TBXAS1 thromboxane A synthase 1 (platelet) [Homo sapiens (human)]

Gene Symbol	TBXAS1
Entrez Gene ID	6916
Full Name	thromboxane A synthase 1 (platelet)
Synonyms	CYP5, CYP5A1, FLJ52771, GHOSAL, THAS, TS, TXAS, TXS
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:7 Map Location:7q34-q35
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Disorder	MIM: 274180 Thromboxane synthase deficiency (2); Ghosal syndrome, 231095 (3)

mRNA	NM_030984, 261278364
Protein	NP_112246, 195972900
Product	thromboxane-A synthase isoform 2
RefSeq Status	REVIEWED
mRNA	NM_001061, 261278363
Protein	NP_001052, 195972898
Product	thromboxane-A synthase isoform 1
RefSeq Status	REVIEWED
mRNA	NM_001130966, 261278366
Protein	NP_001124438, 195972896
Product	thromboxane-A synthase isoform 1
RefSeq Status	REVIEWED
mRNA	NM_001166253, 261278369
Protein	NP_001159725, 261278370
Product	thromboxane-A synthase isoform 3
RefSeq Status	REVIEWED
mRNA	NM_001166254, 261278371
Protein	NP_001159726, 261278372
Product	thromboxane-A synthase isoform 4
RefSeq Status	REVIEWED

KEGG

hsa00590	Arachidonic acid metabolism
hsa01100	Metabolic pathways

WikiPathways

WP98	Prostaglandin Synthesis and Regulation
WP167	Eicosanoid Synthesis

Reactome

REACT_15369	Prostanoid metabolism
REACT_13645	Eicosanoids
REACT_13433	Biological oxidations
REACT_13567	Cytochrome P450 - arranged by substrate type
REACT_13705	Phase 1 - Functionalization of compounds
REACT_22258	Metabolism of lipids and lipoproteins

Homo sapiens (human)	TBXAS1	NP_001052.2
Pan troglodytes (chimpanzee)	TBXAS1	XP_001152761.1
Canis lupus familiaris (dog)	TBXAS1	XP_539887.2
Bos taurus (cattle)	TBXAS1	NP_001039492.1
Mus musculus (house mouse)	Tbxas1	NP_035669.3
Rattus norvegicus (Norway rat)	Tbxas1	NP_036819.1
Gallus gallus (chicken)	TBXAS1	XP_416334.2
Danio rerio (zebrafish)	LOC100331448	XP_002665365.1
Danio rerio (zebrafish)	tbxas1	NP_991172.1

Process

ID	Name	Evidence
GO:0001516	prostaglandin biosynthetic process	IEA
GO:0006633	fatty acid biosynthetic process	IEA
GO:0006692	prostanoid metabolic process	TAS
GO:0006805	xenobiotic metabolic process	TAS
GO:0030644	cellular chloride ion homeostasis	IEA
GO:0042446	hormone biosynthetic process	TAS
GO:0045907	positive regulation of vasoconstriction	IEA

Component

ID	Name	Evidence
GO:0005783	endoplasmic reticulum	IEA
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0005792	microsome	IEA
GO:0016020	membrane	IEA
GO:0016021	integral to membrane	IEA

Function

ID	Name	Evidence
GO:0004497	monooxygenase activity	IEA
GO:0004796	thromboxane-A synthase activity	TAS
GO:0009055	electron carrier activity	IEA
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA
GO:0016853	isomerase activity	IEA
GO:0020037	heme binding	IEA
GO:0046872	metal ion binding	IEA

RefSeq Accession	Definition	Sequence	Price	Select
NM_030984	Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 2, mRNA.	Full Length	$556.51
NM_030984		ORF Sequence	$401.07
NM_001061	Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mRNA.	Full Length	$603.78
NM_001061		ORF Sequence	$465.45
NM_001130966	Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 3, mRNA.	Full Length	$691.65
NM_001130966		ORF Sequence	$465.45
NM_001166253	Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA.	Full Length	$643.80
NM_001166253		ORF Sequence	$505.47
NM_001166254	Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 5, mRNA.	Full Length	$618.28
NM_001166254		ORF Sequence	$406.29