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TBX5 T-box 5 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20722 NM_000192 Homo sapiens T-box 5 (TBX5), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu20722 NM_181486 Homo sapiens T-box 5 (TBX5), transcript variant 4, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu21706 NM_080717 Homo sapiens T-box 5 (TBX5), transcript variant 3, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu46824 XM_006719582 PREDICTED: Homo sapiens T-box 5 (TBX5), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20722C NM_000192 Homo sapiens T-box 5 (TBX5), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu20722C NM_181486 Homo sapiens T-box 5 (TBX5), transcript variant 4, mRNA. Customized vector In-stock 5-7 $149.00
OHu21706C NM_080717 Homo sapiens T-box 5 (TBX5), transcript variant 3, mRNA. Customized vector In-stock 5-7 $149.00
OHu46824C XM_006719582 PREDICTED: Homo sapiens T-box 5 (TBX5), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol TBX5
Entrez Gene ID 6910
Full Name T-box 5
Synonyms HOS
General protein information
Preferred Names
T-box transcription factor TBX5
Names
T-box transcription factor TBX5
T-box protein 5
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.1

Summary This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601620

Holt-Oram syndrome, 142900 (3)

mRNA Protein Product Sequence Price Select
NM_000192, 31652233 NP_000183, 18201892 T-box transcription factor TBX5 isoform 1 ORF Sequence $360.00
NM_080717, 31652234 NP_542448, 18201894 T-box transcription factor TBX5 isoform 3 ORF Sequence $360.00
NM_181486, 387527994 NP_852259, 31652232 T-box transcription factor TBX5 isoform 1 ORF Sequence $360.00
XM_006719582, 578824185 XP_006719645, 578824186 T-box transcription factor TBX5 isoform X1 ORF Sequence $400.00
WikiPathways
WP1591Heart Development
WP2406Cardiac Progenitor Differentiation
Reactome
REACT_12627Generic Transcription Pathway
REACT_71Gene Expression
REACT_118713YAP1- and WWTR1 (TAZ)-stimulated gene expression
Homo sapiens (human)TBX5NP_000183.2
Pan troglodytes (chimpanzee)TBX5XP_001154140.2
Macaca mulatta (Rhesus monkey)TBX5XP_001111737.1
Canis lupus familiaris (dog)TBX5XP_005636327.1
Bos taurus (cattle)TBX5NP_001179678.1
Mus musculus (house mouse)Tbx5NP_035667.1
Rattus norvegicus (Norway rat)Tbx5NP_001009964.1
Gallus gallus (chicken)TBX5NP_989504.1
Danio rerio (zebrafish)tbx5aNP_570990.1
Xenopus (Silurana) tropicalis (western clawed frog)tbx5NP_001185697.1
Process
IDNameEvidence
GO:0002009morphogenesis of an epitheliumIEA
GO:0003166bundle of His developmentIEA
GO:0003181atrioventricular valve morphogenesisIEA
GO:0003197endocardial cushion developmentIEA
GO:0003218cardiac left ventricle formationISS
GO:0003229ventricular cardiac muscle tissue developmentIEA
GO:0003281ventricular septum developmentISS
GO:0006367transcription initiation from RNA polymerase II promoterTAS
GO:0007267cell-cell signalingIDA
GO:0007389pattern specification processIEA
GO:0007507heart developmentIDA
GO:0007507heart developmentIMP
GO:0008285negative regulation of cell proliferationIDA
GO:0010467gene expressionTAS
GO:0010719negative regulation of epithelial to mesenchymal transitionTAS
GO:0030262apoptotic nuclear changesIDA
GO:0030324lung developmentIEA
GO:0030326embryonic limb morphogenesisIMP
GO:0030336negative regulation of cell migrationIDA
GO:0035115embryonic forelimb morphogenesisIMP
GO:0035136forelimb morphogenesisIMP
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0051891positive regulation of cardioblast differentiationIDA
GO:0055007cardiac muscle cell differentiationIEA
GO:0060039pericardium developmentIDA
GO:0060044negative regulation of cardiac muscle cell proliferationIDA
GO:0060045positive regulation of cardiac muscle cell proliferationIEA
GO:0060413atrial septum morphogenesisIEA
GO:0060980cell migration involved in coronary vasculogenesisTAS
GO:0072513positive regulation of secondary heart field cardioblast proliferationIEA
GO:1900117regulation of execution phase of apoptosisIC
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005654nucleoplasmTAS
GO:0005667transcription factor complexIEA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmTAS
Function
IDNameEvidence
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIEA
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEA
GO:0003677DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityIMP
GO:0005515protein bindingIPI
GO:0008134transcription factor bindingIPI
GO:0043565sequence-specific DNA bindingIDA
GeneCards TBX5
UniProt Q99593
Vega OTTHUMG00000166191
MIM 601620
Ensembl ENSG00000089225
HGNC 11604
HPRD 03372

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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