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TGFB1 transforming growth factor, beta 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000660 Homo sapiens transforming growth factor, beta 1 (TGFB1), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol TGFB1
Entrez Gene ID 7040
Full Name transforming growth factor, beta 1
Synonyms CED, DPD1, LAP, TGFB, TGFbeta
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009].

MIM: 190180

Camurati-Engelmann disease, 131300 (3); {Cystic fibrosis lung

mRNA Protein Product Sequence Price Select
NM_000660, 260655621 NP_000651, 63025222 transforming growth factor beta-1 precursor ORF Sequence $400.00
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa04672Intestinal immune network for IgA production
hsa05220Chronic myeloid leukemia
hsa04060Cytokine-cytokine receptor interaction
hsa05142Chagas disease (American trypanosomiasis)
hsa05212Pancreatic cancer
hsa04110Cell cycle
hsa04380Osteoclast differentiation
hsa05414Dilated cardiomyopathy
hsa05210Colorectal cancer
hsa05200Pathways in cancer
hsa04010MAPK signaling pathway
hsa04350TGF-beta signaling pathway
hsa05211Renal cell carcinoma
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05323Rheumatoid arthritis
Pathway Interaction Database
rxr_vdr_pathwayRXR and RAR heterodimerization with other nuclear receptor
alk1pathwayALK1 signaling events
telomerasepathwayRegulation of Telomerase
il12_stat4pathwayIL12 signaling mediated by STAT4
glypican_1pathwayGlypican 1 network
syndecan_2_pathwaySyndecan-2-mediated signaling events
tgfbrpathwayTGF-beta receptor signaling
il27pathwayIL27-mediated signaling events
syndecan_1_pathwaySyndecan-1-mediated signaling events
WP474Endochondral Ossification
WP366TGF-beta Receptor Signaling Pathway
WP382MAPK signaling pathway
WP69TCR Signaling Pathway
WP179Cell cycle
WP2256Integrated Pancreatic Cancer Pathway
WP1544MicroRNAs in cardiomyocyte hypertrophy
WP530Cytokines and Inflammatory Response
WP1559TFs Regulate miRNAs related to cardiac hypertrophy
WP2332Interleukin-11 Signaling Pathway
WP710DNA damage response (only ATM dependent)
WP560TGF Beta Signaling Pathway
WP554ACE Inhibitor Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP615Senescence and Autophagy
REACT_120850TGF-beta receptor signaling activates SMADs
REACT_27161Transcriptional Regulation of White Adipocyte Differentiation
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_111102Signal Transduction
REACT_798Platelet activation, signaling and aggregation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_111045Developmental Biology
REACT_6213Influenza Virus Induced Apoptosis
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_318Platelet degranulation
REACT_6323Host Interactions with Influenza Factors
REACT_6167Influenza Infection
Homo sapiens (human)TGFB1NP_000651.3
Pan troglodytes (chimpanzee)TGFB1XP_512687.2
Canis lupus familiaris (dog)TGFB1NP_001003309.1
Bos taurus (cattle)TGFB1NP_001159540.1
Mus musculus (house mouse)Tgfb1NP_035707.1
Rattus norvegicus (Norway rat)Tgfb1NP_067589.1
Danio rerio (zebrafish)LOC563884XP_692338.2
Danio rerio (zebrafish)tgfb1aNP_878293.1
GeneCards TGFB1
UniProt P01137
MIM 190180
Ensembl ENSG00000105329
HGNC 11766
HPRD 01821

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information


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