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TGFBI transforming growth factor, beta-induced, 68kDa [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000358 Homo sapiens transforming growth factor, beta-induced, 68kDa (TGFBI), mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

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Gene Symbol TGFBI
Entrez Gene ID 7045
Full Name transforming growth factor, beta-induced, 68kDa
Synonyms BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31

Summary This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008].
Disorder

MIM: 601692

Corneal dystrophy, Groenouw type I, 121900 (3); Corneal dystrophy,

mRNA Protein Product Sequence Price Select
NM_000358, 170650698 NP_000349, 4507467 transforming growth factor-beta-induced protein ig-h3 precursor ORF Sequence $700.00
Reactome
REACT_75925Amyloids
REACT_116125Disease
Homo sapiens (human)TGFBINP_000349.1
Pan troglodytes (chimpanzee)TGFBIXP_001169327.1
Macaca mulatta (Rhesus monkey)TGFBIXP_001111447.1
Canis lupus familiaris (dog)TGFBIXP_538640.3
Bos taurus (cattle)TGFBINP_001192331.1
Mus musculus (house mouse)TgfbiNP_033395.1
Rattus norvegicus (Norway rat)TgfbiNP_446254.1
Gallus gallus (chicken)TGFBINP_990367.1
Danio rerio (zebrafish)tgfbiNP_878282.1
Drosophila melanogaster (fruit fly)mfasNP_788650.1
Xenopus (Silurana) tropicalis (western clawed frog)tgfbiNP_001072329.1
Process
IDNameEvidence
GO:0001525angiogenesisIEP
GO:0002062chondrocyte differentiationIEA
GO:0007155cell adhesionIEA
GO:0007162negative regulation of cell adhesionTAS
GO:0007601visual perceptionIEA
GO:0008283cell proliferationTAS
GO:0030198extracellular matrix organizationIEA
GO:0050896response to stimulusIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005604basement membraneIEA
GO:0005615extracellular spaceIDA
GO:0005802trans-Golgi networkIDA
GO:0005886plasma membraneTAS
GO:0031012extracellular matrixIDA
GO:0031012extracellular matrixISS
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005178integrin bindingTAS
GO:0005515protein bindingIPI
GO:0005518collagen bindingIPI
GO:0050840extracellular matrix bindingIEA
GeneCards TGFBI
PDB 1X3B, 2LTB, 2VXP, 2LTC
UniProt Q15582
Vega OTTHUMG00000163213
MIM 601692
Ensembl ENSG00000120708
HGNC 11771
HPRD 03409

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the TGFBI gene?

The TGFBI gene provides instructions for making a protein called transforming growth factor beta-induced (TGFBI). This protein is released (secreted) from cells and becomes part of the extracellular matrix, which is an intricate network that forms in the spaces between cells and provides structural support to tissues. The TGFBI protein is thought to play a role in the attachment of cells to one another (cell adhesion) and cell movement (migration). This protein is found in many tissues in the body, including the the clear, outer covering of the eye (the cornea).

Interactant

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