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TCF4 transcription factor 4 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001083962 Homo sapiens transcription factor 4 (TCF4), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001243226 Homo sapiens transcription factor 4 (TCF4), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001243227 Homo sapiens transcription factor 4 (TCF4), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001243228 Homo sapiens transcription factor 4 (TCF4), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001243230 Homo sapiens transcription factor 4 (TCF4), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001243231 Homo sapiens transcription factor 4 (TCF4), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001243232 Homo sapiens transcription factor 4 (TCF4), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001243233 Homo sapiens transcription factor 4 (TCF4), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001243234 Homo sapiens transcription factor 4 (TCF4), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001243235 Homo sapiens transcription factor 4 (TCF4), transcript variant 11, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_001243236 Homo sapiens transcription factor 4 (TCF4), transcript variant 12, mRNA. GenEZ ORF Cloning On-demand $699.00 18
NM_003199 Homo sapiens transcription factor 4 (TCF4), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266739 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005266741 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266743 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266744 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266745 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266746 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266747 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266749 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X12, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266750 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X13, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005266752 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X15, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005266754 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X17, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005266755 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X18, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005266761 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X24, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006722529 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X25, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722530 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X26, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722531 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X27, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722532 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X28, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722533 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X29, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006722534 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X30, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006722535 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X31, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006722536 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X32, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006722537 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X33, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006722538 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X34, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006722539 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X35, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_006722540 PREDICTED: Homo sapiens transcription factor 4 (TCF4), transcript variant X36, mRNA. GenEZ ORF Cloning On-demand $699.00 18

*Business Day

Related Services

Gene Symbol TCF4
Entrez Gene ID 6925
Full Name transcription factor 4
Synonyms E2-2, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19
General protein information
Preferred Names
transcription factor 4
Names
transcription factor 4
SL3-3 enhancer factor 2
transcription factor 4, isoform D
transcription factor 4, isoform E
transcription factor 4, isoform R
immunoglobulin transcription factor 2
class B basic helix-loop-helix protein 19
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q21.1

Summary This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011].
Disorder

MIM: 602272

Pitt-Hopkins syndrome, 610954 (3)

mRNA Protein Product Sequence Price Select
NM_001083962, 145312266 NP_001077431, 145312267 transcription factor 4 isoform a ORF Sequence $700.00
NM_001243226, 597709767 NP_001230155, 597709768 transcription factor 4 isoform c ORF Sequence $750.00
NM_001243227, 342672060 NP_001230156, 342672061 transcription factor 4 isoform d ORF Sequence $700.00
NM_001243228, 342672062 NP_001230157, 342672063 transcription factor 4 isoform e ORF Sequence $700.00
NM_001243230, 342672064 NP_001230159, 342672065 transcription factor 4 isoform f ORF Sequence $700.00
NM_001243231, 342672066 NP_001230160, 342672067 transcription factor 4 isoform g ORF Sequence $700.00
NM_001243232, 342672068 NP_001230161, 342672069 transcription factor 4 isoform h ORF Sequence $700.00
NM_001243233, 342672070 NP_001230162, 342672071 transcription factor 4 isoform i ORF Sequence $550.00
NM_001243234, 342672072 NP_001230163, 342672073 transcription factor 4 isoform j ORF Sequence $550.00
NM_001243235, 342672074 NP_001230164, 342672075 transcription factor 4 isoform k ORF Sequence $550.00
NM_001243236, 342672076 NP_001230165, 342672077 transcription factor 4 isoform l ORF Sequence $550.00
NM_003199, 145386535 NP_003190, 4507399 transcription factor 4 isoform b ORF Sequence $700.00
XM_005266739, 578832653 XP_005266796, 530414289 transcription factor 4 isoform X2 ORF Sequence $700.00
XM_005266741, 578832672 XP_005266798, 530414293 transcription factor 4 isoform X4 ORF Sequence $700.00
XM_005266743, 578832673 XP_005266800, 530414297 transcription factor 4 isoform X6 ORF Sequence $700.00
XM_005266744, 578832674 XP_005266801, 530414299 transcription factor 4 isoform X7 ORF Sequence $700.00
XM_005266745, 578832677 XP_005266802, 530414301 transcription factor 4 isoform X8 ORF Sequence $700.00
XM_005266746, 578832678 XP_005266803, 530414303 transcription factor 4 isoform X9 ORF Sequence $700.00
XM_005266747, 578832679 XP_005266804, 530414305 transcription factor 4 isoform X10 ORF Sequence $700.00
XM_005266749, 578832680 XP_005266806, 530414309 transcription factor 4 isoform X12 ORF Sequence $700.00
XM_005266750, 578832681 XP_005266807, 530414311 transcription factor 4 isoform X13 ORF Sequence $700.00
XM_005266752, 578832682 XP_005266809, 530414315 transcription factor 4 isoform X15 ORF Sequence $550.00
XM_005266754, 578832683 XP_005266811, 530414319 transcription factor 4 isoform X17 ORF Sequence $550.00
XM_005266755, 578832684 XP_005266812, 530414321 transcription factor 4 isoform X18 ORF Sequence $550.00
XM_005266761, 578832689 XP_005266818, 530414333 transcription factor 4 isoform X24 ORF Sequence $550.00
XM_006722529, 578832654 XP_006722592, 578832655 transcription factor 4 isoform X25 ORF Sequence $700.00
XM_006722530, 578832656 XP_006722593, 578832657 transcription factor 4 isoform X26 ORF Sequence $700.00
XM_006722531, 578832658 XP_006722594, 578832659 transcription factor 4 isoform X27 ORF Sequence $700.00
XM_006722532, 578832660 XP_006722595, 578832661 transcription factor 4 isoform X28 ORF Sequence $700.00
XM_006722533, 578832662 XP_006722596, 578832663 transcription factor 4 isoform X29 ORF Sequence $700.00
XM_006722534, 578832664 XP_006722597, 578832665 transcription factor 4 isoform X30 ORF Sequence $700.00
XM_006722535, 578832666 XP_006722598, 578832667 transcription factor 4 isoform X31 ORF Sequence $700.00
XM_006722536, 578832668 XP_006722599, 578832669 transcription factor 4 isoform X32 ORF Sequence $700.00
XM_006722537, 578832670 XP_006722600, 578832671 transcription factor 4 isoform X33 ORF Sequence $700.00
XM_006722538, 578832675 XP_006722601, 578832676 transcription factor 4 isoform X34 ORF Sequence $700.00
XM_006722539, 578832685 XP_006722602, 578832686 transcription factor 4 isoform X35 ORF Sequence $550.00
XM_006722540, 578832687 XP_006722603, 578832688 transcription factor 4 isoform X36 ORF Sequence $550.00
WikiPathways
WP363Wnt Signaling Pathway NetPath
WP2064Neural Crest Differentiation
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
ar_pathwayCoregulation of Androgen receptor activity
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Reactome
REACT_21303Myogenesis
REACT_21402CDO in myogenesis
REACT_111045Developmental Biology
Homo sapiens (human)TCF4NP_003190.1
Macaca mulatta (Rhesus monkey)TCF4XP_001084466.2
Canis lupus familiaris (dog)TCF4NP_001003268.1
Bos taurus (cattle)TCF4NP_001029793.1
Mus musculus (house mouse)Tcf4NP_038713.1
Rattus norvegicus (Norway rat)Tcf4NP_445821.1
Xenopus (Silurana) tropicalis (western clawed frog)tcf4NP_001096226.2
Process
IDNameEvidence
GO:0006352DNA-templated transcription, initiationISS
GO:0006367transcription initiation from RNA polymerase II promoterISS
GO:0045666positive regulation of neuron differentiationISS
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0065004protein-DNA complex assemblyISS
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005667transcription factor complexISS
Function
IDNameEvidence
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingISS
GO:0001011sequence-specific DNA binding RNA polymerase recruiting transcription factor activityISS
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionISS
GO:0001087TFIIB-class binding transcription factor activityISS
GO:0001093TFIIB-class transcription factor bindingISS
GO:0003677DNA bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0005515protein bindingIPI
GO:0008022protein C-terminus bindingIPI
GO:0046982protein heterodimerization activityISS
GO:0046982protein heterodimerization activityNAS
GO:0070888E-box bindingISS
GeneCards TCF4
UniProt P15884, H3BTP3, B3KVA4
Vega OTTHUMG00000132713
MIM 602272
Ensembl ENSG00000196628
HGNC 11634
HPRD 03780

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TCF4 gene?

The TCF4 gene provides instructions for making a gene that attaches (binds) to specific regions of DNA and helps control the activity of many other genes. On the basis of this action, the TCF4 protein is known as a transcription factor. The TCF4 protein is part of a group of proteins known as E-proteins. E-proteins each bind with another identical or similar protein and then bind to a specific sequence of DNA known as an E-box. E-proteins are involved in many aspects of development.

The TCF4 protein is found in the brain, muscles, lungs, and heart. This protein also appears to be active (expressed) in various tissues before birth. The TCF4 protein plays a role in the maturation of cells to carry out specific functions (cell differentiation) and the self-destruction of cells (apoptosis).

Interactant

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