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TBXAS1 thromboxane A synthase 1 (platelet) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001061 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mRNA. ORF Sequence $465.45
Peptide Services
Antibody Services
Protein Services
NM_001130966 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 3, mRNA. ORF Sequence $465.45
Peptide Services
Antibody Services
Protein Services
NM_001166253 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA. ORF Sequence $505.47
Peptide Services
Antibody Services
Protein Services
NM_001166254 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 5, mRNA. ORF Sequence $406.29
Peptide Services
Antibody Services
Protein Services
NM_030984 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 2, mRNA. ORF Sequence $401.07
Peptide Services
Antibody Services
Protein Services


Gene Symbol TBXAS1
Entrez Gene ID 6916
Full Name thromboxane A synthase 1 (platelet)
Synonyms CYP5, CYP5A1, FLJ52771, GHOSAL, THAS, TS, TXAS, TXS
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q34-q35

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Disorder

MIM: 274180

Thromboxane synthase deficiency (2); Ghosal syndrome, 231095 (3)

mRNA Protein Product Sequence Price Select
NM_001061, 261278363 NP_001052, 195972898 thromboxane-A synthase isoform 1 Full Length $603.78
ORF Sequence $465.45
NM_001130966, 261278366 NP_001124438, 195972896 thromboxane-A synthase isoform 1 Full Length $691.65
ORF Sequence $465.45
NM_001166253, 261278369 NP_001159725, 261278370 thromboxane-A synthase isoform 3 Full Length $643.80
ORF Sequence $505.47
NM_001166254, 261278371 NP_001159726, 261278372 thromboxane-A synthase isoform 4 Full Length $618.28
ORF Sequence $406.29
NM_030984, 261278364 NP_112246, 195972900 thromboxane-A synthase isoform 2 Full Length $556.51
ORF Sequence $401.07
KEGG
hsa00590Arachidonic acid metabolism
WikiPathways
WP98Prostaglandin Synthesis and Regulation
WP167Eicosanoid Synthesis
BIOCYC
HUMAN_PWY66-374prostanoid biosynthesis
Reactome
REACT_13433Biological oxidations
REACT_22258Metabolism of lipids and lipoproteins
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13645Eicosanoids
REACT_111217Metabolism
REACT_147851Arachidonic acid metabolism
REACT_13705Phase 1 - Functionalization of compounds
Homo sapiens (human)TBXAS1NP_001159725.1
Pan troglodytes (chimpanzee)TBXAS1XP_001152761.1
Macaca mulatta (Rhesus monkey)TBXAS1XP_002803529.1
Canis lupus familiaris (dog)TBXAS1XP_539887.2
Bos taurus (cattle)TBXAS1NP_001039492.1
Mus musculus (house mouse)Tbxas1NP_035669.3
Rattus norvegicus (Norway rat)Tbxas1NP_036819.1
Gallus gallus (chicken)TBXAS1XP_416334.3
Danio rerio (zebrafish)tbxas1NP_991172.1
GeneCards TBXAS1
UniProt Q16843, Q53F23, B4DJG6, P24557, Q96CN2
MIM 274180
Ensembl ENSG00000059377
HGNC 11609
HPRD 02035

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
thromboxane-A synthase
Names
thromboxane-A synthase
TXA synthase
cytochrome P450 5A1
platelet, cytochrome P450, subfamily V
cytochrome P450, family 5, subfamily A, polypeptide 1
thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
NP_001052.2
NP_001124438.1
NP_001159725.1
NP_001159726.1
NP_112246.2

Interactant

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