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TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu16217 NM_001032280 Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16263 NM_003220 Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu19280 NM_001042425 Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu40448 XM_006715175 PREDICTED: Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu16217C NM_001032280 Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00
OHu16263C NM_003220 Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu19280C NM_001042425 Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 3, mRNA. Customized vector On-demand 7-9 $269.00
OHu40448C XM_006715175 PREDICTED: Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant X1, mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol TFAP2A
Entrez Gene ID 7020
Full Name transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Synonyms AP-2, AP-2alpha, AP2TF, BOFS, TFAP2
General protein information
Preferred Names
transcription factor AP-2-alpha
Names
transcription factor AP-2-alpha
AP2-alpha
activator protein 2
AP-2 transcription factor
activating enhancer-binding protein 2-alpha
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p24

Summary The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009].
Disorder

MIM: 107580

Branchiooculofacial syndrome, 113620 (3)

mRNA Protein Product Sequence Price Select
NM_001032280, 109389356 NP_001027451, 73760407 transcription factor AP-2-alpha isoform b ORF Sequence $550.00
NM_001042425, 109389357 NP_001035890, 109389358 transcription factor AP-2-alpha isoform c ORF Sequence $550.00
NM_003220, 109389359 NP_003211, 4507441 transcription factor AP-2-alpha isoform a ORF Sequence $550.00
XM_006715175, 578811884 XP_006715238, 578811885 transcription factor AP-2-alpha isoform X1 ORF Sequence $550.00
WikiPathways
WP363Wnt Signaling Pathway NetPath
WP2064Neural Crest Differentiation
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
caspase_pathwayCaspase cascade in apoptosis
Homo sapiens (human)TFAP2ANP_003211.1
Pan troglodytes (chimpanzee)TFAP2AXP_001166719.1
Macaca mulatta (Rhesus monkey)TFAP2AXP_001089006.2
Canis lupus familiaris (dog)LOC488213XP_848968.1
Bos taurus (cattle)TFAP2ANP_001073697.1
Mus musculus (house mouse)Tfap2aNP_035677.2
Rattus norvegicus (Norway rat)Tfap2aNP_001100815.1
Gallus gallus (chicken)TFAP2ANP_990425.1
Danio rerio (zebrafish)tfap2aNP_789829.1
Drosophila melanogaster (fruit fly)AP-2NP_001262179.1
Xenopus (Silurana) tropicalis (western clawed frog)tfap2aNP_001032335.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001822kidney developmentIMP
GO:0003151outflow tract morphogenesisIEA
GO:0003334keratinocyte developmentIEA
GO:0003404optic vesicle morphogenesisISS
GO:0003409optic cup structural organizationISS
GO:0006366transcription from RNA polymerase II promoterIDA
GO:0007605sensory perception of soundIMP
GO:0008285negative regulation of cell proliferationIDA
GO:0009880embryonic pattern specificationIEA
GO:0010172embryonic body morphogenesisIEA
GO:0010628positive regulation of gene expressionISS
GO:0010842retina layer formationIEP
GO:0010944negative regulation of transcription by competitive promoter bindingIDA
GO:0010944negative regulation of transcription by competitive promoter bindingIMP
GO:0014032neural crest cell developmentIEA
GO:0021506anterior neuropore closureIEA
GO:0021559trigeminal nerve developmentISS
GO:0021623oculomotor nerve formationISS
GO:0021884forebrain neuron developmentIEA
GO:0030335positive regulation of cell migrationIEA
GO:0030501positive regulation of bone mineralizationIDA
GO:0035115embryonic forelimb morphogenesisISS
GO:0042059negative regulation of epidermal growth factor receptor signaling pathwayIEA
GO:0042472inner ear morphogenesisIMP
GO:0043066negative regulation of apoptotic processIDA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0043525positive regulation of neuron apoptotic processIDA
GO:0045595regulation of cell differentiationIDA
GO:0045664regulation of neuron differentiationIEA
GO:0045892negative regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045893positive regulation of transcription, DNA-templatedISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0048485sympathetic nervous system developmentIEA
GO:0048701embryonic cranial skeleton morphogenesisISS
GO:0048730epidermis morphogenesisIEA
GO:0060021palate developmentIMP
GO:0060235lens induction in camera-type eyeIEA
GO:0060325face morphogenesisIEA
GO:0060349bone morphogenesisISS
GO:0061029eyelid development in camera-type eyeISS
GO:0061303cornea development in camera-type eyeIEA
GO:0070172positive regulation of tooth mineralizationIDA
GO:0071281cellular response to iron ionIDA
GO:0071711basement membrane organizationIEA
GO:0072210metanephric nephron developmentIEA
GO:2000378negative regulation of reactive oxygen species metabolic processIDA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005634nucleusIMP
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005794Golgi apparatusIDA
GO:0005813centrosomeIDA
GO:0043231intracellular membrane-bounded organelleIDA
Function
IDNameEvidence
GO:0000976transcription regulatory region sequence-specific DNA bindingIDA
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDA
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIDA
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA bindingIEA
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activityIDA
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityIDA
GO:0000987core promoter proximal region sequence-specific DNA bindingIDA
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDA
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDA
GO:0001105RNA polymerase II transcription coactivator activityIEA
GO:0001106RNA polymerase II transcription corepressor activityIEA
GO:0003682chromatin bindingISS
GO:0003713transcription coactivator activityIDA
GO:0005515protein bindingIPI
GO:0042803protein homodimerization activityTAS
GO:0043565sequence-specific DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingIDA
GO:0046983protein dimerization activityIDA
GeneCards TFAP2A
UniProt P05549
Vega OTTHUMG00000014235
MIM 107580
Ensembl ENSG00000137203
HGNC 11742
HPRD 00128

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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