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TGFBR1 transforming growth factor, beta receptor 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001130916 Homo sapiens transforming growth factor, beta receptor 1 (TGFBR1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_004612 Homo sapiens transforming growth factor, beta receptor 1 (TGFBR1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol TGFBR1
Entrez Gene ID 7046
Full Name transforming growth factor, beta receptor 1
Synonyms AAT5, ACVRLK4, ALK-5, ALK5, LDS1A, LDS2A, SKR4, TGFR-1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].

MIM: 190181

Loeys-Dietz syndrome, type 1A, 609192 (3); Loeys-Dietz syndrome,

mRNA Protein Product Sequence Price Select
NM_001130916, 195963411 NP_001124388, 195963412 TGF-beta receptor type-1 isoform 2 precursor ORF Sequence $550.00
NM_004612, 66346739 NP_004603, 4759226 TGF-beta receptor type-1 isoform 1 precursor ORF Sequence $550.00
hsa05166HTLV-I infection
hsa05212Pancreatic cancer
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
hsa04520Adherens junction
hsa05142Chagas disease (American trypanosomiasis)
hsa04380Osteoclast differentiation
hsa05161Hepatitis B
hsa05210Colorectal cancer
hsa04010MAPK signaling pathway
hsa05220Chronic myeloid leukemia
hsa04350TGF-beta signaling pathway
Pathway Interaction Database
glypican_1pathwayGlypican 1 network
tgfbrpathwayTGF-beta receptor signaling
alk1pathwayALK1 signaling events
WP382MAPK signaling pathway
WP560TGF Beta Signaling Pathway
WP366TGF-beta Receptor Signaling Pathway
WP2256Integrated Pancreatic Cancer Pathway
WP1984Integrated Breast Cancer Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP400p38 MAPK Signaling Pathway
REACT_120726TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
REACT_6844Signaling by TGF-beta Receptor Complex
REACT_120727Downregulation of TGF-beta receptor signaling
REACT_111102Signal Transduction
REACT_120850TGF-beta receptor signaling activates SMADs
Homo sapiens (human)TGFBR1NP_004603.1
Pan troglodytes (chimpanzee)TGFBR1XP_001159299.1
Macaca mulatta (Rhesus monkey)TGFBR1XP_001112621.1
Canis lupus familiaris (dog)TGFBR1XP_538750.3
Bos taurus (cattle)TGFBR1NP_777046.1
Mus musculus (house mouse)Tgfbr1NP_033396.1
Rattus norvegicus (Norway rat)Tgfbr1NP_036907.2
Gallus gallus (chicken)TGFBR1NP_989577.1
Danio rerio (zebrafish)tgfbr1bNP_001108531.1
Drosophila melanogaster (fruit fly)baboNP_477000.1
GeneCards TGFBR1
PDB 2WOU, 1IAS, 2PJY, 1B6C, 1TBI, 3TZM, 3GXL, 2WOT, 3HMM, 2L5S, 3KCF, 2X7O, 3FAA, 1VJY, 1PY5, 3KFD, 1RW8
UniProt Q5T7S2, P36897
MIM 190181
Ensembl ENSG00000106799
HGNC 11772
HPRD 01822

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information


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