS
GO:2001054negative regulation of mesenchymal cell apoptotic processISS
Component
IDNameEvidence
GO:0005634nucleusIDA
Function
IDNameEvidence
GO:0003677DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0042803protein homodimerization activityIDA
GO:0043565sequence-specific DNA bindingIDA
GO:0046983protein dimerization activityTAS
GeneCards TBX1
UniProt O43435, Q152R5, D9ZGG0
Vega OTTHUMG00000150421
MIM 602054
Ensembl ENSG00000184058
HGNC 11592
HPRD 09069

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.