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TBXAS1 thromboxane A synthase 1 (platelet) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001061 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001130966 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_001166253 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001166254 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $509.00 $460.00 12
NM_030984 Homo sapiens thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol TBXAS1
Entrez Gene ID 6916
Full Name thromboxane A synthase 1 (platelet)
Synonyms BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS
General protein information
Preferred Names
thromboxane-A synthase
Names
thromboxane-A synthase
TXA synthase
cytochrome P450 5A1
platelet, cytochrome P450, subfamily V
cytochrome P450, family 5, subfamily A, polypeptide 1
thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)
NP_001052.2
NP_001124438.1
NP_001159725.1
NP_001159726.1
NP_112246.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q34-q35

Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Disorder

MIM: 274180

Thromboxane synthase deficiency (2); Ghosal syndrome, 231095 (3)

mRNA Protein Product Sequence Price Select
NM_001061, 261278363 NP_001052, 195972898 thromboxane-A synthase isoform 1 ORF Sequence $360.00
NM_001130966, 261278366 NP_001124438, 195972896 thromboxane-A synthase isoform 1 ORF Sequence $360.00
NM_001166253, 261278369 NP_001159725, 261278370 thromboxane-A synthase isoform 3 ORF Sequence $700.00
NM_001166254, 261278371 NP_001159726, 261278372 thromboxane-A synthase isoform 4 ORF Sequence $360.00
NM_030984, 261278364 NP_112246, 195972900 thromboxane-A synthase isoform 2 ORF Sequence $550.00
KEGG
hsa00590Arachidonic acid metabolism
hsa04611Platelet activation
WikiPathways
WP98Prostaglandin Synthesis and Regulation
WP167Eicosanoid Synthesis
BIOCYC
HUMAN_PWY66-374prostanoid biosynthesis
META_PWY66-374C20 prostanoid biosynthesis
Reactome
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_13705Phase 1 - Functionalization of compounds
REACT_13645Eicosanoids
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_147851Arachidonic acid metabolism
REACT_150149Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Homo sapiens (human)TBXAS1NP_001052.2
Canis lupus familiaris (dog)TBXAS1XP_539887.2
Bos taurus (cattle)TBXAS1NP_001039492.1
Mus musculus (house mouse)Tbxas1NP_035669.3
Rattus norvegicus (Norway rat)Tbxas1NP_036819.1
Gallus gallus (chicken)TBXAS1XP_416334.4
Danio rerio (zebrafish)tbxas1NP_991172.1
Drosophila melanogaster (fruit fly)Cyp6a20NP_611002.3
Drosophila melanogaster (fruit fly)Cyp6a2NP_523628.1
Drosophila melanogaster (fruit fly)Cyp6a18NP_651563.1
Drosophila melanogaster (fruit fly)Cyp6a8NP_523749.2
Drosophila melanogaster (fruit fly)Cyp6a21NP_611003.2
Drosophila melanogaster (fruit fly)Cyp6a9NP_523748.2
Drosophila melanogaster (fruit fly)Cyp6a19NP_611001.2
Drosophila melanogaster (fruit fly)Cyp6a23NP_611000.2
Drosophila melanogaster (fruit fly)Cyp6a17NP_652018.1
Drosophila melanogaster (fruit fly)Cyp6a22NP_652075.1
Arabidopsis thaliana (thale cress)CYP711A1NP_565617.2
Xenopus (Silurana) tropicalis (western clawed frog)tbxas1NP_001164997.1
Process
IDNameEvidence
GO:0006690icosanoid metabolic processTAS
GO:0006805xenobiotic metabolic processTAS
GO:0019369arachidonic acid metabolic processTAS
GO:0019371cyclooxygenase pathwayTAS
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005789endoplasmic reticulum membraneTAS
GO:0016021integral component of membraneIEA
Function
IDNameEvidence
GO:0004497monooxygenase activityIEA
GO:0004796thromboxane-A synthase activityIEA
GO:0005506iron ion bindingIEA
GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenIEA
GO:0020037heme bindingIEA
GeneCards TBXAS1
UniProt Q53F23, P24557
Vega OTTHUMG00000157302
MIM 274180
Ensembl ENSG00000059377
HGNC 11609
HPRD 02035

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TBXAS1 gene?

The TBXAS1 gene provides instructions for making an enzyme called thromboxane A synthase 1. This enzyme acts as part of a chemical pathway called the arachidonic acid cascade. Through this multistep pathway, a molecule called arachidonic acid is processed to produce several molecules with diverse functions in the body. As part of this pathway, thromboxane A synthase 1 converts a molecule called prostaglandin H2 into another molecule called thromboxane A2. Thromboxane A2 is involved in normal blood clotting (hemostasis), playing critical roles in the narrowing of blood vessels (vasoconstriction) to slow blood flow and the clumping (aggregation) of blood cell fragments called platelets at the site of an injury.

Studies suggest that the activity of thromboxane A synthase 1 may also be important for bone remodeling, which is a normal process in which old bone is removed and new bone is created to replace it, and for the production of red blood cells in bone marrow.

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