• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


TERT telomerase reverse transcriptase [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001193376 Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 2, mRNA. ORF Sequence $1123.50
Peptide Services
Antibody Services
Protein Services
NM_198253 Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 1, mRNA. ORF Sequence $1189.65
Peptide Services
Antibody Services
Protein Services


Gene Symbol TERT
Entrez Gene ID 7015
Full Name telomerase reverse transcriptase
Synonyms EST2, TCS1, TP2, TRT, hEST2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5p15.33

Summary Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].
Disorder

MIM: 187270

{Aplastic anemia, susceptibility to}, 609135 (3); {Pulmonary

mRNA Protein Product Sequence Price Select
NM_001193376, 301129199 NP_001180305, 301129200 telomerase reverse transcriptase isoform 2 Full Length $1340.15
ORF Sequence $1123.50
NM_198253, 109633030 NP_937983, 109633031 telomerase reverse transcriptase isoform 1 Full Length $1406.30
ORF Sequence $1189.65
KEGG
hsa05166HTLV-I infection
WikiPathways
WP53Id Signaling Pathway
WP49IL-2 Signaling Pathway
Pathway Interaction Database
il2_pi3kpathwayIL2 signaling events mediated by PI3K
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
hif1_tfpathwayHIF-1-alpha transcription factor network
myc_activpathwayValidated targets of C-MYC transcriptional activation
telomerasepathwayRegulation of Telomerase
Reactome
REACT_22172Chromosome Maintenance
REACT_115566Cell Cycle
REACT_8030Extension of Telomeres
REACT_7970Telomere Maintenance
REACT_7974Telomere Extension By Telomerase
Homo sapiens (human)TERTNP_937983.2
Canis lupus familiaris (dog)TERTNP_001026800.1
Bos taurus (cattle)TERTNP_001039707.1
Mus musculus (house mouse)TertNP_033380.1
Rattus norvegicus (Norway rat)TertNP_445875.1
Gallus gallus (chicken)TERTNP_001026178.1
Danio rerio (zebrafish)tertNP_001077335.1
Arabidopsis thaliana (thale cress)TERTNP_197187.1
GeneCards TERT
PDB 2BCK
UniProt O14746
MIM 187270
Ensembl ENSG00000164362
HGNC 11730
HPRD 01754

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
telomerase reverse transcriptase
Names
telomerase reverse transcriptase
telomerase catalytic subunit
telomerase-associated protein 2
NP_001180305.1
NP_937983.2

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

Secured Online Quotation
Email: gene@genscript.com
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262 1-732-885-5878