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Blast Method:


TECTA tectorin alpha [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005422 Homo sapiens tectorin alpha (TECTA), mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_005271653 PREDICTED: Homo sapiens tectorin alpha (TECTA), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $3749.00 35

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Gene Symbol TECTA
Entrez Gene ID 7007
Full Name tectorin alpha
Synonyms DFNA12, DFNA8, DFNB21
General protein information
Preferred Names
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008].

MIM: 602574

Deafness, autosomal dominant 8/12, 601543 (3); Deafness, autosomal

mRNA Protein Product Sequence Price Select
NM_005422, 134268639 NP_005413, 134268640 alpha-tectorin precursor ORF Sequence $3500.00
XM_005271653, 530398337 XP_005271710, 530398338 alpha-tectorin isoform X1 ORF Sequence $3500.00
Homo sapiens (human)TECTANP_005413.2
Pan troglodytes (chimpanzee)TECTAXP_508823.2
Canis lupus familiaris (dog)TECTAXP_546475.2
Bos taurus (cattle)TECTAXP_003586997.1
Mus musculus (house mouse)TectaNP_033373.2
Rattus norvegicus (Norway rat)TectaNP_001100284.1
Gallus gallus (chicken)TECTAXP_004948075.1
Danio rerio (zebrafish)LOC561355XP_689855.5
Xenopus (Silurana) tropicalis (western clawed frog)LOC100490936XP_002935069.2
GO:0007160cell-matrix adhesionIEA
GO:0007605sensory perception of soundIEA
GO:0005578proteinaceous extracellular matrixIEA
GO:0005886plasma membraneIEA
GO:0031225anchored component of membraneIEA
GO:0070062extracellular vesicular exosomeIDA
GeneCards TECTA
UniProt O75443
Vega OTTHUMG00000149908
MIM 602574
Ensembl ENSG00000109927
HGNC 11720
HPRD 03985

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TECTA gene?

The TECTA gene provides instructions for making a protein called alpha-tectorin. This protein is found in the inner ear, as part of a structure called the tectorial membrane. The tectorial membrane helps to convert sound waves to nerve impulses, a critical process for normal hearing.

Alpha-tectorin interacts with other proteins to form the tectorial membrane. Two regions of the alpha-tectorin protein, called the vWFD domain and the zona pellucida domain, are important for protein interactions and assembly of the tectorial membrane.


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