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TG thyroglobulin [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_003235 Homo sapiens thyroglobulin (TG), mRNA. ORF Sequence Quote
Peptide Services
Antibody Services
Protein Services


Gene Symbol TG
Entrez Gene ID 7038
Full Name thyroglobulin
Synonyms AITD3, TGN
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q24

Summary Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009].
Disorder

MIM: 188450

Thyroid dyshormonogenesis 3, 274700 (3); {Autoimmune thyroid disease,

mRNA Protein Product Sequence Price Select
NM_003235, 55770861 NP_003226, 55770862 thyroglobulin precursor Full Length $0.00
ORF Sequence $0.00
KEGG
hsa05320Autoimmune thyroid disease
Homo sapiens (human)TGNP_003226.4
Pan troglodytes (chimpanzee)TGXP_003311969.1
Canis lupus familiaris (dog)TGNP_001041569.1
Bos taurus (cattle)TGNP_776308.1
Mus musculus (house mouse)TgNP_033401.2
Rattus norvegicus (Norway rat)TgNP_112250.1
Gallus gallus (chicken)TGXP_003640916.1
Danio rerio (zebrafish)tgXP_694292.4
GeneCards TG
UniProt P01266
MIM 188450
Ensembl ENSG00000042832
HGNC 11764
HPRD 01782

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

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