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Sequence in raw or FASTA format:


Blast Method:


TG thyroglobulin [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_003235 Homo sapiens thyroglobulin (TG), mRNA. GenEZ ORF Cloning In-stock $2448.00 $2399.00 24
XM_005251038 PREDICTED: Homo sapiens thyroglobulin (TG), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005251040 PREDICTED: Homo sapiens thyroglobulin (TG), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_005251042 PREDICTED: Homo sapiens thyroglobulin (TG), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_005251043 PREDICTED: Homo sapiens thyroglobulin (TG), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $3749.00 35
XM_006716622 PREDICTED: Homo sapiens thyroglobulin (TG), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006716623 PREDICTED: Homo sapiens thyroglobulin (TG), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $3749.00 35

*Business Day

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Gene Symbol TG
Entrez Gene ID 7038
Full Name thyroglobulin
Synonyms AITD3, TGN
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009].

MIM: 188450

Thyroid dyshormonogenesis 3, 274700 (3); {Autoimmune thyroid disease,

mRNA Protein Product Sequence Price Select
NM_003235, 55770861 NP_003226, 55770862 thyroglobulin precursor ORF Sequence $2199.00
XM_005251038, 578816125 XP_005251095, 530389271 thyroglobulin isoform X4 ORF Sequence $4500.00
XM_005251040, 578816126 XP_005251097, 530389275 thyroglobulin isoform X6 ORF Sequence $3500.00
XM_005251042, 578816127 XP_005251099, 530389279 thyroglobulin isoform X8 ORF Sequence $3500.00
XM_005251043, 578816130 XP_005251100, 530389281 thyroglobulin isoform X9 ORF Sequence $3500.00
XM_006716622, 578816123 XP_006716685, 578816124 thyroglobulin isoform X10 ORF Sequence $4500.00
XM_006716623, 578816128 XP_006716686, 578816129 thyroglobulin isoform X11 ORF Sequence $3500.00
hsa05320Autoimmune thyroid disease
hsa04918Thyroid hormone synthesis
WP1981Thyroxine (Thyroid Hormone) Production
Homo sapiens (human)TGNP_003226.4
Pan troglodytes (chimpanzee)TGXP_003311969.1
Macaca mulatta (Rhesus monkey)TGXP_001090053.2
Canis lupus familiaris (dog)TGNP_001041569.1
Bos taurus (cattle)TGNP_776308.1
Mus musculus (house mouse)TgNP_033401.2
Rattus norvegicus (Norway rat)TgNP_112250.2
Gallus gallus (chicken)TGXP_003640916.2
Danio rerio (zebrafish)tgXP_694292.5
Xenopus (Silurana) tropicalis (western clawed frog)tgXP_002939561.2
GO:0006590thyroid hormone generationIBA
GO:0007165signal transductionNAS
GO:0007416synapse assemblyIRD
GO:0015705iodide transportIEA
GO:0030878thyroid gland developmentIEP
GO:0031641regulation of myelinationIEA
GO:0042446hormone biosynthetic processIEA
GO:0005576extracellular regionNAS
GO:0005615extracellular spaceIBA
GO:0005887integral component of plasma membraneIRD
GO:0009986cell surfaceIRD
GO:0004872receptor activityIRD
GO:0005179hormone activityIEA
GO:0042043neurexin family protein bindingIRD
GeneCards TG
UniProt P01266
Vega OTTHUMG00000164649
MIM 188450
Ensembl ENSG00000042832
HGNC 11764
HPRD 01782

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TG gene?

The TG gene provides instructions for making a protein called thyroglobulin, one of the largest proteins in the body. This protein is found only in the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroglobulin combines with iodine and is modified and broken down to release small molecules known as thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). Thyroglobulin also serves as a protein storehouse for iodine and inactive thyroid hormone until these substances are needed.


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